WormBase Tree Display for Gene: WBGene00002215
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| WBGene00002215 | SMap | S_parent | Sequence | C18C4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | klc-2 | Person_evidence | WBPerson589 | |||||
| Sequence_name | C18C4.10 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | CELE_C18C4.10 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | klc-2 | ||||||||
| DB_info | Database | AceView | gene | 5G58 | |||||
| WormQTL | gene | WBGene00002215 | |||||||
| WormFlux | gene | WBGene00002215 | |||||||
| NDB | locus_tag | CELE_C18C4.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002215|UniProtKB=P46822 | |||||||
| family | PTHR45783 | ||||||||
| NCBI | gene | 178942 | |||||||
| RefSeq | protein | NM_001028493.7 | |||||||
| NM_001028494.5 | |||||||||
| NM_001028492.5 | |||||||||
| SwissProt | UniProtAcc | P46822 | |||||||
| UniProt_GCRP | UniProtAcc | P46822 | |||||||
| OMIM | gene | 611729 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | klc | ||||||||
| Allele (67) | |||||||||
| Legacy_information | [Siddiqui SS ] Predicted gene C18C4.10. Related to kinesin light chain by sequence similarity. | ||||||||
| Strain | WBStrain00001630 | ||||||||
| WBStrain00050735 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (58) | |||||||||
| Paralog | WBGene00002214 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | klc-2 encodes a kinesin light chain; klc-2 is required for transport and localization of synaptic vesicles to presynaptic terminals; in addition, klc-2 is required for normal translocation of the meiotic spindle to the oocyte cortex; KLC-2 physically interacts with UNC-116/kinesin heavy chain (KHC) and with UNC-16 and UNC-14, suggesting that it regulates vesicular transport by mediating the association between UNC-116/KHC and synaptic vesicles; a KLC-2::GFP fusion protein is widely expressed and seen in neurons, muscle, and the pharynx; in neurons, KLC-2::GFP exhibits diffuse localization. | Paper_evidence | WBPaper00004211 | |||||
| WBPaper00005014 | |||||||||
| WBPaper00005076 | |||||||||
| WBPaper00024617 | |||||||||
| WBPaper00025176 | |||||||||
| WBPaper00026866 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 13 Mar 2009 00:00:00 | ||||||||
| Automated_description | Enables kinesin binding activity. Involved in several processes, including axon extension; establishment of organelle localization; and polar body extrusion after meiotic divisions. Located in cytoplasm and nuclear envelope. Part of kinesin I complex. Expressed in body ganglion; muscle cell; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; SPOAN syndrome; and relapsing-remitting multiple sclerosis. Is an ortholog of human KLC1 (kinesin light chain 1) and KLC2 (kinesin light chain 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6387) | ||||
| DOID:2378 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6387) | ||||||
| DOID:0060491 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20716) | ||||||
| Molecular_info | Corresponding_CDS | C18C4.10a | |||||||
| C18C4.10b | |||||||||
| C18C4.10c | |||||||||
| Corresponding_CDS_history | C18C4.10b:wp90 | ||||||||
| C18C4.10d:wp261 | |||||||||
| Corresponding_transcript | C18C4.10a.1 | ||||||||
| C18C4.10b.1 | |||||||||
| C18C4.10b.2 | |||||||||
| C18C4.10b.3 | |||||||||
| C18C4.10c.1 | |||||||||
| Other_sequence (99) | |||||||||
| Associated_feature (19) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Chronogram513 | ||||||||
| Expr3209 | |||||||||
| Expr5301 | |||||||||
| Expr8662 | |||||||||
| Expr1012871 | |||||||||
| Expr1031295 | |||||||||
| Expr1144957 | |||||||||
| Expr2012948 | |||||||||
| Expr2031180 | |||||||||
| Drives_construct | WBCnstr00002469 | ||||||||
| WBCnstr00036381 | |||||||||
| Construct_product | WBCnstr00036381 | ||||||||
| Antibody | WBAntibody00001660 | ||||||||
| WBAntibody00002831 | |||||||||
| Microarray_results (43) | |||||||||
| Expression_cluster (138) | |||||||||
| Interaction (91) | |||||||||
| Map_info | Map | V | Position | -1.48452 | Error | 0.026086 | |||
| Positive | Positive_clone | C18C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4462 | |||||||
| 4944 | |||||||||
| 5254 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (36) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
