WormBase Tree Display for Gene: WBGene00006741

WBGene00006741 SMap: S_parent: Sequence: K03E6
  Identity: Version: 1
    Name: CGC_name: unc-1 Person_evidence: WBPerson261
      Sequence_name: K03E6.5
      Molecular_name: K03E6.5a
        K03E6.5a.1
        CE28585
        K03E6.5b
        CE42275
        K03E6.5b.1
      Other_name: unc-102
        CELE_K03E6.5 Accession_evidence: NDB BX284606
      Public_name: unc-1
    DB_info: Database: AceView gene XB678
        WormQTL gene WBGene00006741
        WormFlux gene WBGene00006741
        NDB locus_tag CELE_K03E6.5
        Panther gene CAEEL|WormBase=WBGene00006741|UniProtKB=Q21190
          family PTHR10264
        NCBI gene 180458
        RefSeq protein NM_001129690.5
            NM_075801.7
        SwissProt UniProtAcc Q21190
        TrEMBL UniProtAcc G5ED08
        UniProt_GCRP UniProtAcc Q21190
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (97)
    Legacy_information: lass 1 (loss-of-function) e719 : putative null recessive kinker. ES3 NA (recessive) > 10. unc-1 Class 3 (neomorph/antimorph) e94sd (former reference allele) : recessive kinker e94/+ is weak coiler ES2 ME2; e1598dm (pka unc-102) : both homozygote and e1598/+ are strong coilers resistant to aldicarb (cholinesterase inhibitor); intragenic revertants of e1598 have Class 1 phenotype. ES3 ME0. NA (dominant) > 8. Complex complementation among unc-1 alleles.
      See unc-1.
      See also e1598, e2380, e2381, n494, n496, n774, n775, n779, n782, n783, n784, n1166, n1167, n1200, n1201, n1202, n1203, n1204, n1205, n1206, n1207, n1208, n1209
      [C.elegansII] e719 : recessive kinker, putative null. Suppresses anaesthetic hypersensitivity of unc-79 and unc-80 mutants. ES3 ME1. OA>10(recessive): e50, e68, e114 (anomalous allele, transdominant suppressor of n494sd), etc. Also neomorph/antimorph gf alleles: e94sd (former reference allele, recessive kinker; e94/+ is weak coiler. ES2 ME2), e1598dm (pka unc-102, both homozygote and e1598/+ are strong Ric coilers; intragenic revertants of e1598 resemble e719. ES3 ME0). OA>8 (dominant and semidominant);n496, n775 (strongly dominant), n494 (weaklysemidominant), etc. Complex complementation among unc-1 alleles. [Park and Horvitz 1986a; Morgan and Sedensky 1994; CW]
    Strain (37)
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (29)
    Paralog (9)
    Structured_description: Concise_description: unc-1 encodes one of ten C. elegans stomatin-like proteins (SLPs) homologous to human erythrocyte surface protein band 7.2 (EPB72/Stomatin) (OMIM:133090; deficient in stomatocytosis); UNC-1 activity regulates electrical coupling between body wall muscles and is required in neurons for normal locomotion; unc-1 is also required for anesthetic sensitivity; an unc-1 promoter::DsRED2 fusion is expressed in body wall muscle, vulval muscle, anal-depressor muscle, stomatointestinal muscle, nearly all ventral cord motor neurons and the nerve ring; in neurons and body wall muscle, UNC-1 colocalizes with UNC-9, an innexin, at intercellular junctions; unc-24, which also encodes a stomatin homolog, is epistatic to unc-1 and required for UNC-1 localization in the nerve ring. Paper_evidence: WBPaper00000031
            WBPaper00004649
            WBPaper00030879
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 18 Jul 2008 00:00:00
      Automated_description: Enables ion channel regulator activity. Involved in positive regulation of cell communication by electrical coupling and response to xenobiotic stimulus. Located in axon and gap junction. Expressed in several structures, including enteric muscle; ganglia; head neurons; somatic nervous system; and vulval muscle. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K03E6.5a
      K03E6.5b
    Corresponding_CDS_history: K03E6.5:wp188
    Corresponding_transcript: K03E6.5a.1
      K03E6.5b.1
    Other_sequence (59)
    Associated_feature: WBsf670099
      WBsf1003931
      WBsf1003932
      WBsf1022206
      WBsf1022207
      WBsf1022208
      WBsf236994
      WBsf236995
      WBsf236996
  Experimental_info: RNAi_result: WBRNAi00103042 Inferred_automatically: RNAi_primary
      WBRNAi00049837 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr527
      Expr887
      Expr3407
      Expr4819
      Expr1022667
      Expr1032816
      Expr1153550
      Expr2017854
      Expr2035990
    Drives_construct: WBCnstr00012258
      WBCnstr00012259
      WBCnstr00012423
      WBCnstr00014590
      WBCnstr00019884
      WBCnstr00034181
