| WBGene00002044 | Evidence | Paper_evidence | WBPaper00003354 |
|---|
| SMap | S_parent | Sequence | K02G10 |
| Identity | Version | 1 |
| | Name | CGC_name | hyl-2 |
| | | Sequence_name | K02G10.6 |
| | | Molecular_name | K02G10.6 |
| | | | K02G10.6.1 |
| | | | CE34329 |
| | | Other_name | CELE_K02G10.6 | Accession_evidence | NDB | BX284606 |
| | | Public_name | hyl-2 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | hyl |
| | Allele (52) |
| | Strain | WBStrain00022202 |
| | | WBStrain00032195 |
| | RNASeq_FPKM (74) |
| | GO_annotation (11) |
| | Ortholog (64) |
| | Paralog | WBGene00002043 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00007696 |
| | | WBGene00006505 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | hyl-2 encodes a predicted transmembrane protein orthologous to Saccharomyces cerevisiae Lag1p (longevity assurance gene), a protein preferentially expressed in young yeasts; by homology, HYL-2 is predicted to have several possible functions, including regulation of lipid, particularly ceramide, biosynthesis, regulation of lipid transport, and regulation of protein translocation in the endoplasmic reticulum ; however, as loss of hyl-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of hyl-2 in C. elegans development and/or behavior is not yet known. | Paper_evidence | WBPaper00003354 |
| | | | | | WBPaper00005654 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to be located in membrane. Expressed in head; hypodermis; intestine; tail; and terminal bulb. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9. Is an ortholog of human CERS6 (ceramide synthase 6). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0060718 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23752) |
| Molecular_info | Corresponding_CDS | K02G10.6 |
| | Corresponding_CDS_history | K02G10.6a:wp145 |
| | | K02G10.6b:wp145 |
| | Corresponding_transcript | K02G10.6.1 |
| | Other_sequence (17) |
| | Associated_feature | WBsf1005034 |
| | | WBsf1005035 |
| | | WBsf1005036 |
| | | WBsf1005037 |
| | | WBsf1022835 |
| | | WBsf1022836 |
| | | WBsf1022837 |
| | | WBsf237304 |
| | | WBsf237305 |
| Experimental_info | RNAi_result | WBRNAi00016498 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00049770 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr8765 |
| | | Expr1012548 |
| | | Expr1031198 |
| | | Expr1153485 |
| | | Expr2012658 |
| | | Expr2030894 |
| | Drives_construct | WBCnstr00013503 |
| | | WBCnstr00036497 |
| | Construct_product | WBCnstr00013503 |
| | | WBCnstr00036497 |
| | Regulate_expr_cluster | WBPaper00049920:hyl-2(tm2031)_downregulated |
| | | WBPaper00049920:hyl-2(tm2031)_upregulated |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00030922:glycosylated_protein |
| | | WBPaper00032031:DConiospora_downregulated_OligoArray_24h |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:hyl-2(tm2031)_downregulated |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050686:glp-1(e2141)_upregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Body_wall_muscle |
| | | WBPaper00061340:GLR |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061527:kin-2_4858-ncx-2_21852 |
| | | WBPaper00061572:oleic-acid-specific_mating_downregulated |
| | | WBPaper00062590:Aging_downregulated_body-wall-muscle |
| | | WBPaper00062590:Aging_downregulated_hypodermis |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064107:lin-35(n745)_downregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4489_group_17 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:eri-1(mg366)_upregulated |
| | | WBPaper00027111:rde-3(r459)_upregulated |
| | | WBPaper00030985:Erwinia_carotovora_downregulated |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | Interaction (72) |
| | WBProcess | WBbiopr:00000121 |
| | | WBbiopr:00000137 |
| Map_info | Map | X | Position | -6.89754 | Error | 0.008168 |
| | Positive | Positive_clone | K02G10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5494 |
| | | | 5264 |
| | Pseudo_map_position |
| Reference (21) |
| Picture | WBPicture0000013061 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
