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WormBase Tree Display for Gene: WBGene00003970

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Name Class

WBGene00003970EvidencePaper_evidenceWBPaper00005044
SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namepek-1Person_evidenceWBPerson159
Sequence_nameF46C3.1
Molecular_nameF46C3.1
F46C3.1.1
CE18695
Other_nameperkAccession_evidenceEMBLAF435953
CELE_F46C3.1Accession_evidenceNDBBX284606
Public_namepek-1
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpek
Allele (59)
StrainWBStrain00031350
RNASeq_FPKM (74)
GO_annotation (40)
Ortholog (76)
ParalogWBGene00006988Caenorhabditis elegansFrom_analysisPanther
WBGene00006940Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006938Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00013591Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00012586Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionpek-1 encodes a predicted transmembrane protein kinase orthologous to human eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3, OMIM:604032), which when mutated leads to Wolcott-Rallison syndrome; PEK-1 is strongly expressed in intestinal cells and is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); PEK-1 may function in the endoplasmic reticulum to phosphorylate eIF2alpha and inhibit protein synthesis in response to endogenous ER stress.Paper_evidenceWBPaper00005044
WBPaper00012770
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables eukaryotic translation initiation factor 2alpha kinase activity. Involved in several processes, including PERK-mediated unfolded protein response; nematode larval development; and positive regulation of protein phosphorylation. Predicted to be located in endoplasmic reticulum membrane and nucleus. Expressed in intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Is an ortholog of human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:9744Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3255)
DOID:0090060Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3255)
Molecular_infoCorresponding_CDSF46C3.1
Corresponding_transcriptF46C3.1.1
Other_sequence (11)
Associated_feature (12)
Experimental_infoRNAi_result (22)
Expr_patternExpr11238
Expr1021883
Expr1031894
Expr1151339
Expr2014818
Expr2033052
Drives_constructWBCnstr00018515
WBCnstr00035765
Construct_productWBCnstr00035765
Microarray_results (21)
Expression_cluster (141)
InteractionWBInteraction000004960
WBInteraction000009184
WBInteraction000009185
WBInteraction000009186
WBInteraction000009187
WBInteraction000009189
WBInteraction000029618
WBInteraction000030929
WBInteraction000052842
WBInteraction000052961
WBInteraction000136898
WBInteraction000138040
WBInteraction000198573
WBInteraction000241712
WBInteraction000253137
WBInteraction000294160
WBInteraction000294161
WBInteraction000294162
WBInteraction000297972
WBInteraction000309193
WBInteraction000389847
WBInteraction000403390
WBInteraction000472433
WBInteraction000501559
WBInteraction000520461
WBInteraction000520462
WBInteraction000520495
WBInteraction000520612
WBInteraction000520613
WBInteraction000520654
WBInteraction000520655
WBInteraction000520698
WBInteraction000520700
WBInteraction000520701
WBInteraction000520704
WBInteraction000536194
WBInteraction000536198
WBInteraction000536199
WBInteraction000536200
WBInteraction000536201
WBInteraction000536202
WBInteraction000536203
WBInteraction000536402
WBInteraction000536415
WBInteraction000536418
WBInteraction000536434
WBInteraction000536438
WBInteraction000536439
WBInteraction000536440
WBInteraction000536441
WBInteraction000536535
WBInteraction000536536
WBInteraction000536736
WBInteraction000536737
WBInteraction000536738
WBInteraction000536739
WBInteraction000536740
WBInteraction000536741
WBInteraction000536742
WBInteraction000536743
WBInteraction000536744
WBInteraction000536745
WBInteraction000536746
WBInteraction000536761
WBInteraction000536762
WBInteraction000536763
WBInteraction000536842
Anatomy_functionWBbtf1106
WBProcessWBbiopr:00000030
WBbiopr:00000046
WBbiopr:00000050
WBbiopr:00000079
Map_infoMapXPosition3.65577Error0.049696
PositivePositive_cloneF46C3Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4427
4569
4663
Pseudo_map_position
Reference (73)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene