WormBase Tree Display for Gene: WBGene00002087

WBGene00002087 Evidence: Paper_evidence: WBPaper00003057
      WBPaper00004623
  SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: ins-4 Person_evidence: WBPerson339
      Sequence_name: ZK75.1
      Molecular_name: ZK75.1
        ZK75.1.1
        CE02100
      Other_name: ZK84.d Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_ZK75.1 Accession_evidence: NDB BX284602
      Public_name: ins-4
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ins
    Allele (17)
    Legacy_information: [Ferguson K] ins for INSulin related. No mutants known.
    Strain: WBStrain00033219
    RNASeq_FPKM (74)
    GO_annotation: 00055163
      00055164
      00055165
      00055166
      00055167
      00055168
      00055169
      00110004
      00110005
    Ortholog (27)
    Paralog (19)
    Structured_description: Concise_description: ins-4 encodes an insulin-like peptide. Paper_evidence: WBPaper00004623
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Oct 2006 00:00:00
      Automated_description: Predicted to enable hormone activity. Involved in dauer larval development; negative regulation of dauer entry; and regulation of synaptic assembly at neuromuscular junction. Predicted to be located in extracellular region. Expressed in several structures, including gonad; head muscle; neurons; somatic nervous system; and vulva. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK75.1
    Corresponding_transcript: ZK75.1.1
    Associated_feature: WBsf221379
  Experimental_info: RNAi_result: WBRNAi00022156 Inferred_automatically: RNAi_primary
      WBRNAi00038434 Inferred_automatically: RNAi_primary
      WBRNAi00107949 Inferred_automatically: RNAi_primary
      WBRNAi00059702 Inferred_automatically: RNAi_primary
    Expr_pattern (12)
    Drives_construct: WBCnstr00013426
      WBCnstr00017454
      WBCnstr00017774
      WBCnstr00017858
      WBCnstr00019808
      WBCnstr00036464
      WBCnstr00041245
      WBCnstr00042826
    Construct_product: WBCnstr00017858
      WBCnstr00036464
    Microarray_results (19)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040990:PA14_upregulated
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045017:blmp-1(tm548)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045774:clk-1_upregulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049377:MWCNT_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_7
      WBPaper00049635:dop-1(vs100)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050096:P.aeruginosa_upregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050717:let-7(n2853)_lin-41(xe11)_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059378:lmn-1(Y59C)_downregulated
      WBPaper00059426:Ag-nanoparticles_downregulated
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:ASI
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:flp-5-F17C11.2
      WBPaper00061651:ASER_enriched
      WBPaper00061651:ASI_enriched
      WBPaper00061651:URB_enriched
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062167:mbl-1(tm1563)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062347:blmp-1(tm548)_upregulated
      WBPaper00062491:sma-3(wk30)_downregulated
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064494:postdauer_downregulated_WholeAnimal
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065623:114
      WBPaper00065759:dot-1.1(knu339)_upregulated
      WBPaper00065841:35_4
      WBPaper00065841:77_0
      WBPaper00065841:99_0
      WBPaper00065841:106_0
      WBPaper00065841:145_0
      WBPaper00065841:146_0
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066204:CdCl2_upregulated_mRNA
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_12
      WBPaper00026952:class_B
      WBPaper00027111:rrf-1(pk1417)_upregulated
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:FedUp
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035424:ASER_up
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_F
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00040185:nhr-23(RNAi)_downregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00042548:miRISC_enriched
      WBPaper00044535:male_upregulated
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc6390]:mixed_spermatogenesis-somatic
    Interaction (102)
  Map_info: Map: II Position: -0.724881 Error: 0.006853
    Positive: Positive_clone: ZK75 Author_evidence: Ferguson KC
          Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (25)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene