WormBase Tree Display for Gene: WBGene00016913
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| WBGene00016913 | SMap | S_parent | Sequence | C54D1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lam-2 | Person_evidence | WBPerson1052 | |||||
| Sequence_name | C54D1.5 | ||||||||
| Molecular_name | C54D1.5 | ||||||||
| C54D1.5.1 | |||||||||
| CE45033 | |||||||||
| Other_name | CELE_C54D1.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | lam-2 | ||||||||
| DB_info | Database | AceView | gene | XH764 | |||||
| WormQTL | gene | WBGene00016913 | |||||||
| WormFlux | gene | WBGene00016913 | |||||||
| NDB | locus_tag | CELE_C54D1.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00016913|UniProtKB=Q18823 | |||||||
| family | PTHR10574 | ||||||||
| NCBI | gene | 180980 | |||||||
| RefSeq | protein | NM_076803.7 | |||||||
| SwissProt | UniProtAcc | Q18823 | |||||||
| UniProt_GCRP | UniProtAcc | Q18823 | |||||||
| OMIM | gene | 150292 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 07 Sep 2006 08:03:16 | WBPerson2970 | Name_change | CGC_name | lam-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lam | ||||||||
| Allele (95) | |||||||||
| Possibly_affected_by | WBVar02152919 | ||||||||
| Strain | WBStrain00047389 | ||||||||
| WBStrain00047391 | |||||||||
| WBStrain00054722 | |||||||||
| WBStrain00053139 | |||||||||
| WBStrain00055597 | |||||||||
| WBStrain00055596 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00062469 | ||||||||
| 00062470 | |||||||||
| 00062471 | |||||||||
| 00062472 | |||||||||
| 00062473 | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00001328 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00002247 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00002248 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006432 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006746 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006787 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018304 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020581 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lam-2 encodes a laminin gamma subunit; lam-2 activity is required for embryonic development and for regulation of muscle arm extension; loss of lam-2 function via large-scale RNAi screens results in embryonic, larval, and adult lethality, sterility, body morphology defects, and abnormal locomotion. | Paper_evidence | WBPaper00004651 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00006395 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00027002 | |||||||||
| WBPaper00027119 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Jul 2007 00:00:00 | ||||||||
| Automated_description | Involved in positive regulation of locomotion. Predicted to be located in basement membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa; lung small cell carcinoma; and lung squamous cell carcinoma. Is an ortholog of human LAMC1 (laminin subunit gamma 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:5409 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6493) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6493) | ||||||
| DOID:3907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6493) | ||||||
| DOID:3209 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6493) | ||||||
| Molecular_info | Corresponding_CDS | C54D1.5 | |||||||
| Corresponding_CDS_history | C54D1.5:wp214 | ||||||||
| Corresponding_transcript | C54D1.5.1 | ||||||||
| Other_sequence (30) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (34) | ||||||||
| Expr_pattern | Expr14840 | ||||||||
| Expr1016698 | |||||||||
| Expr1037258 | |||||||||
| Expr1147099 | |||||||||
| Expr2013008 | |||||||||
| Expr2031240 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (188) | |||||||||
| Interaction (38) | |||||||||
| Map_info | Map | X | Position | -1.82438 | |||||
| Positive | Positive_clone | C54D1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00029024 | ||||||||
| WBPaper00032118 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040382 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00061662 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
