WormBase Tree Display for Gene: WBGene00006363

WBGene00006363 Evidence: Paper_evidence: WBPaper00005543
  SMap: S_parent: Sequence: F35D2
  Identity: Version: 1
    Name: CGC_name: syd-1 Person_evidence: WBPerson105
            WBPerson293
      Sequence_name: F35D2.5
      Molecular_name: F35D2.5a
        F35D2.5a.1
        CE33391
        F35D2.5c
        CE33392
        F35D2.5c.1
        F35D2.5c.2
      Other_name: CELE_F35D2.5 Accession_evidence: NDB BX284602
      Public_name: syd-1
    DB_info: Database: AceView gene 2H876
        WormQTL gene WBGene00006363
        WormFlux gene WBGene00006363
        NDB locus_tag CELE_F35D2.5
        Panther gene CAEEL|WormBase=WBGene00006363|UniProtKB=Q86NH1
          family PTHR46150
        NCBI gene 174230
        RefSeq protein NM_001026975.4
            NM_001383891.2
        SwissProt UniProtAcc Q86NH1
        TREEFAM TREEFAM_ID TF323458
        UniProt_GCRP UniProtAcc Q86NH1
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: syd
    Allele (120)
    Strain: WBStrain00032087
      WBStrain00037967
      WBStrain00005369
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (39)
    Paralog: WBGene00015267 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: syd-1 encodes a protein that contains a Rho-GTPase-like activating domain as well as PDZ and C2 domains; during neuronal development, SYD-1 is required cell autonomously to positively regulate synaptogenesis; in regulating synapse development, SYD-1 functions as a positive regulator of SYD-2/liprin through direct interaction with ELKS-1, a pre-synaptic protein also required for synapse development; in turn, SYD-1 activity is regulated by RSY-1, a negative regulator of synaptogenesis, with which it also interacts physically; SYD-1 is expressed in neurons and localizes to presynaptic regions. Paper_evidence: WBPaper00005543
            WBPaper00028808
          Curator_confirmed: WBPerson1843
          Date_last_updated: 08 Mar 2010 00:00:00
      Automated_description: Enables GTPase activator activity; Roundabout binding activity; and small GTPase binding activity. Involved in cell projection organization; cellular localization; and locomotion. Located in presynaptic membrane. Expressed in nerve ring and neurons. Is an ortholog of human SYDE2 (synapse defective Rho GTPase homolog 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F35D2.5a
      F35D2.5c
    Corresponding_CDS_history: F35D2.5:wp84
      F35D2.5:wp92
      F35D2.5b:wp93
      F35D2.5b:wp274
    Corresponding_transcript: F35D2.5a.1
      F35D2.5c.1
      F35D2.5c.2
    Other_sequence (15)
    Associated_feature: WBsf650240
      WBsf665701
      WBsf665702
      WBsf665703
      WBsf665704
      WBsf665705
      WBsf665706
      WBsf988490
      WBsf988491
      WBsf988492
      WBsf988493
      WBsf988494
      WBsf988495
      WBsf1012557
      WBsf1012558
  Experimental_info: RNAi_result: WBRNAi00082910 Inferred_automatically: RNAi_primary
      WBRNAi00046330 Inferred_automatically: RNAi_primary
      WBRNAi00031774 Inferred_automatically: RNAi_primary
      WBRNAi00014326 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00000711
      WBCnstr00000728
      WBCnstr00010752
      WBCnstr00034391
    Construct_product: WBCnstr00000728
      WBCnstr00007017
      WBCnstr00010752
      WBCnstr00010753
      WBCnstr00012368
      WBCnstr00012375
      WBCnstr00018295
      WBCnstr00021865
      WBCnstr00034391
      WBCnstr00038079
    Antibody: WBAntibody00000569
    Microarray_results (33)
    Expression_cluster: WBPaper00024970:GABAergic_neuron_specific
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:A-class-motor-neurons_CoreEnriched
      WBPaper00037950:A-class-motor-neurons_embryo_enriched
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_embryo_enriched
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00044736:flat_dev_expression
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045861:wdr-5(ok1417)_upregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_tiling
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050231:male_enriched
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055648:nerve-ring_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058678:DAF-12_upregulated_PVD
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADE
      WBPaper00061340:AIA
      WBPaper00061340:AIY
      WBPaper00061340:AIZ
      WBPaper00061340:ALN
      WBPaper00061340:AUA
      WBPaper00061340:AVG
      WBPaper00061340:AVJ
      WBPaper00061340:CEP
      WBPaper00061340:DA
      WBPaper00061340:DA_DB
      WBPaper00061340:DB
      WBPaper00061340:DD
      WBPaper00061340:DVA
      WBPaper00061340:FLP
      WBPaper00061340:I5
      WBPaper00061340:IL1
      WBPaper00061340:MC
      WBPaper00061340:OLL
      WBPaper00061340:OLQ
      WBPaper00061340:RIA
      WBPaper00061340:RIC
      WBPaper00061340:RIM
      WBPaper00061340:RIS
      WBPaper00061340:RME
      WBPaper00061340:SIA
      WBPaper00061340:SIB
      WBPaper00061340:SMB
      WBPaper00061340:SMD
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:ckr-1-T09B9.3
      WBPaper00061527:syd-1_2945-unc-41_2170
      WBPaper00061651:RIA_enriched
      WBPaper00061818:ELKS-1_interacting
      WBPaper00061952:daf-18(nr2037)_upregulated
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062156:jmjd-5(zr1234)_downregulated_germline
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:17_0
      WBPaper00065841:19_0
      WBPaper00065841:36_2
      WBPaper00065841:58_1
      WBPaper00065841:83_0
      WBPaper00065841:87_0
      WBPaper00065841:100_0
      WBPaper00065841:145_0
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_2
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Erwinia_carotovora_downregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041906:I-4317_vs_OP50_10d
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042548:miRISC_enriched
      WBPaper00045374:Benzene_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:xpa-1_UV_downregulated
    Interaction (51)
  Map_info: Map: II Position: 0.504817 Error: 4.2e-05
    Positive: Positive_clone: F35D2 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4188
        4715
        4733
        5534
    Pseudo_map_position
  Reference (52)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene