WormBase Tree Display for Gene: WBGene00003239
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WBGene00003239 | SMap | S_parent | Sequence | C35C5 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | mig | |||||
Allele (39) | ||||||
Legacy_information | rh17 : variable abnormal migration of Q neuroblasts HSN cells CAN cells. | |||||
[C.elegansII] rh17 : variable abnormal migration of Q neuroblasts, HSN cells, CAN cells etc.; Egl; uncoordinated; axon defects. OA1. [Hedgecock et al. 1987; Desai et al. 1988; NJ] | ||||||
[Zipkin ID, Kindt RM, Kenyon CJ] mu28 homozygotes exhibit abnormal migration of Q daughters. Predicted gene C35C5.4, encodes Rho-related protein. | ||||||
Strain | WBStrain00024138 | |||||
WBStrain00024141 | ||||||
WBStrain00024146 | ||||||
WBStrain00024159 | ||||||
WBStrain00024170 | ||||||
WBStrain00024172 | ||||||
WBStrain00028737 | ||||||
WBStrain00028748 | ||||||
WBStrain00032460 | ||||||
WBStrain00004808 | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (56) | ||||||
Ortholog (39) | ||||||
Paralog | WBGene00000390 | Caenorhabditis elegans | From_analysis | Panther | ||
WormBase-Compara | ||||||
WBGene00000424 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | ||||||
WBGene00004357 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | ||||||
WBGene00004287 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | ||||||
WormBase-Compara | ||||||
WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther | |||
WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | ||||||
WBGene00012532 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | ||||||
WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | ||||||
Structured_description | Concise_description | mig-2 encodes a member of the RhoG family of GTP-binding proteins; MIG-2 activity is required for migration of Q neuroblasts, HSN neurons, and CAN cells as well as neurite outgrowth and guidance; in regulating Q neuroblast migration and dendrite outgrowth, MIG-2 functions upstream of the ANI-1 anillin to asymmetrically regulate ANI-1 localization, and thus stabilize F-actin, at the leading edge and growth cone; MIG-2 is expressed in early embryos and in adults in the vulva, gonadal distal tip cells, and the sex myoblasts and their descendants. | Paper_evidence | WBPaper00046615 | ||
WBPaper00002878 | ||||||
Curator_confirmed | WBPerson48 | |||||
WBPerson1843 | ||||||
WBPerson567 | ||||||
Date_last_updated | 28 May 2015 00:00:00 | |||||
Automated_description | Enables GTPase activity and protein kinase binding activity. Involved in several processes, including actin cytoskeleton organization; axon guidance; and cell migration. Located in cytoplasm; cytoplasmic side of plasma membrane; and neuron projection. Expressed in several structures, including CAN; HSN; distal tip cell; touch receptor neurons; and vulval cell. Used to study epilepsy. Is an ortholog of human RHOG (ras homolog family member G). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | |
Curator_confirmed | WBPerson38202 | |||||
Date_last_updated | 04 Jun 2018 00:00:00 | |||||
Models_disease_asserted | WBDOannot00000557 | |||||
Molecular_info | Corresponding_CDS | C35C5.4a | ||||
C35C5.4b | ||||||
Corresponding_transcript | C35C5.4a.1 | |||||
C35C5.4b.1 | ||||||
Other_sequence (25) | ||||||
Associated_feature | WBsf663364 | |||||
WBsf1007033 | ||||||
WBsf1007034 | ||||||
WBsf1007035 | ||||||
WBsf236390 | ||||||
WBsf236391 | ||||||
WBsf236392 | ||||||
WBsf236393 | ||||||
WBsf236394 | ||||||
Experimental_info | RNAi_result (20) | |||||
Expr_pattern | Expr1463 | |||||
Expr8941 | ||||||
Expr12554 | ||||||
Expr16070 | ||||||
Expr1019676 | ||||||
Expr1031535 | ||||||
Expr1145980 | ||||||
Expr2013570 | ||||||
Expr2031803 | ||||||
Drives_construct | WBCnstr00000269 | |||||
WBCnstr00001031 | ||||||
WBCnstr00001032 | ||||||
WBCnstr00036166 | ||||||
Construct_product | WBCnstr00001031 | |||||
WBCnstr00007681 | ||||||
WBCnstr00007697 | ||||||
WBCnstr00009004 | ||||||
WBCnstr00017999 | ||||||
WBCnstr00036166 | ||||||
Microarray_results (25) | ||||||
Expression_cluster (122) | ||||||
Interaction (285) | ||||||
WBProcess | WBbiopr:00000006 | |||||
WBbiopr:00000015 | ||||||
WBbiopr:00000107 | ||||||
WBbiopr:00000111 | ||||||
Map_info (4) | ||||||
Reference (178) | ||||||
Remark | Data extracted from Zipkin et al. (1997) | |||||
Method | Gene |