WormBase Tree Display for Gene: HGNC:866
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| HGNC:866 | Identity | Name | CGC_name | Atp6v0a4 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name (26) | ||||||
| Public_name | Atp6v0a4 | |||||
| DB_info | Database | HGNC | id | 866 | ||
| AGR | cURI | HGNC:866 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000105929 | ||||
| UniProt | UniProt_AC | Q9HBG4 | ||||
| OMIM | gene | 605239 | ||||
| DO | id | DOID:14219 | ||||
| EFO:MONDO:0015827 | ||||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00006915 | Caenorhabditis elegans | From_analysis | OrthoFinder | ||
| Panther | ||||||
| PhylomeDB | ||||||
| WBGene00006768 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | |||
| Inparanoid | ||||||
| OrthoFinder | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| WBGene00006914 | Caenorhabditis elegans | From_analysis | OrthoFinder | |||
| Panther | ||||||
| PhylomeDB | ||||||
| WBGene00006916 | Caenorhabditis elegans | From_analysis | OrthoFinder | |||
| Panther | ||||||
| PhylomeDB | ||||||
| Structured_description | Automated_description | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq, Jul 2008] | Inferred_automatically | AGR_import |
