| WBGene00006753 | SMap | S_parent | Sequence | K10D3 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-14 | Person_evidence | WBPerson261 |
| | | Sequence_name | K10D3.2 |
| | | Molecular_name | K10D3.2 |
| | | | K10D3.2.1 |
| | | | CE25055 |
| | | Other_name | CELE_K10D3.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | unc-14 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00142939 |
| | Allele (71) |
| | Legacy_information | e57 : very sluggish almost paralysed small and dumpyish tends to coil; some egg retention. ES3 ME0. NA6 (e157 etc.). |
| | | See also e57, e737, e866, e1119 |
| | | [C.elegansII] e57 : very sluggish, almost paralysed; small and dumpyish tends to coil; some egg retention; PVP defects.ES3 ME0. OA>5: e157 (multiple aspects of axon outgrowth affected; nerve processes contain large abnormal varicosities),e608, e866, e1119, etc. Cloned: cosmid rescue (R05H7). [Brenner 1974; McIntire et al. 1992; FK; MQ; MT; NJ] |
| | Strain | WBStrain00027263 |
| | | WBStrain00004088 |
| | | WBStrain00006262 |
| | | WBStrain00007580 |
| | | WBStrain00007626 |
| | | WBStrain00007627 |
| | | WBStrain00047375 |
| | | WBStrain00047377 |
| | | WBStrain00050646 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00012308 |
| | | 00012309 |
| | | 00012310 |
| | | 00012311 |
| | | 00012312 |
| | | 00012313 |
| | | 00012314 |
| | | 00012315 |
| | | 00012316 |
| | Ortholog (34) |
| | Structured_description | Concise_description | unc-14 encodes a RUN (RPIP8, UNC-14, and NESCA) domain-containing protein; unc-14 activity is required for axonogenesis (neurite outgrowth and axonal transport) and sex myoblast migration; in regulating axon guidance, UNC-14 functions together with the UNC-51 kinase, which binds and phosphorylates UNC-14, to properly localize the UNC-5 netrin receptor; UNC-14 also interacts with the kinesin light chain KLC-2 and thus appears to function as an adaptor protein that mediates kinesin-1-dependent transport of synaptic vesicle components; an UNC-14::GFP reporter fusion is expressed in neurons, including the VD and DD motor neurons, where it localizes to puncta in the axons or cell bodies; UNC-14 localization is dependent upon kinesin-1 (UNC-116 and KLC-2). | Paper_evidence | WBPaper00002845 |
| | | | | | WBPaper00004362 |
| | | | | | WBPaper00024595 |
| | | | | | WBPaper00024617 |
| | | | | | WBPaper00028376 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 13 Mar 2009 00:00:00 |
| | | Automated_description | Enables protein kinase binding activity and scaffold protein binding activity. Involved in regulation of protein localization and synaptic vesicle localization. Located in neuron projection. Expressed in several structures, including hypodermis; intestine; motor neurons; muscle cell; and uterus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 61. Is an ortholog of human RUSC1 (RUN and SH3 domain containing 1) and RUSC2 (RUN and SH3 domain containing 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0080239 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23625) |
| Molecular_info | Corresponding_CDS | K10D3.2 |
| | Corresponding_transcript | K10D3.2.1 |
| | Other_sequence (25) |
| | Associated_feature (23) |
| Experimental_info | RNAi_result | WBRNAi00025941 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090337 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00025940 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089791 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090178 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00050536 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00028223 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00003978 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090019 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1490 |
| | | Expr1491 |
| | | Expr12442 |
| | | Expr13385 |
| | | Expr13435 |
| | | Expr1023245 |
| | | Expr1032827 |
| | | Expr1154241 |
| | | Expr2017849 |
| | | Expr2035985 |
| | Drives_construct (22) |
| | Construct_product | WBCnstr00021076 |
| | | WBCnstr00034171 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050514:CEBP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00057140:pptr-1(tm3103)_upregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059440:GLP-1_represseded |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:CAN |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SMD |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:unc-13_19769-unc-13_278 |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:AUA_enriched |
| | | WBPaper00061651:AVG_enriched |
| | | WBPaper00061651:PVP_enriched |
| | | WBPaper00061651:RIF_enriched |
| | | WBPaper00061651:RIH_enriched |
| | | WBPaper00061651:RIR_enriched |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066085:hda-3(ok1991)_upregulated |
| | | cgc4386_cluster_5_5 |
| | | cgc4489_group_14 |
| | | WBPaper00005124:testosterone_10-9M_regulated |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00040963:Q50_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_A |
| | Interaction (36) |
| Map_info | Map | I | Position | 1.78971 | Error | 0.003402 |
| | Well_ordered |
| | Positive | Positive_clone | K10D3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | R05H7 |
| | Negative | Outside_rearr | sDf4 |
| | Mapping_data | 2_point | 16 |
| | | | 7102 |
| | | | 7103 |
| | | Multi_point | 5 |
| | | | 241 |
| | | | 1376 |
| | | | 4364 |
| | | | 4760 |
| | | Pos_neg_data (11) |
| Reference (71) |
| Method | Gene |
