WormBase Tree Display for Gene: WBGene00002214

WBGene00002214 SMap: S_parent: Sequence: M7
  Identity: Version: 1
    Name: CGC_name: klc-1 Person_evidence: WBPerson589
      Sequence_name: M7.2
      Molecular_name: M7.2a
        M7.2a.1
        CE23882
        M7.2b
        CE47107
        M7.2b.1
      Other_name: CELE_M7.2 Accession_evidence: NDB BX284604
      Public_name: klc-1
    DB_info: Database: AceView gene 4L849
        WormQTL gene WBGene00002214
        WormFlux gene WBGene00002214
        NDB locus_tag CELE_M7.2
        Panther gene CAEEL|WormBase=WBGene00002214|UniProtKB=H9G2T2
          family PTHR45783
        NCBI gene 178007
        RefSeq protein NM_001268605.3
            NM_001268606.4
        TrEMBL UniProtAcc H9G2T2
            Q21592
        UniProt_GCRP UniProtAcc H9G2T2
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: klc
    Allele (36)
    Legacy_information: [Siddiqui SS ] Predicted gene M7.2. Related to kinesin light chain by sequence similarity.
    Strain: WBStrain00032659
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (35)
    Paralog: WBGene00002215 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: klc-1 encodes one of two C. elegans kinesin light chains; by homology, KLC-1 is predicted to function, along with kinesin-like heavy chains, as part of a multimeric kinesin complex involved in intracellular transport; consistent with this, KLC-1 has been shown to interact with UNC-116/kinesin, KCA-1/kinesin cargo adaptor, and the ARX-2/Arp2/3 complex component in yeast two-hybrid assays; RNAi experiments indicate that klc-1 activity is required for normal embryonic development. Paper_evidence: WBPaper00004211
            WBPaper00004540
            WBPaper00006332
            WBPaper00024617
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 May 2005 00:00:00
      Automated_description: Predicted to enable kinesin binding activity. Involved in establishment of meiotic spindle localization and polar body extrusion after meiotic divisions. Predicted to be located in cytoplasm. Predicted to be part of kinesin complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and relapsing-remitting multiple sclerosis. Is an ortholog of human KLC1 (kinesin light chain 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6387)
      DOID:2378 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6387)
  Molecular_info: Corresponding_CDS: M7.2a
      M7.2b
    Corresponding_transcript: M7.2a.1
      M7.2b.1
    Associated_feature: WBsf655053
      WBsf655054
      WBsf997761
      WBsf997762
      WBsf229093
      WBsf229094
  Experimental_info: RNAi_result (15)
    Expr_pattern: Expr8883
      Expr8884
      Expr1011689
      Expr1031294
      Expr1154758
      Expr2012947
      Expr2031179
    Drives_construct: WBCnstr00036382
    Construct_product: WBCnstr00013578
      WBCnstr00036382
    Antibody: WBAntibody00002083
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:AVA-neuron_embryo_enriched
      WBPaper00037950:AVA-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:CEP-sheath-cells_adult_enriched
      WBPaper00037950:CEP-sheath-cells_adult_SelectivelyEnriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00040560:hpl-2_L3_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045050:drh-3 (ne4253)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00050015:ifg-1(RNAi)_downregulated
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:NMDA-neuron_enriched
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051404:alg-5(ram2)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:mes-4(RNAi)_downregulated_fed-L1_Truseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Metformin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00058958:100mGy-irradiation-72h_downregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059174:MEG-3_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:CEPsh
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062587:lsl-1(ljm1)_downregulated
      WBPaper00062587:lsl-1(tm4769)_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F2
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      cgc4489_group_6
      WBPaper00025032:cluster_1
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030985:Serratia_marcesens_upregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_5
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_F
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037113:Diazinon_16C_regulated
      WBPaper00037147:heatshock_upregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040963:TA300_down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00051387:Triclosan_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_E
      [cgc6390]:intrinsic
    Interaction (231)
  Map_info: Map: IV Position: 4.83857 Error: 0.004896
    Positive: Positive_clone: M7 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene