WormBase Tree Display for Gene: WBGene00002214
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| WBGene00002214 | SMap | S_parent | Sequence | M7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | klc-1 | Person_evidence | WBPerson589 | |||||
| Sequence_name | M7.2 | ||||||||
| Molecular_name | M7.2a | ||||||||
| M7.2a.1 | |||||||||
| CE23882 | |||||||||
| M7.2b | |||||||||
| CE47107 | |||||||||
| M7.2b.1 | |||||||||
| Other_name | CELE_M7.2 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | klc-1 | ||||||||
| DB_info | Database | AceView | gene | 4L849 | |||||
| WormQTL | gene | WBGene00002214 | |||||||
| WormFlux | gene | WBGene00002214 | |||||||
| NDB | locus_tag | CELE_M7.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002214|UniProtKB=H9G2T2 | |||||||
| family | PTHR45783 | ||||||||
| NCBI | gene | 178007 | |||||||
| RefSeq | protein | NM_001268605.3 | |||||||
| NM_001268606.4 | |||||||||
| TrEMBL | UniProtAcc | H9G2T2 | |||||||
| Q21592 | |||||||||
| UniProt_GCRP | UniProtAcc | H9G2T2 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | klc | ||||||||
| Allele (36) | |||||||||
| Legacy_information | [Siddiqui SS ] Predicted gene M7.2. Related to kinesin light chain by sequence similarity. | ||||||||
| Strain | WBStrain00032659 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (35) | |||||||||
| Paralog | WBGene00002215 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | klc-1 encodes one of two C. elegans kinesin light chains; by homology, KLC-1 is predicted to function, along with kinesin-like heavy chains, as part of a multimeric kinesin complex involved in intracellular transport; consistent with this, KLC-1 has been shown to interact with UNC-116/kinesin, KCA-1/kinesin cargo adaptor, and the ARX-2/Arp2/3 complex component in yeast two-hybrid assays; RNAi experiments indicate that klc-1 activity is required for normal embryonic development. | Paper_evidence | WBPaper00004211 | |||||
| WBPaper00004540 | |||||||||
| WBPaper00006332 | |||||||||
| WBPaper00024617 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 May 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable kinesin binding activity. Involved in establishment of meiotic spindle localization and polar body extrusion after meiotic divisions. Predicted to be located in cytoplasm. Predicted to be part of kinesin complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and relapsing-remitting multiple sclerosis. Is an ortholog of human KLC1 (kinesin light chain 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6387) | ||||
| DOID:2378 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6387) | ||||||
| Molecular_info | Corresponding_CDS | M7.2a | |||||||
| M7.2b | |||||||||
| Corresponding_transcript | M7.2a.1 | ||||||||
| M7.2b.1 | |||||||||
| Associated_feature | WBsf655053 | ||||||||
| WBsf655054 | |||||||||
| WBsf997761 | |||||||||
| WBsf997762 | |||||||||
| WBsf229093 | |||||||||
| WBsf229094 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr8883 | ||||||||
| Expr8884 | |||||||||
| Expr1011689 | |||||||||
| Expr1031294 | |||||||||
| Expr1154758 | |||||||||
| Expr2012947 | |||||||||
| Expr2031179 | |||||||||
| Drives_construct | WBCnstr00036382 | ||||||||
| Construct_product | WBCnstr00013578 | ||||||||
| WBCnstr00036382 | |||||||||
| Antibody | WBAntibody00002083 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (178) | |||||||||
| Interaction (231) | |||||||||
| Map_info | Map | IV | Position | 4.83857 | Error | 0.004896 | |||
| Positive | Positive_clone | M7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
