WormBase Tree Display for Gene: WBGene00002978
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| WBGene00002978 | SMap | S_parent | Sequence | Y105E8B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lev-11 | Person_evidence | WBPerson368 | |||||
| Sequence_name | Y105E8B.1 | ||||||||
| Molecular_name (58) | |||||||||
| Other_name | tmy-1 | ||||||||
| Y105E8B.c | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CeTM | Paper_evidence | WBPaper00005168 | |||||||
| WBPaper00032338 | |||||||||
| CELE_Y105E8B.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lev-11 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lev | ||||||||
| Reference_allele | WBVar00275207 | ||||||||
| Allele | WBVar00248753 | Inferred_automatically | From strain object: RW3534 | ||||||
| WBVar00248768 | Inferred_automatically | From strain object: RW3566 | |||||||
| WBVar00275206 | Inferred_automatically | From strain object: ZZ1 | |||||||
| WBVar00248777 | |||||||||
| WBVar00242238 | |||||||||
| WBVar00144257 | |||||||||
| WBVar02159334 | |||||||||
| WBVar00692995 | |||||||||
| WBVar00692996 | |||||||||
| WBVar00692997 | |||||||||
| WBVar02017066 | |||||||||
| WBVar00259293 | |||||||||
| WBVar00352868 | |||||||||
| WBVar00352869 | |||||||||
| WBVar00352870 | |||||||||
| WBVar00352871 | |||||||||
| WBVar00352872 | |||||||||
| WBVar00352873 | |||||||||
| WBVar02129098 | |||||||||
| WBVar00352874 | |||||||||
| WBVar02129099 | |||||||||
| WBVar00352875 | |||||||||
| WBVar02129100 | |||||||||
| WBVar00352876 | |||||||||
| WBVar00352877 | |||||||||
| WBVar00352878 | |||||||||
| WBVar00352879 | |||||||||
| WBVar01715152 | |||||||||
| WBVar01715153 | |||||||||
| WBVar00352880 | |||||||||
| WBVar00352881 | |||||||||
| WBVar01715154 | |||||||||
| WBVar00352882 | |||||||||
| WBVar00352883 | |||||||||
| WBVar00142649 | |||||||||
| WBVar00352884 | |||||||||
| WBVar00275207 | |||||||||
| WBVar00352885 | |||||||||
| WBVar00352886 | |||||||||
| WBVar00352887 | |||||||||
| WBVar00352888 | |||||||||
| WBVar02011378 | |||||||||
| WBVar00352889 | |||||||||
| WBVar01290468 | |||||||||
| WBVar00352890 | |||||||||
| WBVar01290469 | |||||||||
| WBVar01499739 | |||||||||
| WBVar01290470 | |||||||||
| WBVar00352891 | |||||||||
| WBVar00352892 | |||||||||
| WBVar00352893 | |||||||||
| WBVar00352894 | |||||||||
| WBVar00352895 | |||||||||
| WBVar00352896 | |||||||||
| WBVar00352897 | |||||||||
| WBVar00352898 | |||||||||
| WBVar00352899 | |||||||||
| WBVar00352900 | |||||||||
| WBVar00249011 | |||||||||
| WBVar00352901 | |||||||||
| WBVar00352902 | |||||||||
| WBVar00352903 | |||||||||
| WBVar00352904 | |||||||||
| WBVar00352905 | |||||||||
| WBVar00352906 | |||||||||
| WBVar00352907 | |||||||||
| WBVar01356634 | |||||||||
| WBVar01356645 | |||||||||
| WBVar01356656 | |||||||||
| WBVar01356674 | |||||||||
| WBVar01891255 | |||||||||
| WBVar01356676 | |||||||||
| WBVar01891256 | |||||||||
| WBVar00241501 | |||||||||
| WBVar02151120 | |||||||||
| WBVar00598090 | |||||||||
| WBVar01235773 | |||||||||
| WBVar00277508 | |||||||||
| WBVar01429192 | |||||||||
| WBVar01429193 | |||||||||
| WBVar00317324 | |||||||||
| WBVar01429194 | |||||||||
| WBVar01429198 | |||||||||
| WBVar01429200 | |||||||||
| WBVar02074609 | |||||||||
| WBVar01429201 | |||||||||
| WBVar01429202 | |||||||||
| WBVar01235784 | |||||||||
| WBVar01392813 | |||||||||
| WBVar01392815 | |||||||||
| WBVar01235795 | |||||||||
| WBVar01993792 | |||||||||
| WBVar00692911 | |||||||||
| WBVar00692912 | |||||||||
| WBVar00692913 | |||||||||
| WBVar00692914 | |||||||||
| WBVar00692915 | |||||||||
| WBVar00692916 | |||||||||
| WBVar00692917 | |||||||||
| WBVar00692918 | |||||||||
| WBVar00692919 | |||||||||
| WBVar00692920 | |||||||||
| WBVar00692921 | |||||||||
| WBVar00692922 | |||||||||
| WBVar00692923 | |||||||||
| WBVar00248312 | |||||||||
| WBVar00692924 | |||||||||
| WBVar00248313 | |||||||||
| WBVar00692925 | |||||||||
| WBVar00692926 | |||||||||
| WBVar01499999 | |||||||||
| WBVar00692927 | |||||||||
| WBVar00692928 | |||||||||
| WBVar01557665 | |||||||||
| WBVar00692929 | |||||||||
| WBVar01915533 | |||||||||
| WBVar01557666 | |||||||||
| WBVar00692930 | |||||||||
| WBVar01557667 | |||||||||
| WBVar01948593 | |||||||||
| WBVar00692931 | |||||||||
| WBVar00692932 | |||||||||
| WBVar00692933 | |||||||||
| WBVar00692934 | |||||||||
| WBVar01499823 | |||||||||
| WBVar00692935 | |||||||||
| WBVar01499641 | |||||||||
| WBVar00692936 | |||||||||
| WBVar00692937 | |||||||||
| WBVar02009958 | |||||||||
| WBVar00692938 | |||||||||
| WBVar00162291 | |||||||||
| WBVar00692939 | |||||||||
| WBVar00692940 | |||||||||
| WBVar00162292 | |||||||||
| WBVar00692941 | |||||||||
| WBVar00162293 | |||||||||
