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WormBase Tree Display for Gene: WBGene00002248

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Name Class

WBGene00002248EvidencePaper_evidenceWBPaper00006014
SMapS_parentSequenceCHROMOSOME_I
IdentityVersion1
NameCGC_namelam-3Person_evidenceWBPerson1052
Sequence_nameT22A3.8
Molecular_nameT22A3.8
T22A3.8.1
CE31067
Other_namelama1/2Accession_evidenceEMBLAF074902
CELE_T22A3.8Accession_evidenceNDBBX284601
Public_namelam-3
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlam
AlleleWBVar00090518Inferred_automaticallyFrom strain object: MT6550
WBVar00156538
WBVar00156539
WBVar00156540
WBVar00156541
WBVar00156542
WBVar00236894
WBVar00598039
WBVar01343689
WBVar01489977
WBVar01499739
WBVar00344250
WBVar00344251
WBVar00344252
WBVar00344253
WBVar00344254
WBVar00344255
WBVar00344256
WBVar00344257
WBVar00344258
WBVar02128393
WBVar00344259
WBVar00667628
WBVar02128394
WBVar00667629
WBVar00344260
WBVar00344261
WBVar00667630
WBVar02128395
WBVar00667631
WBVar00344262
WBVar00667632
WBVar00344263
WBVar00344264
WBVar00667633
WBVar00344265
WBVar00667634
WBVar00667635
WBVar00344266
WBVar01662794
WBVar00667636
WBVar00344267
WBVar00667637
WBVar01662795
WBVar00344268
WBVar00667638
WBVar00344269
WBVar00344270
WBVar00667639
WBVar00240416
WBVar00344271
WBVar00667640
WBVar00344272
WBVar00667641
WBVar00667642
WBVar00344273
WBVar00344274
WBVar00667643
WBVar00344275
WBVar00667644
WBVar00344276
WBVar00667645
WBVar00344277
WBVar00667646
WBVar00667647
WBVar00344278
WBVar00344279
WBVar00667648
WBVar00667649
WBVar00344280
WBVar00667650
WBVar00344281
WBVar00667651
WBVar00344282
WBVar00667652
WBVar00667653
WBVar00667654
WBVar00667655
WBVar00667656
WBVar00667657
WBVar00667658
WBVar00667659
WBVar01499786
WBVar00667660
WBVar00667661
WBVar00667662
WBVar01499054
WBVar00667663
WBVar00667664
WBVar00667665
WBVar00667666
WBVar00667667
WBVar00667668
WBVar00667669
WBVar00667670
WBVar00667671
WBVar01911861
WBVar00667672
WBVar00667673
WBVar00667674
WBVar00667675
WBVar01392017
WBVar00667676
WBVar00667677
WBVar00667678
WBVar00667679
WBVar00667680
WBVar00667681
WBVar00667682
WBVar00667683
WBVar00667684
WBVar00667685
WBVar00667686
WBVar01532127
WBVar01532128
WBVar00667687
WBVar00667688
WBVar00667689
WBVar00667690
WBVar00667691
WBVar00667692
WBVar00667693
WBVar00667694
WBVar00667695
WBVar00667696
WBVar00667697
WBVar00667698
WBVar00667699
WBVar00667700
WBVar00667701
WBVar00667702
WBVar00667703
WBVar00667704
WBVar02151186
WBVar00667705
WBVar00667706
WBVar00667707
WBVar00667708
WBVar00667709
WBVar02001739
WBVar00667710
WBVar00667711
WBVar00667712
WBVar00667713
WBVar01432803
WBVar01498959
WBVar00093219
Possibly_affected_byWBVar02154115
WBVar02154116
StrainWBStrain00027269
WBStrain00037801
WBStrain00050776
RNASeq_FPKM (74)
GO_annotation00011601
00011602
00011603
00011604
00011605
00011606
00011607
00011608
00011609
Ortholog (46)
ParalogWBGene00001328Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002247Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006787Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006746Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00016913Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00018304Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006432Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00020581Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionlam-3 encodes one of two C. elegans a laminin A subunits and is orthologous to human laminin alpha2; LAM-3 is a basement membrane component required for normal tissue development, including pharyngeal development; lam-3 is expressed in the pharynx and hypodermis, and also weakly in the intestine.Paper_evidenceWBPaper00006014
WBPaper00040339
WBPaper00037071
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated26 Jan 2012 00:00:00
Automated_descriptionPredicted to be involved in animal organ morphogenesis and tissue development. Located in basement membrane. Expressed in several structures, including excretory canal; pharyngeal-intestinal valve; pharynx; somatic nervous system; and spermatheca. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; and myopia. Is an ortholog of human LAMA1 (laminin subunit alpha 1) and LAMA2 (laminin subunit alpha 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:9884Homo sapiensPaper_evidenceWBPaper00006014
Curator_confirmedWBPerson324
Date_last_updated08 Nov 2023 00:00:00
Potential_modelDOID:0110636Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6482)
DOID:11830Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6482)
DOID:9884Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6482)
DOID:0110274Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6482)
Disease_relevancelam-3 encodes a laminin A subunit orthologous to human laminin alpha2 (LAMA2), which when mutated leads to merosin-deficient congenital muscular dystrophy.Homo sapiensPaper_evidenceWBPaper00006014
Accession_evidenceOMIM156225
Curator_confirmedWBPerson324
Date_last_updated16 Nov 2011 00:00:00
Models_disease_in_annotationWBDOannot00000023
Molecular_infoCorresponding_CDST22A3.8
Corresponding_CDS_historyT22A3.8:wp80
Corresponding_transcriptT22A3.8.1
Other_sequence (22)
Associated_featureWBsf656886
WBsf656887
WBsf656888
WBsf656889
WBsf656890
WBsf985046
WBsf985047
WBsf218465
WBsf218466
Experimental_infoRNAi_result (24)
Expr_patternExpr2621
Expr2624
Expr10827
Expr1028119
Expr1031322
Expr1157327
Expr2013009
Expr2031241
Drives_constructWBCnstr00010875
WBCnstr00036362
Construct_productWBCnstr00036362
AntibodyWBAntibody00000660
WBAntibody00000661
Microarray_results (27)
Expression_cluster (239)
Interaction (53)
Map_infoMapIPosition5.05872Error0.000103
PositivePositive_cloneT22A3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (18)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene