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WormBase Tree Display for Gene: WBGene00003239

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Name Class

WBGene00003239SMapS_parentSequenceC35C5
IdentityVersion1
NameCGC_namemig-2Person_evidenceWBPerson261
Sequence_nameC35C5.4
Molecular_nameC35C5.4a
C35C5.4a.1
CE18544
C35C5.4b
CE50721
C35C5.4b.1
Other_nameCELE_C35C5.4Accession_evidenceNDBBX284606
Public_namemig-2
DB_infoDatabaseAceViewgeneXM167
WormQTLgeneWBGene00003239
WormFluxgeneWBGene00003239
NDBlocus_tagCELE_C35C5.4
PanthergeneCAEEL|WormBase=WBGene00003239|UniProtKB=G5EBV3
familyPTHR24072
NCBIgene181344
RefSeqproteinNM_077530.5
NM_001313405.4
TrEMBLUniProtAccA0A0K3AYI6
G5EBV3
UniProt_GCRPUniProtAccG5EBV3
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:31WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmig
Allele (39)
Legacy_informationrh17 : variable abnormal migration of Q neuroblasts HSN cells CAN cells.
[C.elegansII] rh17 : variable abnormal migration of Q neuroblasts, HSN cells, CAN cells etc.; Egl; uncoordinated; axon defects. OA1. [Hedgecock et al. 1987; Desai et al. 1988; NJ]
[Zipkin ID, Kindt RM, Kenyon CJ] mu28 homozygotes exhibit abnormal migration of Q daughters. Predicted gene C35C5.4, encodes Rho-related protein.
StrainWBStrain00024138
WBStrain00024141
WBStrain00024146
WBStrain00024159
WBStrain00024170
WBStrain00024172
WBStrain00028737
WBStrain00028748
WBStrain00032460
WBStrain00004808
RNASeq_FPKM (74)
GO_annotation (56)
Ortholog (39)
ParalogWBGene00000390Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000424Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004357Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004287Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00022177Caenorhabditis elegansFrom_analysisPanther
WBGene00009059Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00012532Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00019544Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionmig-2 encodes a member of the RhoG family of GTP-binding proteins; MIG-2 activity is required for migration of Q neuroblasts, HSN neurons, and CAN cells as well as neurite outgrowth and guidance; in regulating Q neuroblast migration and dendrite outgrowth, MIG-2 functions upstream of the ANI-1 anillin to asymmetrically regulate ANI-1 localization, and thus stabilize F-actin, at the leading edge and growth cone; MIG-2 is expressed in early embryos and in adults in the vulva, gonadal distal tip cells, and the sex myoblasts and their descendants.Paper_evidenceWBPaper00046615
WBPaper00002878
Curator_confirmedWBPerson48
WBPerson1843
WBPerson567
Date_last_updated28 May 2015 00:00:00
Automated_descriptionEnables GTPase activity and protein kinase binding activity. Involved in several processes, including actin cytoskeleton organization; axon guidance; and cell migration. Located in cytoplasm; cytoplasmic side of plasma membrane; and neuron projection. Expressed in several structures, including CAN; HSN; distal tip cell; touch receptor neurons; and vulval cell. Used to study epilepsy. Is an ortholog of human RHOG (ras homolog family member G).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1826Homo sapiensPaper_evidenceWBPaper00035198
Curator_confirmedWBPerson38202
Date_last_updated04 Jun 2018 00:00:00
Models_disease_assertedWBDOannot00000557
Molecular_infoCorresponding_CDSC35C5.4a
C35C5.4b
Corresponding_transcriptC35C5.4a.1
C35C5.4b.1
Other_sequence (25)
Associated_featureWBsf663364
WBsf1007033
WBsf1007034
WBsf1007035
WBsf236390
WBsf236391
WBsf236392
WBsf236393
WBsf236394
Experimental_infoRNAi_result (20)
Expr_patternExpr1463
Expr8941
Expr12554
Expr16070
Expr1019676
Expr1031535
Expr1145980
Expr2013570
Expr2031803
Drives_constructWBCnstr00000269
WBCnstr00001031
WBCnstr00001032
WBCnstr00036166
Construct_productWBCnstr00001031
WBCnstr00007681
WBCnstr00007697
WBCnstr00009004
WBCnstr00017999
WBCnstr00036166
Microarray_results (25)
Expression_cluster (122)
Interaction (285)
WBProcessWBbiopr:00000006
WBbiopr:00000015
WBbiopr:00000107
WBbiopr:00000111
Map_infoMapXPosition4.35742Error0.06415
Well_ordered
PositivePositive_cloneC35C5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point3673
ReferenceWBPaper00000978
WBPaper00001105
WBPaper00001704
WBPaper00002001
WBPaper00002878
WBPaper00002978
WBPaper00003652
WBPaper00003706
WBPaper00004212
WBPaper00004216
WBPaper00004263
WBPaper00004448
WBPaper00004493
WBPaper00004746
WBPaper00004883
WBPaper00004959
WBPaper00005004
WBPaper00005104
WBPaper00005123
WBPaper00005218
WBPaper00005495
WBPaper00005607
WBPaper00005719
WBPaper00005792
WBPaper00006008
WBPaper00006109
WBPaper00006196
WBPaper00006422
WBPaper00010311
WBPaper00010399
WBPaper00010475
WBPaper00010504
WBPaper00010547
WBPaper00010591
WBPaper00011146
WBPaper00011307
WBPaper00011318
WBPaper00011964
WBPaper00012417
WBPaper00012521
WBPaper00012541
WBPaper00012547
WBPaper00012556
WBPaper00013415
WBPaper00013425
WBPaper00015578
WBPaper00015579
WBPaper00015687
WBPaper00015693
WBPaper00016590
WBPaper00017041
WBPaper00017093
WBPaper00017251
WBPaper00017272
WBPaper00017339
WBPaper00017425
WBPaper00017460
WBPaper00017538
WBPaper00017758
WBPaper00017864
WBPaper00017884
WBPaper00018102
WBPaper00018584
WBPaper00018831
WBPaper00019270
WBPaper00019305
WBPaper00019314
WBPaper00019316
WBPaper00019552
WBPaper00019663
WBPaper00022443
WBPaper00023315
WBPaper00023401
WBPaper00023540
WBPaper00023580
WBPaper00023691
WBPaper00023724
WBPaper00023800
WBPaper00024670
WBPaper00024961
WBPaper00025002
WBPaper00025137
WBPaper00025151
WBPaper00025306
WBPaper00025600
WBPaper00025743
WBPaper00025753
WBPaper00025846
WBPaper00026061
WBPaper00026148
WBPaper00026343
WBPaper00026580
WBPaper00026588
WBPaper00026774
WBPaper00026842
WBPaper00026850
WBPaper00026923
WBPaper00027071
WBPaper00027119
WBPaper00027144
WBPaper00027228
WBPaper00027291
WBPaper00027296
WBPaper00027316
WBPaper00028086
WBPaper00028087
WBPaper00028184
WBPaper00028497
WBPaper00028729
WBPaper00029052
WBPaper00029053
WBPaper00029135
WBPaper00029156
WBPaper00030273
WBPaper00030828
WBPaper00030886
WBPaper00031002
WBPaper00032090
WBPaper00032195
WBPaper00032405
WBPaper00032446
WBPaper00032793
WBPaper00032908
WBPaper00033059
WBPaper00033507
WBPaper00033512
WBPaper00034039
WBPaper00035198
WBPaper00035279
WBPaper00035284
WBPaper00035362
WBPaper00035583
WBPaper00035920
WBPaper00035978
WBPaper00036252
WBPaper00036644
WBPaper00036828
WBPaper00037174
WBPaper00037834
WBPaper00037900
WBPaper00038084
WBPaper00038091
WBPaper00038247
WBPaper00038317
WBPaper00038491
WBPaper00038671
WBPaper00038852
WBPaper00039146
WBPaper00039196
WBPaper00041771
WBPaper00043289
WBPaper00043290
WBPaper00043301
WBPaper00044133
WBPaper00044874
WBPaper00045955
WBPaper00045996
WBPaper00046000
WBPaper00046150
WBPaper00046168
WBPaper00046615
WBPaper00046690
WBPaper00047917
WBPaper00048425
WBPaper00048569
WBPaper00048842
WBPaper00050367
WBPaper00050583
WBPaper00052274
WBPaper00052994
WBPaper00054482
WBPaper00055090
WBPaper00055332
WBPaper00057613
WBPaper00058359
WBPaper00061412
WBPaper00061750
WBPaper00064400
RemarkData extracted from Zipkin et al. (1997)
MethodGene