WormBase Tree Display for Strain: WBStrain00047808
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| WBStrain00047808 | Status | Live | ||
|---|---|---|---|---|
| Genotype | lem-2(ca19) II. | |||
| Public_name | JM311 | |||
| Contains | Gene | WBGene00002275 | ||
| Variation | WBVar00145526 | |||
| WBVar02153030 | ||||
| Disease_info | Models_disease | DOID:0110243 | ||
| Models_disease_in_annotation | WBDOannot00000768 | |||
| Properties | Outcrossed | x2 | ||
| Mutagen | CRISPR_Cas9 | |||
| CGC_received | 24 Jun 2020 00:00:00 | |||
| Location | CGC | |||
| Made_by | WBPerson411 | |||
| Remark | [2020-06-24T00:34:33.921Z WBPerson712] New Strain: genotype: emr-1(gk119) | Paper: micropublication Using the C. elegans lem-2 Gene to Reconstruct the Human LEMD2 Mutation Associated with Hutterite-type Cataract/Cardiomyopathy | Curator_confirmed | WBPerson712 | |
| Overall healthy but reduced brood size and pharyngeal pumping rate. Synthetic lethal with emr-1(-). ca19 is a Leu to Arg mutation at position 16 of LEM-2, reconstituting a mutation in the American Hutterite Population that causes juvenile cataracts and premature cardiomyopathy. | Inferred_automatically | From CGC strain data | ||
| Species | Caenorhabditis elegans |
