| WBGene00004134 | SMap | S_parent | Sequence | CHROMOSOME_II |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | myrf-1 | Person_evidence | WBPerson7150 |
| | | Sequence_name | F59B10.1 |
| | | Molecular_name | F59B10.1 |
| | | | F59B10.1.1 |
| | | | CE36940 |
| | | Other_name | pqn-47 | Person_evidence | WBPerson625 |
| | | | CELE_F59B10.1 | Accession_evidence | NDB | BX284602 |
| | | Public_name | myrf-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change (2) |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | myrf |
| | Allele (84) |
| | Possibly_affected_by | WBVar02157207 |
| | Strain | WBStrain00037532 |
| | | WBStrain00037768 |
| | RNASeq_FPKM (74) |
| | GO_annotation (32) |
| | Ortholog (43) |
| | Paralog | WBGene00008999 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | myrf-1 encodes a protein with a glutamine/asparagine-rich domain, orthologous to human MYRF (myelin regulatory factor); in C. elegans, MYRF-1 activity is required for regulation of the molting cycle, specifically the completion of larval molts and cessation of molting in reproductively mature adult animals; a MYRF-1::GFP fusion protein is expressed in a wide variety of cells and tissues, including neurons, secretory cells, and hypodermal seam cells, but is not seen in the hyp7 syncytial hypodermis; expression begins in the comma stage of embryogenesis and persists through adulthood; full length C. elegans MYRF-1::GFP localizes to the cytoplasm where it partially overlaps with the endoplasmic reticulum; MYRF-1 contains a well-conserved paralog in the C. elegans genome, MYRF-2, encoded by F21A10.2. | Paper_evidence | WBPaper00004651 |
| | | | | | WBPaper00005487 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00012811 |
| | | | | | WBPaper00040293 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 19 Dec 2014 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in ecdysis, collagen and cuticulin-based cuticle and nematode larval development. Located in basal part of cell and endoplasmic reticulum. Expressed in several structures, including ciliated neurons; excretory duct; gonad; pharyngeal cell; and somatic nervous system. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; and eye disease (multiple). Is an ortholog of human MYRFL (myelin regulatory factor like). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0080634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) |
| | | DOID:3827 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) |
| | | DOID:9834 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) |
| | | DOID:1405 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) |
| | | DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) |
| Molecular_info | Corresponding_CDS | F59B10.1 |
| | Corresponding_CDS_history | F59B10.1:wp127 |
| | Corresponding_transcript | F59B10.1.1 |
| | Other_sequence | CR10282 |
| | | CR10281 |
| | | CRC03559_1 |
| | | ACC07624_1 |
| | | SRC00534_1 |
| | | EY470006.1 |
| | | Tcol_isotig21011 |
| | | SR01712 |
| | | Name_isotig07910 |
| | | JI164614.1 |
| | Associated_feature (15) |
| | Transcription_factor | WBTranscriptionFactor000563 |
| Experimental_info | RNAi_result (46) |
| | Expr_pattern (14) |
| | Drives_construct | WBCnstr00004111 |
| | | WBCnstr00009459 |
| | | WBCnstr00009460 |
| | | WBCnstr00014243 |
| | | WBCnstr00014244 |
| | | WBCnstr00019909 |
| | | WBCnstr00037934 |
| | Construct_product | WBCnstr00009460 |
| | | WBCnstr00014243 |
| | | WBCnstr00014244 |
| | | WBCnstr00037934 |
| | Regulate_expr_cluster | WBPaper00061377:MYRF-1_interacting |
| | Microarray_results (16) |
| | Expression_cluster | WBPaper00032528:L3_enriched |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00041222:unc-120(st364)_downregulated |
| | | WBPaper00043945:MeHg_upregulated |
| | | WBPaper00044037:eat-2_downregulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044760:somatic_specific |
| | | WBPaper00045316:prg-1_upregulated_L2 |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated |
| | | WBPaper00046337:polysomal_N2_vs_daf-2_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048611:MnCl2_upregulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049001:EVN_enriched |
| | | WBPaper00049018:swsn-2.2(RNAi)_downregulated |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050903:mir-35-41(nDf50)_25C_upregulated |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00055013:hmg-3(bar24)_downregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056169:rrf-3(pk1426)_downregulated_L4 |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L1 |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056290:mdt-15(mg584)_upregulated |
| | | WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated |
| | | WBPaper00056330:glycine_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00057347:nhr-14(tm1473)_downreglated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059334:sacy-1(depletion)_regulated |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060434:pH4.33_vs_pH6.33_downrgulated |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:Neuroblast_AIZ_FLP |
| | | WBPaper00061340:Neuroblast_HSN_PHB |
| | | WBPaper00061340:NSM_parent |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:MYRF-2_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061527:col-128-cdh-10_9234 |
| | | WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:MC_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_AFD |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062534:fat-P-80_downregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064494:postdauer_upregulated_AWA |
| | | WBPaper00064532:pals-25(icb98)_downregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065746:eat-2(ad1113)_downregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065984:pals-17(syb3980)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_4_6 |
| | | cgc4489_group_3 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00033101:spr-5_regulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00037611:GLD-2-associated |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00047070:N2_UV_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc6390]:Cluster_B |
| | Interaction (679) |
| | Anatomy_function | WBbtf1093 |
| | | WBbtf1094 |
| | | WBbtf1095 |
| Map_info | Map | II | Position | 2.9838 | Error | 0.041984 |
| | Positive | Positive_clone | F59B10 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (14) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
