WormBase Tree Display for Gene: HGNC:11647

HGNC:11647 Identity: Name: CGC_name: Tcirg1 Inferred_automatically: AGR_import
      Other_name (34)
      Public_name: Tcirg1
    DB_info: Database: HGNC id 11647
        AGR cURI HGNC:11647
        EnsEMBL ENSEMBL_geneID ENSG00000110719
        UniProt UniProt_AC Q13488
        OMIM gene 604592
        DO id DOID:0110942
    Species: Homo sapiens
    Status: Live
  Gene_info: Biotype: SO:0001217
    Ortholog: WBGene00006915 Caenorhabditis elegans From_analysis: OrthoFinder
            Panther
            PhylomeDB
      WBGene00006768 Caenorhabditis elegans From_analysis: OrthoFinder
            Panther
            PhylomeDB
      WBGene00006914 Caenorhabditis elegans From_analysis: OrthoFinder
            Panther
            PhylomeDB
      WBGene00006916 Caenorhabditis elegans From_analysis: OrthoFinder
            Panther
            PhylomeDB
    Structured_description: Automated_description: This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017] Inferred_automatically: AGR_import