WormBase Tree Display for Gene: WBGene00006367

WBGene00006367 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 2
    Name: CGC_name: sym-2 Person_evidence: WBPerson252
      Sequence_name: ZK1067.6
      Molecular_name: ZK1067.6a
        ZK1067.6a.1
        CE35148
        ZK1067.6b
        CE03707
        ZK1067.6b.1
      Other_name: CELE_ZK1067.6 Accession_evidence: NDB BX284602
      Public_name: sym-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 19 Aug 2005 11:42:03 WBPerson2970 Event: Acquires_merge: WBGene00014211
      Acquires_merge: WBGene00014211
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sym
    Allele (153)
    Legacy_information: [Herman RK] sym-2(mn617) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation
    Strain: WBStrain00034404
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (49)
    Paralog: WBGene00013703 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022253 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020936 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: sym-2 encodes a predicted RNA binding protein that contains three RNA recognition motifs (RRMs) similar to those of Drosophila Fusilli and mammalian hnRNP F and H; genetic analyses indicate that, during embryonic development, sym-2 functions redundantly with mec-8, which also encodes an RRM-containing protein, to affect the structure of body wall muscles or their attachment to the body cuticle, perhaps by regulating maturation of transcripts essential for muscle development. Paper_evidence: WBPaper00003663
            WBPaper00024639
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 04 May 2006 00:00:00
      Automated_description: Predicted to enable mRNA binding activity. Involved in embryo development; embryonic body morphogenesis; and multicellular organismal movement. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Is an ortholog of human ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 (epithelial splicing regulatory protein 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111639 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25966)
  Molecular_info: Corresponding_CDS: ZK1067.6a
      ZK1067.6b
    Corresponding_CDS_history: ZK1067.6:wp106
    Corresponding_transcript: ZK1067.6a.1
      ZK1067.6b.1
    Associated_feature (20)
  Experimental_info: RNAi_result: WBRNAi00062554 Inferred_automatically: RNAi_primary
      WBRNAi00095006 Inferred_automatically: RNAi_primary
      WBRNAi00062552 Inferred_automatically: RNAi_primary
      WBRNAi00022509 Inferred_automatically: RNAi_primary
      WBRNAi00038138 Inferred_automatically: RNAi_primary
      WBRNAi00062553 Inferred_automatically: RNAi_primary
      WBRNAi00059094 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1019298
      Expr1032566
      Expr1162524
      Expr2017180
      Expr2035316
    Drives_construct: WBCnstr00034387
    Construct_product: WBCnstr00034387
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00035197:fer-1_downregulated
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00043945:MeHg_upregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046121:endoderm_unique
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046499:AMPK_regulated
      WBPaper00046887:WNT-target
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053020:sid-3(ok973)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055648:male-vas-deferens_expressed
      WBPaper00055648:spermatheca_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1_upregulated_L4_transcript
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060445:ikb-1(nr2027)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061106:endu-2(tm4977)_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AMso
      WBPaper00061340:B
      WBPaper00061340:Coelomocyte
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:F_U
      WBPaper00061340:g1A_g1P
      WBPaper00061340:g1A_parent
      WBPaper00061340:g2
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:Glia
      WBPaper00061340:hyp1V_and_ant_arc_V
      WBPaper00061340:K_Kprime
      WBPaper00061340:mc3
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Parents_of_U_F_B_DVA
      WBPaper00061340:Parent_of_g1P_I3
      WBPaper00061340:Parent_of_K_Kprime
      WBPaper00061340:Parent_of_PVP_and_rect_V
      WBPaper00061340:pm6
      WBPaper00061340:pm7
      WBPaper00061340:pm8
      WBPaper00061340:rect_D
      WBPaper00061340:Seam_cell
      WBPaper00061340:T
      WBPaper00061340:Y
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:bus-8_3160-K04H4.2_2324
      WBPaper00061527:ifd-1-ifp-1
      WBPaper00061651:Coelomocyte_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062534:fat-P-80_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065841:12_0
      WBPaper00065841:41_0
      WBPaper00065841:41_1
      WBPaper00065841:41_2
      WBPaper00065841:43_0
      WBPaper00065841:69_0
      WBPaper00065841:72_0
      WBPaper00065841:78_0
      WBPaper00065841:89_0
      WBPaper00065841:100_0
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_5_5
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:FedUp
      WBPaper00034739:N2lessDR1350
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037695:WC_5-day
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_B
    Interaction (30)
  Map_info: Map: II Position: 1.09265 Error: 0.000921
    Positive: Positive_clone: ZK1067 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 7090
        7091
  Reference (18)
  Method: Gene