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WormBase Tree Display for Gene: WBGene00003408

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Name Class

WBGene00003408SMapS_parentSequenceF57C12
IdentityVersion1
NameCGC_namemrp-2Person_evidenceWBPerson490
Sequence_nameF57C12.4
Molecular_nameF57C12.4
F57C12.4.1
CE26370
Other_nameCELE_F57C12.4Accession_evidenceNDBBX284606
Public_namemrp-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:31WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmrp
AlleleWBVar00239249
WBVar01710536
WBVar02048373
WBVar01823953
WBVar01823954
WBVar01618291
WBVar00074344
WBVar00074345
WBVar01498638
WBVar01113654
WBVar01979021
WBVar01113655
WBVar01979022
WBVar01113656
WBVar01113657
WBVar01113658
WBVar01113659
WBVar01113660
WBVar01113661
WBVar01113662
WBVar01113663
WBVar01113664
WBVar01113665
WBVar01113666
WBVar02049159
WBVar01113667
WBVar01467314
WBVar01113668
WBVar01113669
WBVar01113670
WBVar01113671
WBVar01113672
WBVar01113673
WBVar01113674
WBVar01113675
WBVar01113676
WBVar00276751
WBVar01113677
WBVar00276752
WBVar01113678
WBVar01113679
WBVar01113680
WBVar01486158
WBVar01113681
WBVar01113682
WBVar01113683
WBVar01113684
WBVar01113685
WBVar01113686
WBVar01113687
WBVar01639581
WBVar01113688
WBVar01113689
WBVar02008971
WBVar01113690
WBVar01113691
WBVar01113692
WBVar00256791
WBVar01113693
WBVar01113694
WBVar02138578
WBVar02138579
WBVar01113695
WBVar00492598
WBVar01113696
WBVar00492599
WBVar01113697
WBVar00492600
WBVar01113698
WBVar00492601
WBVar01113699
WBVar00492602
WBVar01113700
WBVar00492603
WBVar01113701
WBVar01113702
WBVar00492604
WBVar01113703
WBVar00492605
WBVar01113704
WBVar00492606
WBVar01113705
WBVar00492607
WBVar00492608
WBVar01113706
WBVar00492609
WBVar01113707
WBVar00599045
WBVar00492610
WBVar01113708
WBVar01113709
WBVar00492611
WBVar00492612
WBVar01113710
WBVar01113711
WBVar00492613
WBVar01113712
WBVar00492614
WBVar01113713
WBVar00093332
WBVar00492615
WBVar01113714
WBVar00492616
WBVar00492617
WBVar01113715
WBVar00492618
WBVar01113716
WBVar00492619
WBVar01113717
WBVar00492620
WBVar01113718
WBVar01113719
WBVar00492621
WBVar01113720
WBVar01113721
WBVar01113722
WBVar01113723
WBVar01499636
WBVar02039026
WBVar01600320
WBVar01600321
WBVar01600322
WBVar01600323
WBVar01986932
WBVar00603793
WBVar02050387
WBVar01914178
Legacy_information[C.elegansII] NMK. Encodes predicted protein similar to human MRP. [NL]
mrp for Multidrug Resistance-associated Protein family. mrp-2 is F57C12.4, encodes 1475aa protein, 48% identical to human MRP1. No mutants known.
StrainWBStrain00032405
RNASeq_FPKM (74)
GO_annotation (13)
Contained_in_operonCEOPX154
Ortholog (49)
ParalogWBGene00000477Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003407Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00003411Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003410Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003409Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003414Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003413Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003412Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionmrp-2 encodes a predicted multidomain transmembrane protein that is a member of the ATP-binding cassette (ABC) superfamily of transport proteins and is homologous to the human multidrug resistance-associated protein 1 (MRP1, OMIM:158343); by homology, MRP-2 is predicted to function as a membrane pump that couples the energy of ATP hydrolysis to membrane transport; as loss of MRP-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of MRP-2 in C. elegans development and/or behavior is not yet known; mrp-2 expression is, however, upregulated early in the exit from the alternative dauer stage and then remains induced, suggesting that MRP-2 activity is required for the transition to, and maintenance of, a more active metabolic state.Paper_evidenceWBPaper00002619
WBPaper00004424
WBPaper00005859
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including bile duct disease (multiple); leukemia (multiple); and lung disease (multiple). Is an ortholog of human ABCC3 (ATP binding cassette subfamily C member 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (13)
Molecular_infoCorresponding_CDSF57C12.4
Corresponding_transcriptF57C12.4.1
Other_sequence (28)
Associated_featureWBsf034317
WBsf670064
WBsf1003807
WBsf1003808
WBsf1022144
WBsf1022145
WBsf236931
Experimental_infoRNAi_resultWBRNAi00097976Inferred_automaticallyRNAi_primary
WBRNAi00048850Inferred_automaticallyRNAi_primary
WBRNAi00015883Inferred_automaticallyRNAi_primary
Expr_patternChronogram310
Expr6241
Expr1012747
Expr1031577
Expr1152599
Expr2013687
Expr2031922
Drives_constructWBCnstr00002777
Microarray_results (21)
Expression_cluster (186)
Interaction (48)
Map_infoMapXPosition-19.6347Error0.009197
PositivePositive_cloneF57C12Person_evidenceWBPerson4545
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (15)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene