WormBase Tree Display for Gene: WBGene00004932
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| WBGene00004932 | SMap | S_parent | Sequence | C08A9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sod-3 | |||||||
| Sequence_name | C08A9.1 | ||||||||
| Molecular_name | C08A9.1 | ||||||||
| C08A9.1.1 | |||||||||
| CE08002 | |||||||||
| Other_name | MnSOD | Accession_evidence | EMBL | X77021 | |||||
| CELE_C08A9.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | sod-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sod | ||||||||
| Reference_allele | |||||||||
| Allele (23) | |||||||||
| Legacy_information | [C.elegansII] NMK. Cloned: encodes manganese superoxide dismutase,227 aa. [Giglio et al. 1994a] | ||||||||
| Strain (17) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (20) | |||||||||
| Paralog | WBGene00004931 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-3 mRNA levels are diminished by mutation of daf-16 and chromatin immunoprecipitation (ChIP) studies demonstrate that DAF-16 can directly bind the sod-3 promoter; heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress. | Paper_evidence | WBPaper00002936 | |||||
| WBPaper00004424 | |||||||||
| WBPaper00005647 | |||||||||
| WBPaper00027009 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 Apr 2008 00:00:00 | ||||||||
| Automated_description | Enables protein homodimerization activity and superoxide dismutase activity. Involved in removal of superoxide radicals. Located in mitochondrial respirasome. Expressed in several structures, including head; intestine; pharynx; tail; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autoimmune disease (multiple); and hematologic cancer (multiple). Is an ortholog of human SOD2 (superoxide dismutase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (45) | ||||||||
| Molecular_info | Corresponding_CDS | C08A9.1 | |||||||
| Corresponding_transcript | C08A9.1.1 | ||||||||
| Other_sequence (22) | |||||||||
| Associated_feature | WBsf019138 | ||||||||
| WBsf979053 | |||||||||
| WBsf1008798 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (24) | |||||||||
| Construct_product | WBCnstr00005185 | ||||||||
| WBCnstr00005186 | |||||||||
| WBCnstr00008238 | |||||||||
| WBCnstr00013143 | |||||||||
| WBCnstr00019246 | |||||||||
| WBCnstr00035313 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (279) | |||||||||
| Interaction (446) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000096 | |||||||||
| Map_info | Map | X | Position | 24.0747 | Error | 0.001675 | |||
| Positive | Positive_clone | C08A9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4685 | |||||||
| Pseudo_map_position | |||||||||
| Reference (446) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
