WormBase Tree Display for Gene: WBGene00002248
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| WBGene00002248 | Evidence | Paper_evidence | WBPaper00006014 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_I | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | lam-3 | Person_evidence | WBPerson1052 | |||||
| Sequence_name | T22A3.8 | ||||||||
| Molecular_name | T22A3.8 | ||||||||
| T22A3.8.1 | |||||||||
| CE31067 | |||||||||
| Other_name | lama1/2 | Accession_evidence | EMBL | AF074902 | |||||
| CELE_T22A3.8 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lam-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lam | ||||||||
| Allele (147) | |||||||||
| Possibly_affected_by | WBVar02154115 | ||||||||
| WBVar02154116 | |||||||||
| Strain | WBStrain00027269 | ||||||||
| WBStrain00037801 | |||||||||
| WBStrain00050776 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00011601 | ||||||||
| 00011602 | |||||||||
| 00011603 | |||||||||
| 00011604 | |||||||||
| 00011605 | |||||||||
| 00011606 | |||||||||
| 00011607 | |||||||||
| 00011608 | |||||||||
| 00011609 | |||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00001328 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00002247 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006787 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006746 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00016913 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018304 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006432 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020581 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lam-3 encodes one of two C. elegans a laminin A subunits and is orthologous to human laminin alpha2; LAM-3 is a basement membrane component required for normal tissue development, including pharyngeal development; lam-3 is expressed in the pharynx and hypodermis, and also weakly in the intestine. | Paper_evidence | WBPaper00006014 | |||||
| WBPaper00040339 | |||||||||
| WBPaper00037071 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 26 Jan 2012 00:00:00 | ||||||||
| Automated_description | Predicted to be involved in animal organ morphogenesis and tissue development. Located in basement membrane. Expressed in several structures, including excretory canal; pharyngeal-intestinal valve; pharynx; somatic nervous system; and spermatheca. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; and myopia. Is an ortholog of human LAMA1 (laminin subunit alpha 1) and LAMA2 (laminin subunit alpha 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9884 | Homo sapiens | Paper_evidence | WBPaper00006014 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 08 Nov 2023 00:00:00 | ||||||||
| Potential_model | DOID:0110636 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6482) | |||||
| DOID:11830 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6482) | ||||||
| DOID:9884 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6482) | ||||||
| DOID:0110274 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6482) | ||||||
| Disease_relevance | lam-3 encodes a laminin A subunit orthologous to human laminin alpha2 (LAMA2), which when mutated leads to merosin-deficient congenital muscular dystrophy. | Homo sapiens | Paper_evidence | WBPaper00006014 | |||||
| Accession_evidence | OMIM | 156225 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 16 Nov 2011 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000023 | ||||||||
| Molecular_info | Corresponding_CDS | T22A3.8 | |||||||
| Corresponding_CDS_history | T22A3.8:wp80 | ||||||||
| Corresponding_transcript | T22A3.8.1 | ||||||||
| Other_sequence (22) | |||||||||
| Associated_feature | WBsf656886 | ||||||||
| WBsf656887 | |||||||||
| WBsf656888 | |||||||||
| WBsf656889 | |||||||||
| WBsf656890 | |||||||||
| WBsf985046 | |||||||||
| WBsf985047 | |||||||||
| WBsf218465 | |||||||||
| WBsf218466 | |||||||||
| Experimental_info | RNAi_result (24) | ||||||||
| Expr_pattern | Expr2621 | ||||||||
| Expr2624 | |||||||||
| Expr10827 | |||||||||
| Expr1028119 | |||||||||
| Expr1031322 | |||||||||
| Expr1157327 | |||||||||
| Expr2013009 | |||||||||
| Expr2031241 | |||||||||
| Drives_construct | WBCnstr00010875 | ||||||||
| WBCnstr00036362 | |||||||||
| Construct_product | WBCnstr00036362 | ||||||||
| Antibody | WBAntibody00000660 | ||||||||
| WBAntibody00000661 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (239) | |||||||||
| Interaction (53) | |||||||||
| Map_info | Map | I | Position | 5.05872 | Error | 0.000103 | |||
| Positive | Positive_clone | T22A3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (18) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
