WormBase Tree Display for Interaction: WBInteraction000541680
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| WBInteraction000541680 | Interaction_type | Regulatory | |||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00006761 | Interactor_type | Trans_regulator | |
| WBGene00006741 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr3407 | ||||
| Interaction_summary | In unc-24(0) animals, UNC-1 is not distributed to the cell membrane but remains in the perinuclear region, presumably in the endoplasmic reticulum. In lipid raft preparations of unc-24(0) animals, UNC-1 is primarily localized to the same fractions that normally contain rafts. However, the distribution of UNC-1 was much broader; some UNC-1 was noted in the high-density membrane pellet. The 32-kDa form of UNC-1 is the primary form seen in rafts of unc-24(0) animals. Earlier results with total protein from unc-24(0) indicated that the 32-kDa form is the predominant form of the protein in this mutant. | ||||
| Detection_method | Western | ||||
| Regulation_result | Negative_regulate | Subcellular_localization | perinuclear region | ||
| Paper | WBPaper00024234 |
