WormBase Tree Display for Gene: WBGene00006746
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| WBGene00006746 | SMap | S_parent | Sequence | F41C6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-6 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F41C6.1 | ||||||||
| Molecular_name | F41C6.1 | ||||||||
| F41C6.1.1 | |||||||||
| CE04538 | |||||||||
| F41C6.1.2 | |||||||||
| Other_name | unc-106 | ||||||||
| CELE_F41C6.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | unc-6 | ||||||||
| DB_info | Database | AceView | gene | XH515 | |||||
| WormQTL | gene | WBGene00006746 | |||||||
| WormFlux | gene | WBGene00006746 | |||||||
| NDB | locus_tag | CELE_F41C6.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006746|UniProtKB=P34710 | |||||||
| family | PTHR10574 | ||||||||
| NCBI | gene | 180961 | |||||||
| RefSeq | protein | NM_076764.5 | |||||||
| SwissProt | UniProtAcc | P34710 | |||||||
| UniProt_GCRP | UniProtAcc | P34710 | |||||||
| OMIM | gene | 601614 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00142950 | ||||||||
| Allele (130) | |||||||||
| Legacy_information | e78 : slight kinker poor backing large healthy slightly fat; dorsal extensions of DD and VD neurons grow in aberrant directions fail to reach dorsal cord; ventral cord disorganized etc. ES3 ME1. NA4 (e7 e181 ev400 (pka unc-106 : uncoordinated high frequency of phasmid axon displacement)). | ||||||||
| See unc-6. | |||||||||
| See also ev400, n102, n165, n593, n594 | |||||||||
| [C.elegansII] e78 : slight kinker, poor backing; large, healthy, slightly fat; dorsal extensions of DD and VD neurons grow in aberrant directions fail to reach dorsal cord; ventral cord disorganized; abnormal gonad arms, etc. ES3 ME1. OA>20: e7, e181, ev400 (pka unc-106,uncoordinated, high frequency of phasmid axon displacement), n593, n594 etc. Some alleles (rh202, rh204, rh402 etc.) defective only in dorsalward migrations. Null alleles defective in both dorsalward and ventralward migrations. See also unc-5, unc-40. Cloned: encodes extracellular matrix component, laminin-related at N-term, homologous to vertebrate netrins. [Ishii et al. 1992; NW] | |||||||||
| Strain (70) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (60) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00001328 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00002247 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00002248 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006432 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006787 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018304 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00016913 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020581 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates circumferential axon migrations as well as migration of mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; in addition, UNC-6 mediates anchor cell (AC) invasion by regulating localization of the UNC-40 netrin receptor to the invasive plasma membrane of the AC, allowing for subsequent formation of an invasive membrane domain; a secreted molecule, UNC-6 is first expressed during embryogenesis in ventral epidermoblasts; additional expression is seen in neurons and sheath cells; UNC-6 is involved in both attractive and repulsive interactions mediated by the UNC-40 and UNC-5 netrin receptors, respectively. | Paper_evidence | WBPaper00002378 | |||||
| WBPaper00003642 | |||||||||
| WBPaper00004938 | |||||||||
| WBPaper00005417 | |||||||||
| WBPaper00005809 | |||||||||
| WBPaper00027335 | |||||||||
| WBPaper00032446 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 25 Aug 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable signaling receptor binding activity. Involved in several processes, including axon guidance; regulation of locomotion; and sex differentiation. Acts upstream of or within dendrite morphogenesis. Located in axon; basement membrane; and cytoplasm. Expressed in several structures, including P1; VA12; accessory cell; interneuron; and somatic neurons. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Is an ortholog of human NTN1 (netrin 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111153 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8029) | ||||
| Molecular_info | Corresponding_CDS | F41C6.1 | |||||||
| Corresponding_transcript | F41C6.1.1 | ||||||||
| F41C6.1.2 | |||||||||
| Other_sequence (22) | |||||||||
| Associated_feature (17) | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Chronogram678 | ||||||||
| Expr1590 | |||||||||
| Expr6024 | |||||||||
| Expr8561 | |||||||||
| Expr9253 | |||||||||
| Expr13722 | |||||||||
| Expr13723 | |||||||||
| Expr13724 | |||||||||
| Expr14553 | |||||||||
| Expr1010621 | |||||||||
| Expr1032820 | |||||||||
| Expr1150827 | |||||||||
| Expr2017900 | |||||||||
| Expr2036036 | |||||||||
| Drives_construct (24) | |||||||||
| Construct_product (30) | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (182) | |||||||||
| Interaction (245) | |||||||||
| Anatomy_function | WBbtf0504 | ||||||||
| WBbtf0505 | |||||||||
| WBProcess | WBbiopr:00000025 | ||||||||
| Map_info | Map | X | Position | -2.07556 | Error | 0.040208 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | stDp2 | |||||||
| mnDp30 | |||||||||
| Positive_clone | F41C6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| NJ#14 | |||||||||
| Negative | Outside_rearr | mcDf2 | |||||||
| Mapping_data | 2_point | 150 | |||||||
| 165 | |||||||||
| 177 | |||||||||
| 178 | |||||||||
| 185 | |||||||||
| 188 | |||||||||
| 236 | |||||||||
| 237 | |||||||||
| 3385 | |||||||||
| 7093 | |||||||||
| Multi_point (67) | |||||||||
| Pos_neg_data (20) | |||||||||
| Landmark_gene | |||||||||
| Reference (412) | |||||||||
| Method | Gene |
