WormBase Tree Display for Gene: WBGene00003970
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WBGene00003970 | Evidence | Paper_evidence | WBPaper00005044 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_X | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | pek-1 | Person_evidence | WBPerson159 | |||||
Sequence_name | F46C3.1 | ||||||||
Molecular_name | F46C3.1 | ||||||||
F46C3.1.1 | |||||||||
CE18695 | |||||||||
Other_name | perk | Accession_evidence | EMBL | AF435953 | |||||
CELE_F46C3.1 | Accession_evidence | NDB | BX284606 | ||||||
Public_name | pek-1 | ||||||||
DB_info | Database (14) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | pek | ||||||||
Allele (59) | |||||||||
Strain | WBStrain00031350 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (40) | |||||||||
Ortholog (76) | |||||||||
Paralog | WBGene00006988 | Caenorhabditis elegans | From_analysis | Panther | |||||
WBGene00006940 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00006938 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00013591 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00012586 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | pek-1 encodes a predicted transmembrane protein kinase orthologous to human eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3, OMIM:604032), which when mutated leads to Wolcott-Rallison syndrome; PEK-1 is strongly expressed in intestinal cells and is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); PEK-1 may function in the endoplasmic reticulum to phosphorylate eIF2alpha and inhibit protein synthesis in response to endogenous ER stress. | Paper_evidence | WBPaper00005044 | |||||
WBPaper00012770 | |||||||||
Curator_confirmed (3) | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables eukaryotic translation initiation factor 2alpha kinase activity. Involved in several processes, including PERK-mediated unfolded protein response; nematode larval development; and positive regulation of protein phosphorylation. Predicted to be located in endoplasmic reticulum membrane and nucleus. Expressed in intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Is an ortholog of human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed (2) | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3255) | ||||
DOID:0090060 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3255) | ||||||
Molecular_info | Corresponding_CDS | F46C3.1 | |||||||
Corresponding_transcript | F46C3.1.1 | ||||||||
Other_sequence (11) | |||||||||
Associated_feature (12) | |||||||||
Experimental_info | RNAi_result (22) | ||||||||
Expr_pattern | Expr11238 | ||||||||
Expr1021883 | |||||||||
Expr1031894 | |||||||||
Expr1151339 | |||||||||
Expr2014818 | |||||||||
Expr2033052 | |||||||||
Drives_construct | WBCnstr00018515 | ||||||||
WBCnstr00035765 | |||||||||
Construct_product | WBCnstr00035765 | ||||||||
Microarray_results (21) | |||||||||
Expression_cluster (141) | |||||||||
Interaction (67) | |||||||||
Anatomy_function | WBbtf1106 | ||||||||
WBProcess | WBbiopr:00000030 | ||||||||
WBbiopr:00000046 | |||||||||
WBbiopr:00000050 | |||||||||
WBbiopr:00000079 | |||||||||
Map_info | Map | X | Position | 3.65577 | Error | 0.049696 | |||
Positive | Positive_clone | F46C3 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | Multi_point | 4427 | |||||||
4569 | |||||||||
4663 | |||||||||
Pseudo_map_position | |||||||||
Reference (73) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |