WormBase Tree Display for Gene: WBGene00006887
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| WBGene00006887 | SMap | S_parent | Sequence | C35B8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | vav-1 | Person_evidence | WBPerson404 | |||||
| Sequence_name | C35B8.2 | ||||||||
| Molecular_name | C35B8.2a | ||||||||
| C35B8.2a.1 | |||||||||
| CE38040 | |||||||||
| C35B8.2b | |||||||||
| CE39333 | |||||||||
| C35B8.2c | |||||||||
| CE53342 | |||||||||
| C35B8.2b.1 | |||||||||
| C35B8.2c.1 | |||||||||
| Other_name | CELE_C35B8.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | vav-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vav | ||||||||
| Allele (258) | |||||||||
| Strain | WBStrain00003320 | ||||||||
| WBStrain00035617 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00003931 | ||||||||
| 00003932 | |||||||||
| 00080791 | |||||||||
| 00080792 | |||||||||
| 00080793 | |||||||||
| 00080794 | |||||||||
| 00080795 | |||||||||
| 00080796 | |||||||||
| 00080797 | |||||||||
| 00114965 | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00006496 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00006805 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009337 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010111 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010776 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015704 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | vav-1 encodes a Rho/Rac-family guanine nucleotide exchange factor orthologous to the Vav proto-oncogene; VAV-1 is a complex protein with several domains, from N- to C-terminus: a calponin-like actin-binding domain; a RhoGEF/DH domain; a pleckstrin-like domain; a SH2 motif domain; and an SH3 domain; in C. elegans vav-1 is an essential gene and functions to regulate the concentration of intracellular calcium and thus, plays a key role in regulating rhythmic behaviors such as pharyngeal pumping, ovulation, and defecation; in addition, vav-1 has been shown to be a target of the mir-61 miRNA in the secondary vulval precursor cells, where it functions to negatively regulate LIN-12 activity; VAV-1::GFP reporters are expressed in the pharynx, the contractile sheath cells of the gonad, the four posterior-most intestinal cells, and the three rectal epithelial cells; VAV-1::GFP is also seen in the distal gonad, body wall muscle, and in the vulval precursor cells and their descendants. | Paper_evidence | WBPaper00012852 | |||||
| WBPaper00026850 | |||||||||
| WBPaper00026909 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Feb 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of nematode male tail tip morphogenesis; and regulation of vulval development. Predicted to be located in cytoplasm. Expressed in several structures, including gonad; intestinal cell; neurons; pharyngeal cell; and tail hypodermis. Is an ortholog of human VAV1 (vav guanine nucleotide exchange factor 1); VAV2 (vav guanine nucleotide exchange factor 2); and VAV3 (vav guanine nucleotide exchange factor 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C35B8.2a | |||||||
| C35B8.2b | |||||||||
| C35B8.2c | |||||||||
| Corresponding_CDS_history | C35B8.2:wp129 | ||||||||
| C35B8.2:wp138 | |||||||||
| C35B8.2:wp151 | |||||||||
| C35B8.2b:wp271 | |||||||||
| Corresponding_transcript | C35B8.2a.1 | ||||||||
| C35B8.2b.1 | |||||||||
| C35B8.2c.1 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature (16) | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00000019 | ||||||||
| WBCnstr00003791 | |||||||||
| WBCnstr00008160 | |||||||||
| WBCnstr00011643 | |||||||||
| WBCnstr00011704 | |||||||||
| WBCnstr00020222 | |||||||||
| WBCnstr00034113 | |||||||||
| Construct_product | WBCnstr00000018 | ||||||||
| WBCnstr00000019 | |||||||||
| WBCnstr00000020 | |||||||||
| WBCnstr00000027 | |||||||||
| WBCnstr00011643 | |||||||||
| WBCnstr00014782 | |||||||||
| WBCnstr00019921 | |||||||||
| WBCnstr00019932 | |||||||||
| WBCnstr00020222 | |||||||||
| WBCnstr00034113 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (106) | |||||||||
| Interaction (113) | |||||||||
| WBProcess | WBbiopr:00000044 | ||||||||
| WBbiopr:00000053 | |||||||||
| WBbiopr:00000120 | |||||||||
| Map_info | Map | X | Position | 0.858443 | Error | 0.015966 | |||
| Positive | Positive_clone | C35B8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4774 | |||||||
| 4378 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (27) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