    Construct_product: WBCnstr00012423
      WBCnstr00023065
      WBCnstr00034181
      WBCnstr00042106
    Antibody: WBAntibody00000361
      WBAntibody00000750
      WBAntibody00001262
    Microarray_results (22)
    Expression_cluster (203)
    Interaction: WBInteraction000000035
      WBInteraction000000542
      WBInteraction000000543
      WBInteraction000000881
      WBInteraction000000982
      WBInteraction000000983
      WBInteraction000000984
      WBInteraction000001344
      WBInteraction000001345
      WBInteraction000001736
      WBInteraction000001975
      WBInteraction000003004
      WBInteraction000004114
      WBInteraction000005393
      WBInteraction000005394
      WBInteraction000005395
      WBInteraction000005396
      WBInteraction000005397
      WBInteraction000005407
      WBInteraction000005839
      WBInteraction000028453
      WBInteraction000031877
      WBInteraction000031878
      WBInteraction000031879
      WBInteraction000052184
      WBInteraction000052194
      WBInteraction000052199
      WBInteraction000052210
      WBInteraction000052267
      WBInteraction000052603
      WBInteraction000052604
      WBInteraction000052621
      WBInteraction000126290
      WBInteraction000126291
      WBInteraction000126292
      WBInteraction000126293
      WBInteraction000126294
      WBInteraction000126295
      WBInteraction000126302
      WBInteraction000126311
      WBInteraction000126321
      WBInteraction000126325
      WBInteraction000126328
      WBInteraction000126329
      WBInteraction000126344
      WBInteraction000126346
      WBInteraction000126347
      WBInteraction000126348
      WBInteraction000126349
      WBInteraction000126967
      WBInteraction000127008
      WBInteraction000127179
      WBInteraction000127483
      WBInteraction000127534
      WBInteraction000133283
      WBInteraction000135273
      WBInteraction000135319
      WBInteraction000136658
      WBInteraction000136675
      WBInteraction000136676
      WBInteraction000136677
      WBInteraction000136678
      WBInteraction000137575
      WBInteraction000143768
      WBInteraction000148184
      WBInteraction000152014
      WBInteraction000166393
      WBInteraction000166412
      WBInteraction000166422
      WBInteraction000171958
      WBInteraction000176259
      WBInteraction000180840
      WBInteraction000186197
      WBInteraction000186198
      WBInteraction000211631
      WBInteraction000227005
      WBInteraction000227006
      WBInteraction000267779
      WBInteraction000267780
      WBInteraction000267781
      WBInteraction000267782
      WBInteraction000267783
      WBInteraction000267784
      WBInteraction000267785
      WBInteraction000299290
      WBInteraction000318639
      WBInteraction000338753
      WBInteraction000360186
      WBInteraction000364441
      WBInteraction000364442
      WBInteraction000364443
      WBInteraction000364444
      WBInteraction000364445
      WBInteraction000402380
      WBInteraction000446245
      WBInteraction000446246
      WBInteraction000446247
      WBInteraction000446248
      WBInteraction000446249
      WBInteraction000446250
      WBInteraction000446251
      WBInteraction000446252
      WBInteraction000446253
      WBInteraction000446254
      WBInteraction000446255
      WBInteraction000446256
      WBInteraction000446257
      WBInteraction000446258
      WBInteraction000469600
      WBInteraction000469601
      WBInteraction000500600
      WBInteraction000501524
      WBInteraction000502986
      WBInteraction000519107
      WBInteraction000519119
      WBInteraction000519120
      WBInteraction000521622
      WBInteraction000525187
      WBInteraction000535491
      WBInteraction000535492
      WBInteraction000540537
      WBInteraction000541680
      WBInteraction000551581
      WBInteraction000556982
      WBInteraction000556983
      WBInteraction000556984
      WBInteraction000556985
      WBInteraction000561573
      WBInteraction000561574
  Map_info: Map: X Position: -18.7759 Error: 0.006952
    Well_ordered
    Positive: Inside_rearr: mnDp69
        meDf3
        meDf5
        mnDp52
        yDp13
        yDp15
        meDf2
        meDf6
      Positive_clone: C04D1
        K03E6 Author_evidence: (rescues when
          Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Negative_clone: C55D6
        T17A11
    Mapping_data: 2_point (12)
      Multi_point (38)
      Pos_neg_data (46)
    Landmark_gene
  Reference (109)
  Method: Gene