WormBase Tree Display for Gene: WBGene00004989

WBGene00004989 SMap: S_parent: Sequence: T08A9
  Identity: Version: 1
    Name: CGC_name: spp-4
      Sequence_name: T08A9.8
      Molecular_name: T08A9.8
        T08A9.8.1
        CE04923
      Other_name: CELE_T08A9.8 Accession_evidence: NDB BX284606
      Public_name: spp-4
    DB_info: Database: AceView gene XH938
        WormQTL gene WBGene00004989
        WormFlux gene WBGene00004989
        NDB locus_tag CELE_T08A9.8
        Panther gene CAEEL|WormBase=WBGene00004989|UniProtKB=Q22338
          family PTHR21579
        NCBI gene 188266
        RefSeq protein NM_076836.6
        TREEFAM TREEFAM_ID TF343148
        TrEMBL UniProtAcc Q22338
        UniProt_GCRP UniProtAcc Q22338
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:37 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spp
    Allele (15)
    RNASeq_FPKM (74)
    Ortholog (19)
    Paralog (12)
    Structured_description: Concise_description: spp-4 encodes an antimicrobial peptide that belongs to the SPP-protein family, called caenopores, with structural similarity to saposin-like proteins (SAPLIPs), the amoebapores and the mammalian NK-lysin and granulysin; caenopores are part of the worm's innate immune system and interact with and eliminate bacteria via membrane pore-forming activity; C. elegans has at least 33 putative SPP proteins; phylogenetic analysis indicates that spp-4 is most similar to spp-2, spp-5 and spp-6. Paper_evidence: WBPaper00035289
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Sep 2013 00:00:00
      Automated_description: Enriched in hypodermis; intestine; male-specific anatomical entity; muscle cell; and neurons based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including daf-16; daf-2; and dpy-10 based on microarray and RNA-seq studies. Is affected by twenty-four chemicals including Heme; methylmercuric chloride; and bisphenol S based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Saposin B type, region 2; Saposin B type domain; Saposin-like; Phosphorylation site; and Saposin-like type B, region 2. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T08A9.8
    Corresponding_transcript: T08A9.8.1
    Other_sequence (89)
    Associated_feature: WBsf237570
  Experimental_info: RNAi_result: WBRNAi00075981 Inferred_automatically: RNAi_primary
      WBRNAi00082193 Inferred_automatically: RNAi_primary
      WBRNAi00018422 Inferred_automatically: RNAi_primary
      WBRNAi00052829 Inferred_automatically: RNAi_primary
      WBRNAi00035334 Inferred_automatically: RNAi_primary
      WBRNAi00082200 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1027235
      Expr1156431
      Expr2016082
      Expr2034318
    Drives_construct: WBCnstr00035288
    Construct_product: WBCnstr00035288
    Microarray_results (16)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00036738:4uM_Heme_downregulated
      WBPaper00037950:A-class-motor-neurons_embryo_enriched
      WBPaper00037950:AVE-neuron_embryo_enriched
      WBPaper00037950:bodywall-muscle_embryo_enriched
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00038118:aak-2(gt33)_downregulated
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00040990:PA14_downregulated
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00042215:wdr-23(tm1817)_downregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044316:CH3HgCl_2.0uM_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049018:ham-3(RNAi)_upregulated
      WBPaper00049098:heat-repressed_hrde-1(tm1200)
      WBPaper00049098:heat-repressed_N2
      WBPaper00049217:DAF-16_downregulated
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049484:elt-2(RNAi)_downregulated_L4
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1
      WBPaper00050225:flp-6(RNAi)_downregulated
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051352:Long-Term-Association-Memory_downregulated
      WBPaper00051388:Glucose-diet_downregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053020:sid-3(ok973)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:clk-1(qm30)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055137:S.maltophilia_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056218:daf-16(mu86)_downregulated_Day5
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056284:ints-2(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056586:kri-1(ok1251)_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059604:fluvastatin_upregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_upregulated_N2
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060273:isp-1(qm150)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060703:nas-38(ok3407)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061040:FW1256_upregulated
      WBPaper00061081:E.faecalis_downregulated_N2
      WBPaper00061106:endu-2(tm4977)_upregulated
      WBPaper00061274:hypergravity_15xg_downregulated
      WBPaper00061340:AIZ
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:gst-26-pho-1_10767
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062056:dpl-1(n2994)_downregulated
      WBPaper00062056:lin-15B(n744)_downregulated
      WBPaper00062056:lin-35(n745)_downregulated
      WBPaper00062056:lin-37(n758)_downregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062237:dnj-21(RNAi)_downregulated_protein
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062347:blmp-1(tm548)_downregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062446:nhr-8(ok186)_downregulated
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00062606:rotenone_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064494:postdauer_downregulated_AWA
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064841:tent-5(tm3504)_downregulated_transcript
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065005:sams-4(RNAi)_downregulated
      WBPaper00065005:sams-5(RNAi)_downregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065215:microgravity_downregulated_DESeq2
      WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065392:Lb.gasseri_downregulated
      WBPaper00065392:Lb.rhamnosus_upregulated
      WBPaper00065841:3_1
      WBPaper00065841:3_2
      WBPaper00065877:rege-1(imm070)_upregulated_OP50
      WBPaper00065877:rege-1(imm070)_upregulated_PA14
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066118:cyclobutrifluram_downregulated
      WBPaper00066163:crtc-1(wbm18)_downregulated_N2
      WBPaper00066163:crtc-1(wbm18)_downregulated_set-2(ok952)
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4386_cluster_1_2
      cgc4489_group_4
      WBPaper00026629:L2_male_enriched
      WBPaper00026980:intestine_enriched
      WBPaper00028789:PA14_vs_gacA_downregulated_4hr
      WBPaper00028789:PA14_vs_gacA_downregulated_8hr
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00029437:dcr-1_downregulated
      WBPaper00031703:heme_responsive_4
      WBPaper00031850:mdt-15(RNAi)_upregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:FedUp
      WBPaper00035873:dpy-10_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037147:heatshock_downregulated
      WBPaper00037695:WC_5-day
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00038427:lin-54_germline_changed
      WBPaper00038462:aging_downregulated
      WBPaper00039851:HK_C_albicans_vs_HK_OP50
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2nc
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q200_up
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041211:RPW-24_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_10d
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045374:Benzene_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00049311:AgNO3_regulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053688:E.faecalis_downregulated
      WBPaper00053688:E.faecium_downregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
    Interaction (47)
  Map_info: Map: X Position: -1.77366
    Positive: Positive_clone: T08A9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00003435
    WBPaper00006437
    WBPaper00024209
    WBPaper00035289
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene