WormBase Tree Display for Gene: WBGene00006916
expand all nodes | collapse all nodes | view schema
| WBGene00006916 | SMap | S_parent | Sequence | C26H9A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | vha-7 | |||||||
| Sequence_name | C26H9A.1 | ||||||||
| Molecular_name | C26H9A.1a | ||||||||
| C26H9A.1a.1 | |||||||||
| CE30882 | |||||||||
| C26H9A.1b | |||||||||
| CE43617 | |||||||||
| C26H9A.1c | |||||||||
| CE50146 | |||||||||
| C26H9A.1b.1 | |||||||||
| C26H9A.1c.1 | |||||||||
| Other_name | CELE_C26H9A.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | vha-7 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vha | ||||||||
| Allele (158) | |||||||||
| Legacy_information | [Pujol N] vha-7 is not expressed in embryos and young larvae, expression starts at the L3/L4 larval stage and is seen in early oocytes and in the spermateca in L4 and adult. | ||||||||
| Strain | WBStrain00036672 | ||||||||
| WBStrain00036675 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (58) | |||||||||
| Paralog | WBGene00006768 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006914 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006915 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | vha-7 encodes an ortholog of subunit a of the membrane-bound (V0) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-7 is orthologousto human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutatedin distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated inosteopetrosis); vha-7 is expressed in hypodermis and uterus; VHA-7 isdispensable for viability, since vha-7(RNAi) animals develop to normal,healthy adults; in S. cerevisiae, different V0 a-subunits (Stv1p andVph1p) direct the assembly of V-ATPases to different membranes andorganelles, suggesting that the profusion of such subunits in C. elegans(co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have asimilar function; VHA-7 is predicted to capture protons from V-ATPasetransmembrane rotor components and export the protons across themembrane. | Paper_evidence | WBPaper00004601 | |||||
| WBPaper00004842 | |||||||||
| WBPaper00025183 | |||||||||
| WBPaper00028773 | |||||||||
| WBPaper00028774 | |||||||||
| WBPaper00028775 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 19 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase binding activity. Predicted to be involved in vacuolar acidification. Predicted to be located in plasma membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Expressed in hypodermis; spermatheca; and uterus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070390 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:865) | ||||
| DOID:0110942 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11647) | ||||||
| DOID:14219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:866) | ||||||
| DOID:0112171 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18481) | ||||||
| EFO:MONDO:0015827 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:866) | ||||||
| DOID:0070134 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18481) | ||||||
| Molecular_info | Corresponding_CDS | C26H9A.1a | |||||||
| C26H9A.1b | |||||||||
| C26H9A.1c | |||||||||
| Corresponding_CDS_history | C26H9A.1:wp80 | ||||||||
| C26H9A.1b:wp201 | |||||||||
| Corresponding_transcript | C26H9A.1a.1 | ||||||||
| C26H9A.1b.1 | |||||||||
| C26H9A.1c.1 | |||||||||
| Other_sequence (23) | |||||||||
| Associated_feature | WBsf660824 | ||||||||
| WBsf660825 | |||||||||
| WBsf716582 | |||||||||
| WBsf998185 | |||||||||
| WBsf1018405 | |||||||||
| WBsf1018406 | |||||||||
| WBsf229309 | |||||||||
| WBsf229310 | |||||||||
| WBsf229311 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00070706 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00070604 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001556 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041290 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00069440 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070705 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011229 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr852 | ||||||||
| Expr9594 | |||||||||
| Expr1022051 | |||||||||
| Expr1032933 | |||||||||
| Expr1145330 | |||||||||
| Expr2017993 | |||||||||
| Expr2036129 | |||||||||
| Drives_construct | WBCnstr00014158 | ||||||||
| WBCnstr00017253 | |||||||||
| WBCnstr00039284 | |||||||||
| WBCnstr00042611 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (158) | |||||||||
| Interaction (12) | |||||||||
| Map_info | Map | IV | Position | 6.12684 | Error | 0.001726 | |||
| Positive | Positive_clone | C26H9A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Sequence From: Pujol Nathalie via ACEDB feedback page <pujol@lgpd.univ-mrs.fr> | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