| WBVar00692942 | |||||||||
| WBVar00162294 | |||||||||
| WBVar00162295 | |||||||||
| WBVar00692943 | |||||||||
| WBVar00692944 | |||||||||
| WBVar00692945 | |||||||||
| WBVar00692946 | |||||||||
| WBVar00692947 | |||||||||
| WBVar00692948 | |||||||||
| WBVar01404136 | |||||||||
| WBVar00692949 | |||||||||
| WBVar00692950 | |||||||||
| WBVar00692951 | |||||||||
| WBVar00692952 | |||||||||
| WBVar01495977 | |||||||||
| WBVar00692953 | |||||||||
| WBVar01435003 | |||||||||
| WBVar00692954 | |||||||||
| WBVar01435004 | |||||||||
| WBVar00692955 | |||||||||
| WBVar00692956 | |||||||||
| WBVar00692957 | |||||||||
| WBVar00692958 | |||||||||
| WBVar01497271 | |||||||||
| WBVar00692959 | |||||||||
| WBVar00692960 | |||||||||
| WBVar00692961 | |||||||||
| WBVar01499298 | |||||||||
| WBVar00692962 | |||||||||
| WBVar00692963 | |||||||||
| WBVar00692964 | |||||||||
| WBVar02039772 | |||||||||
| WBVar00692965 | |||||||||
| WBVar02039775 | |||||||||
| WBVar00692966 | |||||||||
| WBVar00692967 | |||||||||
| WBVar00692968 | |||||||||
| WBVar01412325 | |||||||||
| WBVar00692969 | |||||||||
| WBVar00692970 | |||||||||
| WBVar01498939 | |||||||||
| WBVar00692971 | |||||||||
| WBVar00692972 | |||||||||
| WBVar00543090 | |||||||||
| WBVar00692973 | |||||||||
| WBVar00692974 | |||||||||
| WBVar00692975 | |||||||||
| WBVar00692976 | |||||||||
| WBVar00692977 | |||||||||
| WBVar00692978 | |||||||||
| WBVar00692979 | |||||||||
| WBVar00692980 | |||||||||
| WBVar00692981 | |||||||||
| WBVar00692982 | |||||||||
| WBVar00692983 | |||||||||
| WBVar00692984 | |||||||||
| WBVar00692985 | |||||||||
| WBVar00692986 | |||||||||
| WBVar01502635 | |||||||||
| WBVar01502636 | |||||||||
| WBVar00692987 | |||||||||
| WBVar00692988 | |||||||||
| WBVar00692989 | |||||||||
| WBVar00692990 | |||||||||
| WBVar00692991 | |||||||||
| WBVar00692992 | |||||||||
| WBVar00692993 | |||||||||
| WBVar02028552 | |||||||||
| WBVar00692994 | |||||||||
| Legacy_information | x12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal). | ||||||||
| See also e1724 | |||||||||
| [Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping. | |||||||||
| [C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS. | |||||||||
| [C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK] | |||||||||
| Strain | WBStrain00002959 | ||||||||
| WBStrain00033515 | |||||||||
| WBStrain00033518 | |||||||||
| WBStrain00033524 | |||||||||
| WBStrain00040917 | |||||||||
| WBStrain00040918 | |||||||||
| WBStrain00004923 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (47) | |||||||||
| Structured_description | Concise_description | lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. | Paper_evidence | WBPaper00002748 | |||||
| WBPaper00004944 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111597 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||
| DOID:0110926 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
| DOID:0110309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
| DOID:0110457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
| DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
| DOID:0110932 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||||
| DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
| DOID:0080102 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
| DOID:2218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12013) | ||||||
| Molecular_info | Corresponding_CDS (19) | ||||||||
| Corresponding_CDS_history | Y105E8B.1b:wp62 | ||||||||
| Y105E8B.1b:wp114 | |||||||||
| Y105E8B.1c:wp62 | |||||||||
| Corresponding_transcript (20) | |||||||||
| Other_sequence (913) | |||||||||
| Associated_feature (35) | |||||||||
| Experimental_info | RNAi_result (31) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00010369 | ||||||||
| WBCnstr00012505 | |||||||||
| WBCnstr00016244 | |||||||||
| WBCnstr00041176 | |||||||||
| Antibody | WBAntibody00000099 | ||||||||
| WBAntibody00000422 | |||||||||
| WBAntibody00000423 | |||||||||
| WBAntibody00000472 | |||||||||
| Microarray_results (61) | |||||||||
| Expression_cluster (304) | |||||||||
| Interaction (175) | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | I | Position | 25.8125 | Error | 0.018971 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y105E8B | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | 2_point | 209 | |||||||
| 213 | |||||||||
| 214 | |||||||||
| 327 | |||||||||
| 5106 | |||||||||
| 6076 | |||||||||
| Multi_point (11) | |||||||||
| Pos_neg_data (13) | |||||||||
| Reference (90) | |||||||||
| Remark | Data extracted from Williams & Waterston 1994 | ||||||||
| The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02 | |||||||||
| Method | Gene |
