WormBase Tree Display for Gene: WBGene00010776
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| WBGene00010776 | SMap | S_parent | Sequence | K11E4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | pix-1 | Person_evidence | WBPerson3660 | |||||
| WBPerson855 | |||||||||
| Sequence_name | K11E4.4 | ||||||||
| Molecular_name | K11E4.4a | ||||||||
| K11E4.4a.1 | |||||||||
| CE42239 | |||||||||
| K11E4.4b | |||||||||
| CE45486 | |||||||||
| K11E4.4b.1 | |||||||||
| Other_name | tag-207 | ||||||||
| CELE_K11E4.4 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | pix-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 15 Dec 2006 13:58:33 | WBPerson1847 | Name_change | CGC_name | pix-1 | ||||
| Other_name | tag-207 | ||||||||
| 3 | 22 Feb 2008 08:59:15 | WBPerson1983 | Event | Split_into | WBGene00077679 | ||||
| Split_into | WBGene00077679 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pix | ||||||||
| Allele (139) | |||||||||
| Strain | WBStrain00035952 | ||||||||
| WBStrain00036130 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00006496 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00006805 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006887 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009337 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010111 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015704 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | pix-1 is encodes a GTPase activator protein that forms a highly conserved signaling complex with GIT-1 and PAK, and interacts with Rac/CDC42 GTPases; pix-1 is orthologous to mammalian alpha-pix (OMIM: 300267); PIX-1 work together with GIT-1 and PAK-1 independently of RAC/CDC-42 GTPases to control DTC migration during gonad morphogenesis; in epithelial morphogenesis, PIX-1, GIT-1 and PAK-1 together regulate intermediate-filament phosphorylation and CeHD biogenesis; Tension exerted by adjacent muscles or externally exerted mechanical pressure maintains GIT-1 at hemidesmosome and stimulates PAK-1 activity through PIX-1 and Rac; expressed in Z1/Z4 at L1 stage. PIX-1 is expressed in CeHDs and migrating DTCs. | Paper_evidence | WBPaper00032371 | |||||
| WBPaper00038193 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 12 Jul 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable guanyl-nucleotide exchange factor activity. Involved in gonad morphogenesis; inductive cell migration; and neuron migration. Located in anchoring junction; cell periphery; and cytoplasm. Expressed in hermaphrodite gonad; hypodermis; and somatic gonad precursor. Human ortholog(s) of this gene implicated in intellectual disability. Is an ortholog of human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:685) | ||||
| Molecular_info | Corresponding_CDS | K11E4.4a | |||||||
| K11E4.4b | |||||||||
| Corresponding_CDS_history | K11E4.4:wp188 | ||||||||
| Corresponding_transcript | K11E4.4a.1 | ||||||||
| K11E4.4b.1 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00007314 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00050605 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8757 | ||||||||
| Expr11073 | |||||||||
| Expr11813 | |||||||||
| Expr15283 | |||||||||
| Expr1014347 | |||||||||
| Expr1034716 | |||||||||
| Expr1154313 | |||||||||
| Expr2014943 | |||||||||
| Expr2033178 | |||||||||
| Drives_construct | WBCnstr00005767 | ||||||||
| WBCnstr00019251 | |||||||||
| WBCnstr00019465 | |||||||||
| WBCnstr00031155 | |||||||||
| Construct_product | WBCnstr00008105 | ||||||||
| WBCnstr00019251 | |||||||||
| WBCnstr00019252 | |||||||||
| WBCnstr00019465 | |||||||||
| WBCnstr00031155 | |||||||||
| Antibody | WBAntibody00002940 | ||||||||
| WBAntibody00002941 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (75) | |||||||||
| Interaction (50) | |||||||||
| Map_info | Map | X | Position | 14.4983 | Error | 0.071335 | |||
| Positive | Positive_clone | K11E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4898 | |||||||
| 4143 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
