WormBase Tree Display for Gene: WBGene00002044

WBGene00002044 Evidence: Paper_evidence: WBPaper00003354
  SMap: S_parent: Sequence: K02G10
  Identity: Version: 1
    Name: CGC_name: hyl-2
      Sequence_name: K02G10.6
      Molecular_name: K02G10.6
        K02G10.6.1
        CE34329
      Other_name: CELE_K02G10.6 Accession_evidence: NDB BX284606
      Public_name: hyl-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hyl
    Allele (52)
    Strain: WBStrain00022202
      WBStrain00032195
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (64)
    Paralog: WBGene00002043 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007696
      WBGene00006505 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: hyl-2 encodes a predicted transmembrane protein orthologous to Saccharomyces cerevisiae Lag1p (longevity assurance gene), a protein preferentially expressed in young yeasts; by homology, HYL-2 is predicted to have several possible functions, including regulation of lipid, particularly ceramide, biosynthesis, regulation of lipid transport, and regulation of protein translocation in the endoplasmic reticulum ; however, as loss of hyl-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of hyl-2 in C. elegans development and/or behavior is not yet known. Paper_evidence: WBPaper00003354
            WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to be located in membrane. Expressed in head; hypodermis; intestine; tail; and terminal bulb. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9. Is an ortholog of human CERS6 (ceramide synthase 6). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060718 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:23752)
  Molecular_info: Corresponding_CDS: K02G10.6
    Corresponding_CDS_history: K02G10.6a:wp145
      K02G10.6b:wp145
    Corresponding_transcript: K02G10.6.1
    Other_sequence (17)
    Associated_feature: WBsf1005034
      WBsf1005035
      WBsf1005036
      WBsf1005037
      WBsf1022835
      WBsf1022836
      WBsf1022837
      WBsf237304
      WBsf237305
  Experimental_info: RNAi_result: WBRNAi00016498 Inferred_automatically: RNAi_primary
      WBRNAi00049770 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8765
      Expr1012548
      Expr1031198
      Expr1153485
      Expr2012658
      Expr2030894
    Drives_construct: WBCnstr00013503
      WBCnstr00036497
    Construct_product: WBCnstr00013503
      WBCnstr00036497
    Regulate_expr_cluster: WBPaper00049920:hyl-2(tm2031)_downregulated
      WBPaper00049920:hyl-2(tm2031)_upregulated
    Microarray_results (23)
    Expression_cluster (113)
    Interaction: WBInteraction000041837
      WBInteraction000114708
      WBInteraction000114709
      WBInteraction000114710
      WBInteraction000114725
      WBInteraction000114726
      WBInteraction000114727
      WBInteraction000114728
      WBInteraction000114729
      WBInteraction000114730
      WBInteraction000114731
      WBInteraction000114732
      WBInteraction000274553
      WBInteraction000279620
      WBInteraction000297967
      WBInteraction000331075
      WBInteraction000336377
      WBInteraction000336378
      WBInteraction000336379
      WBInteraction000336380
      WBInteraction000336381
      WBInteraction000336382
      WBInteraction000336383
      WBInteraction000336384
      WBInteraction000336385
      WBInteraction000336386
      WBInteraction000336387
      WBInteraction000336388
      WBInteraction000336389
      WBInteraction000336390
      WBInteraction000336391
      WBInteraction000336392
      WBInteraction000336393
      WBInteraction000336394
      WBInteraction000336395
      WBInteraction000336396
      WBInteraction000336397
      WBInteraction000336398
      WBInteraction000336399
      WBInteraction000336400
      WBInteraction000336401
      WBInteraction000336402
      WBInteraction000336403
      WBInteraction000336404
      WBInteraction000336405
      WBInteraction000336406
      WBInteraction000336407
      WBInteraction000336408
      WBInteraction000336409
      WBInteraction000336410
      WBInteraction000336411
      WBInteraction000336412
      WBInteraction000336413
      WBInteraction000336414
      WBInteraction000336415
      WBInteraction000336416
      WBInteraction000336417
      WBInteraction000336418
      WBInteraction000336419
      WBInteraction000336420
      WBInteraction000336421
      WBInteraction000336422
      WBInteraction000365069
      WBInteraction000418536
      WBInteraction000436070
      WBInteraction000441320
      WBInteraction000525071
      WBInteraction000525150
      WBInteraction000525151
      WBInteraction000525152
      WBInteraction000535441
      WBInteraction000585683
    WBProcess: WBbiopr:00000121
      WBbiopr:00000137
  Map_info: Map: X Position: -6.89754 Error: 0.008168
    Positive: Positive_clone: K02G10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5494
        5264
    Pseudo_map_position
  Reference (21)
  Picture: WBPicture0000013061
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene