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WormBase Tree Display for Variation: WBVar02153030

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Name Class

WBVar02153030NamePublic_nameca19
Sequence_detailsSeqStatusPending_curation
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00047807
WBStrain00047808
LaboratoryJM
StatusLive
AffectsGeneWBGene00002275
InteractorWBInteraction000569490
Possibly_affectsWBGene00002275RemarkCGC_name lem-2
DescriptionPhenotypeWBPhenotype:0000019Paper_evidenceWBPaper00059881
Curator_confirmedWBPerson712
Remarkboth lem-2 mutations show a slightly lower pharyngeal pumping rate; once again, the ca19 phenotype is slightly more severe than that of the complete gene knockout. The slower pumping rates shown by both mutants agree with previous observations made with the lem-2(tm1582) allele (Barkan et al.2012).Paper_evidenceWBPaper00059881
Curator_confirmedWBPerson712
Variation_effectAntimorph_gain_of_functionPaper_evidenceWBPaper00059881
Curator_confirmedWBPerson712
Phenotype_assayStrainWBStrain00047808Paper_evidenceWBPaper00059881
Curator_confirmedWBPerson712
WBPhenotype:0000154Paper_evidenceWBPaper00059881
Curator_confirmedWBPerson712
Remarkca19 brood size is significantly lower than is the brood size of the complete lem-2 knockout, i.e., the ca19 phenotype is 'worse' than the null phenotype. Thus ca19 could be described as a mild antimorph (Muller 1932) and this antimorph classification will be explained and defended below.Paper_evidenceWBPaper00059881
Curator_confirmedWBPerson712
Variation_effectAntimorph_gain_of_functionPaper_evidenceWBPaper00059881
Curator_confirmedWBPerson712
Phenotype_assayStrainWBStrain00047808Paper_evidenceWBPaper00059881
Curator_confirmedWBPerson712
ReferenceWBPaper00059881
Remark[2020-06-24T00:27:19.538Z WBPerson712] New Variation: lem-2 micropublication Using the C. elegans lem-2 Gene to Reconstruct the Human LEMD2; Mutation Associated with Hutterite-type Cataract/CardiomyopathyCurator_confirmedWBPerson712
MethodAllele