| WBGene00006760 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | CHROMOSOME_V |
| Identity | Version | 2 |
| | Name | CGC_name | unc-23 | Person_evidence | WBPerson261 |
| | | Sequence_name | H14N18.1 |
| | | Molecular_name (9) |
| | | Other_name | vab-4 |
| | | | bag-2 | Paper_evidence | WBPaper00048629 |
| | | | CELE_H14N18.1 | Accession_evidence | NDB | BX284605 |
| | | Public_name | unc-23 |
| | DB_info | Database | AceView | gene | 5J419 |
| | | | WormQTL | gene | WBGene00006760 |
| | | | WormFlux | gene | WBGene00006760 |
| | | | NDB | locus_tag | CELE_H14N18.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006760|UniProtKB=O61980 |
| | | | | family | PTHR12334 |
| | | | NCBI | gene | 179272 |
| | | | RefSeq | protein | NM_072906.7 |
| | | | | | NM_182342.6 |
| | | | | | NM_001392570.1 |
| | | | TREEFAM | TREEFAM_ID | TF102012 |
| | | | TrEMBL | UniProtAcc | Q5TKA9 |
| | | | | | Q86S24 |
| | | | | | O61980 |
| | | | UniProt_GCRP | UniProtAcc | O61980 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 03 Nov 2015 10:56:26 | WBPerson2970 | Name_change | Other_name | bag-2 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00142919 |
| | Allele (62) |
| | Legacy_information | e25 : `benthead' progressive dystrophy of head musculature so that adult head is bent dorsally or ventrally hence very poor forward movement good reverse movement. Egl. ES3 (adult) ME1. NA8 (e324 : resembles e25; e611 (pka vab-4 : incompletely penetrant allele) etc.). |
| | | See also e25, e462, e478, e611, e621, e988, e1182, e2154 |
| | | [C.elegansII] e25 : "benthead" phenotype, progressive dystrophy of head musculature so that adult head is bent dorsally or ventrally, hence very poor forward movement, good reverse movement; defects in muscle attachment (Mua); Egl. Phenotype partly suppressed by growth in liquid. ES3 (adult) ME1. OA>10: e324 (resembles e25), e611 (pka vab-4, impenetrant allele), e988, e2154 etc. [Waterston et al. 1980; CB; DR; NJ] |
| | Strain | WBStrain00032000 |
| | | WBStrain00033526 |
| | | WBStrain00034712 |
| | | WBStrain00003976 |
| | | WBStrain00003958 |
| | | WBStrain00004081 |
| | | WBStrain00004149 |
| | | WBStrain00004186 |
| | | WBStrain00005873 |
| | | WBStrain00005890 |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Ortholog (36) |
| | Structured_description | Concise_description | unc-23 encodes a protein with similarity to the BAG2 (BCL2 AnthaGene) protein that functions to negatively regulate proteosomal degradation by the E3 ubiquitin ligase and Hsp70 co-chaperone CHIP (Carboxyl-terminus of Hsp70 Interacting Protein); in C. elegans, unc-23 is required for proper attachment of the anterior body wall musculature to the overlying hypodermis. | Paper_evidence | WBPaper00040313 |
| | | | | | WBPaper00000461 |
| | | | | | WBPaper00003943 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 29 Oct 2015 00:00:00 |
| | | Automated_description | Enables ATPase activator activity and heat shock protein binding activity. Acts upstream of with a positive effect on muscle attachment. Located in M band; nucleolus; and striated muscle dense body. Expressed in several structures, including anal depressor muscle; excretory canal; pharynx; touch receptor neurons; and vulva. Is an ortholog of human BAG2 (BAG cochaperone 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | H14N18.1a |
| | | H14N18.1b |
| | | H14N18.1c |
| | Corresponding_transcript | H14N18.1a.1 |
| | | H14N18.1b.1 |
| | | H14N18.1c.1 |
| | Other_sequence (11) |
| | Associated_feature | WBsf647031 |
| | | WBsf647032 |
| | | WBsf661014 |
| | | WBsf661015 |
| | | WBsf661510 |
| | | WBsf981973 |
| | | WBsf232176 |
| | | WBsf232177 |
| | | WBsf232178 |
| Experimental_info | RNAi_result (14) |
| | Expr_pattern | Expr11891 |
| | | Expr12480 |
| | | Expr1012508 |
| | | Expr1032833 |
| | | Expr1153142 |
| | | Expr2017856 |
| | | Expr2035992 |
| | Drives_construct | WBCnstr00019716 |
| | | WBCnstr00019717 |
| | | WBCnstr00034167 |
| | Construct_product | WBCnstr00021438 |
| | | WBCnstr00034167 |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_larva_enriched |
| | | WBPaper00037950:hypodermis_larva_SelectivelyEnriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:nucleus_specific |
| | | WBPaper00051257:Levamisole_upregulated |
| | | WBPaper00051265:F4_hrde-1(tm1200)_downregulated |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055941:nuo-6(qm200)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056039:efa-6(tm3124)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056284:ints-5(RNAi)_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057154:HeatShock_downregulated_miRNA-target |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058955:heatshock_upregulated_CE |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059598:HeatShock_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060434:pH4.33_vs_pH6.33_downrgulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADEsh |
| | | WBPaper00061340:AMsh |
| | | WBPaper00061340:AMso |
| | | WBPaper00061340:B_F_K_Kp_U_Y |
| | | WBPaper00061340:CEPso |
| | | WBPaper00061340:Excretory_duct_and_pore |
| | | WBPaper00061340:ILso |
| | | WBPaper00061340:Posterior_arcade_cell |
| | | WBPaper00061340:Tail_hypodermis |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:hsp-16.2-F44E5.4_19238 |
| | | WBPaper00061651:AMso_enriched |
| | | WBPaper00061651:AVK_enriched |
| | | WBPaper00061651:PHso_enriched |
| | | WBPaper00061651:SIA_enriched |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:daf-16(RNAi)_downregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_upregulated_N2 |
| | | WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13) |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064225:heat-shock_upregulated_protein |
| | | WBPaper00064505:tamoxifen_downregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064728:cpl-1(W32AY35A)_upregulated |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected |
| | | WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_upregulated_N2 |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | cgc4489_group_24 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_downregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030985:Erwinia_carotovora_downregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031184:acrylamide_downregulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00037147:heatshock_downregulated |
| | | WBPaper00037147:heatshock_upregulated |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00039866:ClassComp_daf-19_upregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00042574:JU1580_OrsayVirus_upregulated |
| | | WBPaper00044091:Bpseudomallei_induced_8h |
| | | WBPaper00044091:Bpseudomallei_induced_12h |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045437:Toxic-Se_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | [cgc5976]:class_1 |
| | | [cgc6390]:Cluster_C |
| | Interaction (27) |
| Map_info | Map | V | Position | 1.8633 | Error | 0.014042 |
| | Well_ordered |
| | Positive | Inside_rearr | mDf1 |
| | | | sDf29 |
| | | Positive_clone | H14N18 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | nDf42 |
| | Mapping_data | 2_point | 129 |
| | | | 840 |
| | | | 841 |
| | | Multi_point (26) |
| | | Pos_neg_data (12) |
| Reference (57) |
| Remark | Sequence connection from [Rahmani P, Moerman DG] |
| Method | Gene |
