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WormBase Tree Display for Gene: WBGene00002275

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Name Class

WBGene00002275EvidencePaper_evidenceWBPaper00004339
SMapS_parentSequenceCHROMOSOME_II
IdentityVersion1
NameCGC_namelem-2
Sequence_nameW01G7.5
Molecular_nameW01G7.5
W01G7.5.1
CE20129
Other_nameY39G8C.aCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CeMAN1Paper_evidenceWBPaper00024687
CELE_W01G7.5Accession_evidenceNDBBX284602
Public_namelem-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlem
Allele (91)
Possibly_affected_byWBVar02153030
StrainWBStrain00036509
WBStrain00003846
WBStrain00047808
RNASeq_FPKM (74)
GO_annotation (28)
Contained_in_operonCEOP2724
Ortholog (26)
Structured_descriptionConcise_descriptionlem-2 encodes the ortholog of the vertebrate LEM2 and MAN1 proteins and contains a LEM domain which is a defining 40 amino acid motif shared by a family of nuclear envelope proteins; LEM family proteins bind to lamins and to the small inner nuclear membrane associated protein BAF; LEM-2 provides an anchor by which chromosomes are attached to the nuclear membrane; lem-2 together with the LEM domain protein emr-1/emerin, bind lmn-1/lamin and are required for viability and proper chromosome segregation; LEM-2 localizes to the nuclear membrane; lem-2 mutations also exhibit moderate hypersensitivity to DNA damage.Paper_evidenceWBPaper00005828
WBPaper00037942
WBPaper00040826
Curator_confirmedWBPerson1843
WBPerson324
Date_last_updated12 Apr 2012 00:00:00
Automated_descriptionEnables chromatin DNA binding activity and lamin binding activity. Involved in several processes, including mitotic cytokinesis; organelle organization; and response to X-ray. Located in chromosome and nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy and cataract 46 juvenile-onset. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Is an ortholog of human LEMD2 (LEM domain nuclear envelope protein 2) and LEMD3 (LEM domain containing 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:11726Homo sapiensPaper_evidenceWBPaper00046424
Accession_evidenceOMIM181350
Curator_confirmedWBPerson324
Date_last_updated04 Jan 2013 00:00:00
DOID:0110243Homo sapiensPaper_evidenceWBPaper00059881
Curator_confirmedWBPerson324
Date_last_updated27 Jun 2020 00:00:00
Potential_modelDOID:0111536Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:28887)
DOID:0110243Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:21244)
Disease_relevanceMutations in the human ortholog of lem-2, LEMD3, which encodes the MAN1 nuclear membrane protein, are found in Buschke-Ollendorff syndrome, Melorheostosis and Osteopoikilosis; MAN1 belongs to the family of LEM domain proteins that bind lamin and include nuclear lamina proteins like Emerin, LEM2/NET25, and several others; much of the knowledge of the organization and assembly of the nuclear lamina has come from studies in elegans; studies in elegans have demonstrated the overlapping roles of emerin and LEM-2 in embryogenesis, cell proliferation, lamin and heterochromatin organization; worm emerin and lem-2 are also involved in mitosis, smooth and striated muscle function, lifespan and meiotic progression, pointing to the many underlying processes that may affect disease phenotypes.Homo sapiensPaper_evidenceWBPaper00040268
Accession_evidenceOMIM166700
155950
16670
607844
Curator_confirmedWBPerson324
Date_last_updated06 Mar 2012 00:00:00
Models_disease_assertedWBDOannot00000047
WBDOannot00000768
WBDOannot00000769
WBDOannot00000770
WBDOannot00000771
Molecular_infoCorresponding_CDSW01G7.5
Corresponding_transcriptW01G7.5.1
Other_sequence (19)
Associated_featureWBsf644830
WBsf658388
WBsf976399
WBsf976400
WBsf981354
WBsf990618
WBsf1013767
WBsf222419
WBsf222420
WBsf222421
Experimental_infoRNAi_result (15)
Expr_patternExpr9180
Expr10879
Expr11504
Expr12212
Expr1014258
Expr1031341
Expr1158080
Expr2013044
Expr2031276
Drives_constructWBCnstr00018933
WBCnstr00020602
Construct_productWBCnstr00001838
WBCnstr00017548
WBCnstr00018933
WBCnstr00020602
Regulate_expr_clusterWBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00044786:lem-2(tm1582)_downregulated
WBPaper00044786:lem-2(tm1582)_upregulated
AntibodyWBAntibody00000308
WBAntibody00000309
WBAntibody00000310
WBAntibody00000311
WBAntibody00001855
WBAntibody00002216
WBAntibody00002346
Microarray_results (22)
Expression_cluster (158)
InteractionWBInteraction000121203
WBInteraction000134063
WBInteraction000135515
WBInteraction000229278
WBInteraction000250984
WBInteraction000256562
WBInteraction000294132
WBInteraction000297029
WBInteraction000352325
WBInteraction000384020
WBInteraction000390740
WBInteraction000406603
WBInteraction000427584
WBInteraction000501383
WBInteraction000502597
WBInteraction000502735
WBInteraction000505178
WBInteraction000541579
WBInteraction000542322
WBInteraction000542323
WBInteraction000542728
WBInteraction000542762
WBInteraction000544761
WBInteraction000544762
WBInteraction000544763
WBInteraction000552855
WBInteraction000557550
WBInteraction000559522
WBInteraction000569490
WBInteraction000569491
WBInteraction000578867
WBInteraction000578869
WBInteraction000579028
WBInteraction000579029
WBInteraction000580129
Map_infoMapIIPosition22.3934Error0.004999
PositivePositive_cloneW01G7Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4984
4388
Pseudo_map_position
Reference (43)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene