WormBase Tree Display for Gene: WBGene00003970
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| WBGene00003970 | Evidence | Paper_evidence | WBPaper00005044 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_X | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | pek-1 | Person_evidence | WBPerson159 | |||||
| Sequence_name | F46C3.1 | ||||||||
| Molecular_name | F46C3.1 | ||||||||
| F46C3.1.1 | |||||||||
| CE18695 | |||||||||
| Other_name | perk | Accession_evidence | EMBL | AF435953 | |||||
| CELE_F46C3.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | pek-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pek | ||||||||
| Allele (59) | |||||||||
| Strain | WBStrain00031350 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (40) | |||||||||
| Ortholog (76) | |||||||||
| Paralog | WBGene00006988 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00006940 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006938 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00013591 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00012586 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | pek-1 encodes a predicted transmembrane protein kinase orthologous to human eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3, OMIM:604032), which when mutated leads to Wolcott-Rallison syndrome; PEK-1 is strongly expressed in intestinal cells and is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); PEK-1 may function in the endoplasmic reticulum to phosphorylate eIF2alpha and inhibit protein synthesis in response to endogenous ER stress. | Paper_evidence | WBPaper00005044 | |||||
| WBPaper00012770 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables eukaryotic translation initiation factor 2alpha kinase activity. Involved in several processes, including PERK-mediated unfolded protein response; nematode larval development; and positive regulation of protein phosphorylation. Predicted to be located in endoplasmic reticulum membrane and nucleus. Expressed in intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Is an ortholog of human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3255) | ||||
| DOID:0090060 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3255) | ||||||
| Molecular_info | Corresponding_CDS | F46C3.1 | |||||||
| Corresponding_transcript | F46C3.1.1 | ||||||||
| Other_sequence (11) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern | Expr11238 | ||||||||
| Expr1021883 | |||||||||
| Expr1031894 | |||||||||
| Expr1151339 | |||||||||
| Expr2014818 | |||||||||
| Expr2033052 | |||||||||
| Drives_construct | WBCnstr00018515 | ||||||||
| WBCnstr00035765 | |||||||||
| Construct_product | WBCnstr00035765 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction (67) | |||||||||
| Anatomy_function | WBbtf1106 | ||||||||
| WBProcess | WBbiopr:00000030 | ||||||||
| WBbiopr:00000046 | |||||||||
| WBbiopr:00000050 | |||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | X | Position | 3.65577 | Error | 0.049696 | |||
| Positive | Positive_clone | F46C3 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4427 | |||||||
| 4569 | |||||||||
| 4663 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (73) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
