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WormBase Tree Display for Gene: WBGene00003970

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Name Class

WBGene00003970EvidencePaper_evidenceWBPaper00005044
SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namepek-1Person_evidenceWBPerson159
Sequence_nameF46C3.1
Molecular_nameF46C3.1
F46C3.1.1
CE18695
Other_nameperkAccession_evidenceEMBLAF435953
CELE_F46C3.1Accession_evidenceNDBBX284606
Public_namepek-1
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpek
Allele (59)
StrainWBStrain00031350
RNASeq_FPKM (74)
GO_annotation (40)
OrthologWBGene00058289Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00036993Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00148328Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00110200Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WBGene00136645Caenorhabditis japonicaFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00224397Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g3925Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g13982Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g11926Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g18774Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g15819Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP38.g11210Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g28779Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g12619Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00066.g3212Caenorhabditis angariaFrom_analysisWormBase-Compara
Cnig_chr_X.g23187Caenorhabditis nigoniFrom_analysisWormBase-Compara
Cnig_chr_X.g23188Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold49.g284Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00026.g1532Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_01122Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_023789Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g00407Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g12770Panagrellus redivivusFrom_analysisWormBase-Compara
chrX_pilon.g20068Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00241214Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00091010Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00094636Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00094637Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00102486Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00102859Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00104016Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00104292Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00105219Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00105699Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00110564Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00110684Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00110714Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00110738Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00110739Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00110761Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00272074Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00272076Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274110Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274520Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274625Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274632Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274746Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274755Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274760Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274768Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274769Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274770Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274773Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274774Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274777Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274779Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274788Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274792Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274858Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274872Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274881Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274921Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00276231Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00276465Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00276473Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00279438Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00281382Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00282590Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00264691Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00288722Trichuris murisFrom_analysisWormBase-Compara
SGD:S000003593Saccharomyces cerevisiaeFrom_analysisEnsEMBL-Compara
Panther
FB:FBgn0037327Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-050414-2Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
HGNC:3255Homo sapiensFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
MGI:1341830Mus musculusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
Panther
PhylomeDB
SonicParanoid
RGD:70884Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
Panther
SonicParanoid
ParalogWBGene00006988Caenorhabditis elegansFrom_analysisPanther
WBGene00006940Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006938Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00013591Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00012586Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionpek-1 encodes a predicted transmembrane protein kinase orthologous to human eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3, OMIM:604032), which when mutated leads to Wolcott-Rallison syndrome; PEK-1 is strongly expressed in intestinal cells and is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); PEK-1 may function in the endoplasmic reticulum to phosphorylate eIF2alpha and inhibit protein synthesis in response to endogenous ER stress.Paper_evidenceWBPaper00005044
WBPaper00012770
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables eukaryotic translation initiation factor 2alpha kinase activity. Involved in several processes, including PERK-mediated unfolded protein response; nematode larval development; and positive regulation of protein phosphorylation. Predicted to be located in endoplasmic reticulum membrane and nucleus. Expressed in intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Is an ortholog of human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:9744Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3255)
DOID:0090060Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3255)
Molecular_infoCorresponding_CDSF46C3.1
Corresponding_transcriptF46C3.1.1
Other_sequence (11)
Associated_feature (12)
Experimental_infoRNAi_result (22)
Expr_patternExpr11238
Expr1021883
Expr1031894
Expr1151339
Expr2014818
Expr2033052
Drives_constructWBCnstr00018515
WBCnstr00035765
Construct_productWBCnstr00035765
Microarray_results (21)
Expression_cluster (141)
Interaction (67)
Anatomy_functionWBbtf1106
WBProcessWBbiopr:00000030
WBbiopr:00000046
WBbiopr:00000050
WBbiopr:00000079
Map_infoMapXPosition3.65577Error0.049696
PositivePositive_cloneF46C3Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4427
4569
4663
Pseudo_map_position
Reference (73)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene