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WormBase Tree Display for Gene: WBGene00004347

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Name Class

WBGene00004347SMapS_parentSequenceY38E10A
IdentityVersion3
NameCGC_namergs-4Person_evidenceWBPerson330
Sequence_nameY38E10A.21
Molecular_name (12)
Other_nameCELE_Y38E10A.21Accession_evidenceNDBBX284602
Public_namergs-4
DB_infoDatabaseAceViewgene2M957
WormQTLgeneWBGene00004347
WormFluxgeneWBGene00004347
NDBlocus_tagCELE_Y38E10A.21
PanthergeneCAEEL|WormBase=WBGene00004347|UniProtKB=H2KMK7
familyPTHR10845
NCBIgene189666
RefSeqproteinNM_001381631.1
NM_001377886.2
NM_001267421.4
NM_001373807.2
TrEMBLUniProtAccH2KMK5
A0A5S9MNH1
A0A486WXG8
H2KMK7
UniProt_GCRPUniProtAccA0A5S9MNH1
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:35WBPerson1971EventImportedInitial conversion from geneace
203 Dec 2004 16:28:54WBPerson2970EventAcquires_mergeWBGene00012599
321 Nov 2019 16:12:41WBPerson4025EventAcquires_mergeWBGene00012598
Acquires_mergeWBGene00012599
WBGene00012598
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classrgs
Allele (540)
StrainWBStrain00026366
WBStrain00031678
RNASeq_FPKM (74)
Ortholog (31)
Paralog (12)
Structured_descriptionConcise_descriptionrgs-4 encodes a regulator of G protein signaling; by homology, RGS-4 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-4 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-4 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; the RGS-4 expression pattern has not yet been reported.Paper_evidenceWBPaper00004281
WBPaper00024480
Curator_confirmedWBPerson1843
Date_last_updated07 Feb 2005 00:00:00
Automated_descriptionEnriched in head mesodermal cell; neurons; and ventral nerve cord based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; glp-1; and eat-2 based on tiling array; microarray; and RNA-seq studies. Is affected by thirteen chemicals including stavudine; Psoralens; and allantoin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: RGS domain; RGS domain superfamily; Regulator of G protein signaling domain; and RGS, subdomain 2.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSY38E10A.21a
Y38E10A.21b
Y38E10A.21c
Y38E10A.21d
Corresponding_CDS_historyY38E10A.21:wp229
Y38E10A.21a:wp274
Corresponding_transcriptY38E10A.21a.1
Y38E10A.21b.1
Y38E10A.21c.1
Y38E10A.21d.1
Other_sequence (36)
Associated_feature (12)
Experimental_infoRNAi_resultWBRNAi00020288Inferred_automaticallyRNAi_primary
WBRNAi00056020Inferred_automaticallyRNAi_primary
WBRNAi00020287Inferred_automaticallyRNAi_primary
WBRNAi00056021Inferred_automaticallyRNAi_primary
Expr_patternChronogram882
Chronogram1470
Expr1022441
Expr1027927
Expr1032165
Expr1159539
Expr1159540
Expr2007301
Expr2015327
Expr2033561
Drives_constructWBCnstr00004337
Microarray_results (35)
Expression_clusterWBPaper00032031:DConiospora_upregulated_OligoArray_24h
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:dopaminergic-neurons_larva_enriched
WBPaper00037950:GABAergic-motor-neurons_CoreEnriched
WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_larva_enriched
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_larva_enriched
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_larva_enriched
WBPaper00038168:lin-35_upregulated
WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00044037:eat-2_upregulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_upregulated_L2
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049001:EVN_enriched
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053664:ins-11(tm1053)_downregulated
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Psora_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin-Psora_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055565:AVK_enriched
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056330:glycine_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056826:hmc_biased
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00059027:neuron-synapses_depleted
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060445:nfki-1(cer1)_downregulated_L4
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:sre-33-ZK1025.1_8337
WBPaper00061527:tub-2_4713-daf-2_5288
WBPaper00061651:I4_enriched
WBPaper00061753:csr-1(tor159)_upregulated_25C
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065841:6_1
WBPaper00065841:125_0
WBPaper00065841:131_0
WBPaper00065841:138_0
WBPaper00065841:139_0
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4489_group_14
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00036123:Atrazine_regulated
WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
WBPaper00045294:0.1uM_DBAA_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:N2_allantoin_upregulated
Map_infoMapIIPosition10.6551Error0.037636
PositivePositive_cloneY38E10AInferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4624
4673
5028
Pseudo_map_position
ReferenceWBPaper00004281
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene