WormBase Tree Display for Gene: WBGene00002044
expand all nodes | collapse all nodes | view schema
| WBGene00002044 | Evidence | Paper_evidence | WBPaper00003354 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K02G10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | hyl-2 | |||||||
| Sequence_name | K02G10.6 | ||||||||
| Molecular_name | K02G10.6 | ||||||||
| K02G10.6.1 | |||||||||
| CE34329 | |||||||||
| Other_name | CELE_K02G10.6 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | hyl-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hyl | ||||||||
| Allele (52) | |||||||||
| Strain | WBStrain00022202 | ||||||||
| WBStrain00032195 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (64) | |||||||||
| Paralog | WBGene00002043 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00007696 | |||||||||
| WBGene00006505 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | hyl-2 encodes a predicted transmembrane protein orthologous to Saccharomyces cerevisiae Lag1p (longevity assurance gene), a protein preferentially expressed in young yeasts; by homology, HYL-2 is predicted to have several possible functions, including regulation of lipid, particularly ceramide, biosynthesis, regulation of lipid transport, and regulation of protein translocation in the endoplasmic reticulum ; however, as loss of hyl-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of hyl-2 in C. elegans development and/or behavior is not yet known. | Paper_evidence | WBPaper00003354 | |||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to be located in membrane. Expressed in head; hypodermis; intestine; tail; and terminal bulb. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9. Is an ortholog of human CERS6 (ceramide synthase 6). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060718 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23752) | ||||
| Molecular_info | Corresponding_CDS | K02G10.6 | |||||||
| Corresponding_CDS_history | K02G10.6a:wp145 | ||||||||
| K02G10.6b:wp145 | |||||||||
| Corresponding_transcript | K02G10.6.1 | ||||||||
| Other_sequence (17) | |||||||||
| Associated_feature | WBsf1005034 | ||||||||
| WBsf1005035 | |||||||||
| WBsf1005036 | |||||||||
| WBsf1005037 | |||||||||
| WBsf1022835 | |||||||||
| WBsf1022836 | |||||||||
| WBsf1022837 | |||||||||
| WBsf237304 | |||||||||
| WBsf237305 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00016498 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00049770 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8765 | ||||||||
| Expr1012548 | |||||||||
| Expr1031198 | |||||||||
| Expr1153485 | |||||||||
| Expr2012658 | |||||||||
| Expr2030894 | |||||||||
| Drives_construct | WBCnstr00013503 | ||||||||
| WBCnstr00036497 | |||||||||
| Construct_product | WBCnstr00013503 | ||||||||
| WBCnstr00036497 | |||||||||
| Regulate_expr_cluster | WBPaper00049920:hyl-2(tm2031)_downregulated | ||||||||
| WBPaper00049920:hyl-2(tm2031)_upregulated | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (113) | |||||||||
| Interaction (72) | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| WBbiopr:00000137 | |||||||||
| Map_info | Map | X | Position | -6.89754 | Error | 0.008168 | |||
| Positive | Positive_clone | K02G10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5494 | |||||||
| 5264 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (21) | |||||||||
| Picture | WBPicture0000013061 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
