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WormBase Tree Display for Gene: WBGene00002275

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Name Class

WBGene00002275EvidencePaper_evidenceWBPaper00004339
SMapS_parentSequenceCHROMOSOME_II
IdentityVersion1
NameCGC_namelem-2
Sequence_nameW01G7.5
Molecular_nameW01G7.5
W01G7.5.1
CE20129
Other_nameY39G8C.aCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CeMAN1Paper_evidenceWBPaper00024687
CELE_W01G7.5Accession_evidenceNDBBX284602
Public_namelem-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlem
Allele (91)
Possibly_affected_byWBVar02153030
StrainWBStrain00036509
WBStrain00003846
WBStrain00047808
RNASeq_FPKM (74)
GO_annotation (28)
Contained_in_operonCEOP2724
Ortholog (26)
Structured_descriptionConcise_descriptionlem-2 encodes the ortholog of the vertebrate LEM2 and MAN1 proteins and contains a LEM domain which is a defining 40 amino acid motif shared by a family of nuclear envelope proteins; LEM family proteins bind to lamins and to the small inner nuclear membrane associated protein BAF; LEM-2 provides an anchor by which chromosomes are attached to the nuclear membrane; lem-2 together with the LEM domain protein emr-1/emerin, bind lmn-1/lamin and are required for viability and proper chromosome segregation; LEM-2 localizes to the nuclear membrane; lem-2 mutations also exhibit moderate hypersensitivity to DNA damage.Paper_evidenceWBPaper00005828
WBPaper00037942
WBPaper00040826
Curator_confirmedWBPerson324
WBPerson1843
Date_last_updated12 Apr 2012 00:00:00
Automated_descriptionEnables chromatin DNA binding activity and lamin binding activity. Involved in several processes, including mitotic cytokinesis; organelle organization; and response to X-ray. Located in chromosome and nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy and cataract 46 juvenile-onset. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Is an ortholog of human LEMD2 (LEM domain nuclear envelope protein 2) and LEMD3 (LEM domain containing 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Disease_infoExperimental_modelDOID:11726Homo sapiensPaper_evidenceWBPaper00046424
Accession_evidenceOMIM181350
Curator_confirmedWBPerson324
Date_last_updated04 Jan 2013 00:00:00
DOID:0110243Homo sapiensPaper_evidenceWBPaper00059881
Curator_confirmedWBPerson324
Date_last_updated27 Jun 2020 00:00:00
Potential_modelDOID:0111536Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:28887)
DOID:0110243Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:21244)
Disease_relevanceMutations in the human ortholog of lem-2, LEMD3, which encodes the MAN1 nuclear membrane protein, are found in Buschke-Ollendorff syndrome, Melorheostosis and Osteopoikilosis; MAN1 belongs to the family of LEM domain proteins that bind lamin and include nuclear lamina proteins like Emerin, LEM2/NET25, and several others; much of the knowledge of the organization and assembly of the nuclear lamina has come from studies in elegans; studies in elegans have demonstrated the overlapping roles of emerin and LEM-2 in embryogenesis, cell proliferation, lamin and heterochromatin organization; worm emerin and lem-2 are also involved in mitosis, smooth and striated muscle function, lifespan and meiotic progression, pointing to the many underlying processes that may affect disease phenotypes.Homo sapiensPaper_evidenceWBPaper00040268
Accession_evidenceOMIM166700
155950
16670
607844
Curator_confirmedWBPerson324
Date_last_updated06 Mar 2012 00:00:00
Models_disease_assertedWBDOannot00000047
WBDOannot00000768
WBDOannot00000769
WBDOannot00000770
WBDOannot00000771
Molecular_infoCorresponding_CDSW01G7.5
Corresponding_transcriptW01G7.5.1
Other_sequence (19)
Associated_featureWBsf644830
WBsf658388
WBsf976399
WBsf976400
WBsf981354
WBsf990618
WBsf1013767
WBsf222419
WBsf222420
WBsf222421
Experimental_infoRNAi_result (15)
Expr_patternExpr9180
Expr10879
Expr11504
Expr12212
Expr1014258
Expr1031341
Expr1158080
Expr2013044
Expr2031276
Drives_constructWBCnstr00018933
WBCnstr00020602
Construct_productWBCnstr00001838
WBCnstr00017548
WBCnstr00018933
WBCnstr00020602
Regulate_expr_clusterWBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00044786:lem-2(tm1582)_downregulated
WBPaper00044786:lem-2(tm1582)_upregulated
AntibodyWBAntibody00000308
WBAntibody00000309
WBAntibody00000310
WBAntibody00000311
WBAntibody00001855
WBAntibody00002216
WBAntibody00002346
Microarray_results (22)
Expression_cluster (148)
Interaction (35)
Map_infoMapIIPosition22.3934Error0.004999
PositivePositive_cloneW01G7Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4984
4388
Pseudo_map_position
Reference (42)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene