WormBase Tree Display for Gene: WBGene00006768

WBGene00006768 SMap: S_parent: Sequence: ZK637
  Identity: Version: 1
    Name: CGC_name: unc-32 Person_evidence: WBPerson261
      Sequence_name: ZK637.8
      Molecular_name (18)
      Other_name: CELE_ZK637.8 Accession_evidence: NDB BX284603
      Public_name: unc-32
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143023
    Allele (71)
    Possibly_affected_by: WBVar02157789
      WBVar02157790
    Legacy_information: e189 : severe coiler little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c. ES3 ME0 NA1 (rare mutation).
      [Thierry-Mieg]
      See also eIs16, f120, f121, f123
      [C.elegansII] e189 : severe coiler, little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c; Ric. ES3 ME0. OA>5: f123 (lethal, f123/e189 coiler),f121 (lethal, f121/e189 almost WT), ut61, ut111(embryonic lethals, irregular shape). Most alleles lethal. Cloned: probably encodes protein with homology to glutathione reductase (ZK637.10); downstream gene in operon. [Brenner 1974; Nguyen et al. 1995; FF; JC]
    Strain (305)
    RNASeq_FPKM (74)
    GO_annotation (28)
    Contained_in_operon: CEOP3556
    Ortholog: WBGene00055212 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00024808 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00025861 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00026344 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00029076 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00132495 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
      WBGene00192253 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00104585 Pristionchus pacificus From_analysis: OMA
            WormBase-Compara
      WBGene00193147 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00234199 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g5885 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g13116 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP21.g13570 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP21.g9004 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g21865 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP31.g25896 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP38.g20894 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP40.g6783 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00051.g2654 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-32 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g15228 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00078.g3528 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_22287 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_009304 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06666 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06668 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12681 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g5890 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30272100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g8500 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00133130 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00212986 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00245671 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00261644 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00289220 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000005796 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      SGD:S000004658 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0032373 Drosophila melanogaster From_analysis: OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0038613 Drosophila melanogaster From_analysis: OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0028670 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0028671 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0028669 Drosophila melanogaster From_analysis: OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-030131-3027 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2022 Danio rerio From_analysis: OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-050522-215 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060526-4 Danio rerio From_analysis: OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-091113-4 Danio rerio From_analysis: OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-090311-31 Danio rerio From_analysis: OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-141212-282 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:865 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11647 Homo sapiens From_analysis: OrthoFinder
            Panther
            PhylomeDB
      HGNC:18481 Homo sapiens From_analysis: OrthoFinder
            Panther
            PhylomeDB
      HGNC:866 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:103286 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:104855 Mus musculus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      MGI:2153480 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:68405 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:735136 Rattus norvegicus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      RGD:1305055 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00043993 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
      WBGene00006916 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00006915 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006914 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: unc-32 encodes, by alternative splicing, six isoforms of an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); UNC-32 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); one UNC-32 isoform is essential for locomotion and normal synaptic vesicle morphology in motoneurons, is expressed solely in the nervous system, and is specifically mutated by unc-32(e189) or unc-32(f120); other UNC-32 isoforms are essential for embryonic and larval development; UNC-32 is expressed throughout the life cycle, strongly in the nervous system, but also in vulvae, spermathecal-uterine valves, intestine, and pharynx; UNC-32 is required for necrosis, since mutations of unc-32 suppress necrotic neurodegeneration and thapsigargin-induced cell death; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; alternative splicing of the unc-32 pre-mRNA is dependent on ASD-1 and FOX-1, and in neurons, is also dependent on UNC-75, which binds unc-32 intron 7a in vitro. Paper_evidence: WBPaper00004601
            WBPaper00004842
            WBPaper00025183
            WBPaper00028773
            WBPaper00028774
            WBPaper00028775
            WBPaper00042088
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 26 Mar 2013 00:00:00
      Automated_description: Predicted to enable ATPase binding activity. Involved in several processes, including cholinergic synaptic transmission; defense response to Gram-positive bacterium; and positive regulation of neurotransmitter secretion. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in several structures, including alimentary muscle; hermaphrodite gonad; neurons; somatic nervous system; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of human ATP6V0A1 (ATPase H+ transporting V0 subunit a1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070390 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:865)
      DOID:0110942 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11647)
      DOID:14219 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:866)
      DOID:0112171 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18481)
      EFO:MONDO:0015827 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:866)
      DOID:0070134 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18481)
  Molecular_info: Corresponding_CDS: ZK637.8a
      ZK637.8b
      ZK637.8c
      ZK637.8d
      ZK637.8e
      ZK637.8f
    Corresponding_CDS_history: ZK637.8a:wp77
      ZK637.8b:wp77
    Corresponding_transcript: ZK637.8a.1
      ZK637.8b.1
      ZK637.8c.1
      ZK637.8d.1
      ZK637.8e.1
      ZK637.8f.1
    Other_sequence (98)
    Associated_feature (12)
  Experimental_info: RNAi_result (28)
    Expr_pattern: Expr21
      Expr848
      Expr849
      Expr2405
      Expr1026854
      Expr1032841
      Expr1163008
      Expr2017865
      Expr2036001
    Drives_construct: WBCnstr00000434
      WBCnstr00006396
      WBCnstr00010008
      WBCnstr00010009
      WBCnstr00010814
      WBCnstr00013318
      WBCnstr00017554
    Construct_product: WBCnstr00000434
      WBCnstr00006396
      WBCnstr00014414
      WBCnstr00015831
      WBCnstr00017091
      WBCnstr00017553
      WBCnstr00041445
    Microarray_results (39)
    Expression_cluster (124)
    Interaction (84)
  Map_info: Map: III Position: 0
    Well_ordered
    Positive: Inside_rearr: mnDp37
      Positive_clone: A1D10
        A1F1
        T05B2
        ZK637 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: tnDf2
    Mapping_data: 2_point (34)
      Multi_point (263)
      Pos_neg_data: 806
        3726
        8637
        8642
        9451
    Landmark_gene
  Reference (150)
  Method: Gene