str-2 encodes a seven-transmembrane protein that is a candidate olfactory receptor; STR-2::GFP reporter fusions are expressed in chemosensory neurons including the AWC neuron, in which STR-2 is expressed asymmetrically, in either the AWCL or AWCR neuron, but not both; asymmetric STR-2 expression in AWC is regulated by axon contact, innexins and a calcium and MAPKKK signaling pathway; STR-2 localizes to cilia; loss of str-2 function via RNAi has been reported to result in extended life span.
Predicted to enable G protein-coupled olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and olfactory behavior. Located in non-motile cilium. Expressed in ASIL; ASIR; AWC-ON; AWCL; and AWCR.
Sequence connection from [Troemel ER, Dwyer HA, Bargmann CI]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.