WormBase Tree Display for Gene: WBGene00004008

WBGene00004008 SMap: S_parent: Sequence: F22E10
  Identity: Version: 1
    Name: CGC_name: pgp-14 Person_evidence: WBPerson490
      Sequence_name: F22E10.3
      Molecular_name: F22E10.3
        F22E10.3.1
        CE03262
      Other_name: CELE_F22E10.3 Accession_evidence: NDB BX284606
      Public_name: pgp-14
    DB_info: Database: AceView gene XN364
        WormQTL gene WBGene00004008
        WormFlux gene WBGene00004008
        NDB locus_tag CELE_F22E10.3
        Panther gene CAEEL|WormBase=WBGene00004008|UniProtKB=G5EG61
          family PTHR24221
        NCBI gene 181416
        RefSeq protein NM_077727.10
        TrEMBL UniProtAcc G5EG61
        UniProt_GCRP UniProtAcc G5EG61
        OMIM gene 171050
            171060
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pgp
    Allele (62)
    Strain: WBStrain00001996
      WBStrain00032692
    RNASeq_FPKM (74)
    GO_annotation (13)
    Contained_in_operon: CEOPX110
    Ortholog (53)
    Paralog (24)
    Structured_description: Concise_description: pgp-14 encodes a member of the ABC transporter family with high similarity to the vertebrate MDR (multidrug resistance) family; PGP-14 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-14 activity via large-scale RNAi screens does not result in any obvious defects, the precise role of pgp-14 in C. elegans development and/or behavior is not yet known; pgp-14 promoter-gfp fusion proteins are expressed in larvae and adults in the anterior pharynx. Paper_evidence: WBPaper00006421
            WBPaper00006525
            WBPaper00024561
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 07 Mar 2006 00:00:00
      Automated_description: Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in response to nematicide. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (39)
  Molecular_info: Corresponding_CDS: F22E10.3
    Corresponding_transcript: F22E10.3.1
    Other_sequence: JI168113.1
      JI235600.1
      JI231282.1
      JI164894.1
      Acan_isotig21429
      JI218053.1
      CJC02657_1
      ASC19568_1
      JI241304.1
    Associated_feature: WBsf238081
      WBsf238082
      WBsf238083
  Experimental_info: RNAi_result: WBRNAi00045324 Inferred_automatically: RNAi_primary
      WBRNAi00000347 Inferred_automatically: RNAi_primary
      WBRNAi00077361 Inferred_automatically: RNAi_primary
      WBRNAi00013753 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3326
      Expr3327
      Expr4618
      Expr5828
      Expr1031917
      Expr1149248
      Expr2014867
      Expr2033102
    Drives_construct: WBCnstr00002780
      WBCnstr00011322
      WBCnstr00011323
      WBCnstr00012122
      WBCnstr00035743
    Construct_product: WBCnstr00035743
    Microarray_results (16)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032976:dosage_compensated_genes
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00040285:H2S_12hr_downregulated
      WBPaper00040285:H2S_24hr_downregulated
      WBPaper00040560:hpl-2_L3_downregulated
      WBPaper00042165:let-7_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00043945:MeHg_downregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00044857:BAR-1_downregulated
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046415:lithium_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049954:BPA_upregulated
      WBPaper00050332:juglone_upregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050561:indole_0.1mM-indole_upregulated
      WBPaper00050561:indole_10-fold_upregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_enriched
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_specific
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053664:ins-11(tm1053)_downregulated
      WBPaper00053771:down_by_skn-1(RNAi)_at_dpy-7(e88)
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00054410:set-9(rw5)_upregulated
      WBPaper00054410:set-26(tm2467)_upregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055013:spt-16(RNAi)_upregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora_upregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:anterior-head_expressed
      WBPaper00055648:pharynx_expressed
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056039:hda-6(ok3203)_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_L4
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:numr-1(RNAi)_upregulated
      WBPaper00057143:ztf-11(RNAi)_upregulated
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_upregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058665:graphene-oxide_upregulated_mRNA
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059191:hsp-16.2p-LIN-29_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060445:ikb-1(nr2027)_upregulated_L1
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061340:Arcade_cell_anterior_and_posterior
      WBPaper00061340:g2
      WBPaper00061340:MC
      WBPaper00061340:pm8
      WBPaper00061340:PVP
      WBPaper00061357:mett-10(ok2204)_upregulated_OP50
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:tnt-4-myo-1_2160
      WBPaper00061651:NSM_enriched
      WBPaper00061853:osm-3(dh441)_downregulated_tunicamycin
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064788:ketamine_upregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065272:dhgd-1(tm6671)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065823:pmk-1(km25)_upregulated
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:9_0
      WBPaper00065841:9_1
      WBPaper00065841:9_2
      WBPaper00065841:15_0
      WBPaper00065841:24_0
      WBPaper00065841:24_1
      WBPaper00065841:27_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066118:cyclobutrifluram_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4489_group_20
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:FedUp
      WBPaper00034661:AgNPs_downregulated
      WBPaper00034739:N2moreDR1350
      WBPaper00034739:RIL17moreRIL14
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_C
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00040821:Au-NP_regulated
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041267:SpaceFlight_Downregulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_downregulated_YoungAdult
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045865:biofilm_downregulated_B
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00049311:AgNO3_regulated
      WBPaper00050650:mBmkTX_downregulated
      WBPaper00051387:Triclosan_upregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc6390]:Cluster_C
    Interaction (33)
  Map_info: Map: X Position: 8.21375 Error: 0.008856
    Positive: Positive_clone: F22E10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Sequence connection from [Sheps JA, Baillie DL] [040902 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene