| WBGene00002015 | SMap | S_parent | Sequence | T27E4 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | hsp-16.1 | Person_evidence | WBPerson36 |
| | | Sequence_name | T27E4.8 |
| | | Molecular_name | T27E4.8 |
| | | | T27E4.8.1 |
| | | | CE14249 |
| | | Other_name | hsp-16 |
| | | | CELE_T27E4.8 | Accession_evidence | NDB | BX284605 |
| | | Public_name | hsp-16.1 |
| | DB_info | Database | AceView | gene | 5J568 |
| | | | WormQTL | gene | WBGene00002015 |
| | | | WormFlux | gene | WBGene00002015 |
| | | | NDB | locus_tag | CELE_T27E4.8 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00002015|UniProtKB=P34696 |
| | | | | family | PTHR45640 |
| | | | NCBI | gene | 179286 |
| | | | RefSeq | protein | NM_072953.5 |
| | | | SwissProt | UniProtAcc | P34696 |
| | | | UniProt_GCRP | UniProtAcc | P34696 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | hsp |
| | Allele | WBVar01499903 |
| | | WBVar01500129 |
| | | WBVar00091863 |
| | | WBVar01499419 |
| | | WBVar01499420 |
| | | WBVar01499056 |
| | | WBVar01499249 |
| | | WBVar01499316 |
| | Strain | WBStrain00004819 |
| | | WBStrain00004820 |
| | | WBStrain00030548 |
| | | WBStrain00030720 |
| | | WBStrain00030838 |
| | In_cluster | HSP16A |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00044149 |
| | | 00044150 |
| | | 00044151 |
| | | 00044152 |
| | | 00044153 |
| | | 00044154 |
| | | 00105765 |
| | | 00105800 |
| | | 00106135 |
| | | 00106136 |
| | Ortholog (91) |
| | Paralog (17) |
| | Structured_description | Concise_description | hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. | Paper_evidence | WBPaper00001187 |
| | | | | | WBPaper00001497 |
| | | | | | WBPaper00002665 |
| | | | | | WBPaper00004424 |
| | | | | | WBPaper00013029 |
| | | | | | WBPaper00013239 |
| | | | | | WBPaper00013280 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 05 Nov 2004 00:00:00 |
| | | Automated_description | Predicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Located in Golgi medial cisterna. Expressed in several structures, including coelomocyte; enteric muscle; intestine; pharynx; and ventral nerve cord. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. | Homo sapiens | Paper_evidence | WBPaper00041564 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 29 May 2013 00:00:00 |
| Molecular_info | Corresponding_CDS | T27E4.8 |
| | Corresponding_transcript | T27E4.8.1 |
| | Other_sequence (60) |
| | Associated_feature | WBsf977958 | Paper_evidence | WBPaper00000918 |
| | | WBsf977959 | Paper_evidence | WBPaper00000918 |
| | | WBsf977962 |
| | | WBsf1000813 |
| | | WBsf234177 |
| | | WBsf234178 |
| Experimental_info | RNAi_result (21) |
| | Expr_pattern | Expr1381 |
| | | Expr1384 |
| | | Expr10597 |
| | | Expr11025 |
| | | Expr15516 |
| | | Expr1157862 |
| | | Expr2012617 |
| | | Expr2030853 |
| | Drives_construct (37) |
| | Construct_product | WBCnstr00010254 |
| | | WBCnstr00017024 |
| | | WBCnstr00019264 |
| | | WBCnstr00036521 |
| | | WBCnstr00042207 |
| | Antibody | WBAntibody00000049 |
| | | WBAntibody00001859 |
| | Microarray_results (24) |
| | Expression_cluster | WBPaper00005432:xbp-1(zc12)_downregulated |
| | | WBPaper00006047:15C_temperature_specific |
| | | WBPaper00032009:nhr-40(ok667)_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00034755:ALG-1_interacting |
| | | WBPaper00036231:long-telomeres_upregulated |
| | | WBPaper00036291:ung-1_regulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038118:stress_upregulated_N2 |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038357:atx-3_regulated_heat-shock |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040135:heat-shock_upregulated |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040731:Static_Magnetic_Field_upregulated |
| | | WBPaper00042034:NO_upregulated_N2 |
| | | WBPaper00042036:gpIs1(longevity)_regulated |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044316:CH3HgCl_2.0uM_upregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_upregulated |
| | | WBPaper00044746:aging_upregulated_Day5 |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045314:S.aureus-induced_hlh-30(tm1978) |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045390:tunicamycin_upregulated |
| | | WBPaper00045401:N.parisii_64h_upregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046741:Garlic-Extract_downregulated_mRNA |
| | | WBPaper00048785:heat-shock_upregulated |
| | | WBPaper00048971:daf-16(mgDf50)_downregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049018:swsn-2.2(RNAi)_downregulated |
| | | WBPaper00049072:caffeine(30mM)_upregulated |
| | | WBPaper00049098:heat-induced_hrde-1(tm1200) |
| | | WBPaper00049495:starvation-refeeding_regulated |
| | | WBPaper00049635:dop-1(vs100)_upregulated |
| | | WBPaper00049736:15deg-then-25deg(12hr)_upregulated_N2 |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051021:4-bromodiphenyl-ether_upregulated |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00053092:procyanidins_upregulated |
| | | WBPaper00053140:DecreasingResponse_20nmAgCit |
| | | WBPaper00053254:hsp-90(RNAi)_upregulated_protein |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_downregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055386:eat-2(ad465)_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055827:pfd-6(gk493446)_upregulated |
| | | WBPaper00055897:heat-shock_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056167:Cry5B_downregulated |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:flcn-1(ok975)_upregulated |
| | | WBPaper00056617:adr-1(gv6)_downregulated_L4_protein |
| | | WBPaper00056617:adr-2(gv42)_downregulated_L4_protein |
| | | WBPaper00056617:adr-2(ok735)_downregulated_L4_protein |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:Cadmium_upregulated |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058955:heatshock_upregulated_CE |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059334:sacy-1(depletion)_regulated |
| | | WBPaper00059490:dcr-1(m9375)_downregulated |
| | | WBPaper00059598:HeatShock_upregulated |
| | | WBPaper00059605:simr-1(cmp36)_downregulated |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060399:CoCl2_6hr_upregulated_N2 |
| | | WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr |
| | | WBPaper00060434:pH4.33_vs_pH6.33_downrgulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:hsp-16.2-F44E5.4_19238 |
| | | WBPaper00061530:nhr-49(e2144)_upregulated |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00062193:daf-16(RNAi)_downregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062237:dnj-21(RNAi)_upregulated_protein |
| | | WBPaper00062293:clk-1(qm30)_upregulated |
| | | WBPaper00062293:isp-1(qm150)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_upregulated_N2 |
| | | WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13) |
| | | WBPaper00062345:bortezomib_30min_upregulated_zip-1(jy13) |
| | | WBPaper00062456:doxycycline_upregulated_CB4856_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064130:Beta-Amyloid_8h_upregulated_mRNA |
| | | WBPaper00064130:Beta-Amyloid_upregulated_protein |
| | | WBPaper00064163:ZNFX-1_interacting_embryo |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064225:heat-shock_upregulated_protein |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00064789:Day12_vs_Day1_upregulated_neuron |
| | | WBPaper00064850:glh-1(sam65)_upregulated |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00064952:Day1_vs_L4_downregulated_20C |
| | | WBPaper00064952:Day10_vs_Day1_upregulated_20C |
| | | WBPaper00064952:Day10_vs_Day1_upregulated_25C |
| | | WBPaper00064992:Eugenol_downregulated |
| | | WBPaper00064992:heat-shock_upregulated |
| | | WBPaper00065005:sams-3(RNAi)_upregulated |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected |
| | | WBPaper00065225:nhr-42(tm1375)_downregulated_uninfected |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065746:tmc-1(rg1003)_downregulated |
| | | WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_upregulated_N2 |
| | | WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein |
| | | WBPaper00066038:mip-1(how5)_downregulated |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_WT |
| | | cgc4386_cluster_3_5 |
| | | cgc4489_group_8 |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_downregulated |
| | | WBPaper00024671:AFD_vs_AWB_upregulated |
| | | WBPaper00025099:NI_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027342:alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00027342:alpha-Synuclein(WT)_upregulated |
| | | WBPaper00027758:Group_III |
| | | WBPaper00028474:dys-1_downregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034661:AgNPs_upregulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00034757:up_by_oxidative_stress |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035479:daf-16(RNAi)_downregulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036383:ash-2_L3_regulated |
| | | WBPaper00036429:glp-1(oz112)_upregulated |
| | | WBPaper00037695:LD_3-day |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00038231:Cry5B_2-fold_upregulated |
| | | WBPaper00039792:TempShiftDecrease |
| | | WBPaper00039866:ClassComp_daf-19_upregulated |
| | | WBPaper00039866:SAM_daf-19_upregulated |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotype_environment_interaction |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041211:RPW-24_Up |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041960:daf-16_fasting_upregulated |
| | | WBPaper00041960:jun-1_fasting_upregulated |
| | | WBPaper00041960:kgb-1_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated_9hto12h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00042128:gei-8(ok1671)_upregulated |
| | | WBPaper00042574:rde-1(ne219)_OrsayVirus_upregulated |
| | | WBPaper00043980:arsenic_upregulated |
| | | WBPaper00044091:Bpseudomallei_induced_4h |
| | | WBPaper00044091:Bpseudomallei_induced_8h |
| | | WBPaper00044091:Bpseudomallei_induced_12h |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00045437:Toxic-Se_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00046639:tyrosol_upregulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00049311:AgNO3_regulated |
| | | WBPaper00050407:hsp-6(RNAi)_upregulated |
| | | WBPaper00050538:Fasting_upregulated |
| | | WBPaper00050767:Octopamine_induced |
| | | WBPaper00051387:Triclosan_downregulated |
| | | WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated |
| | | WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | | [cgc5767]:cluster_52 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(53_min) |
| | | [cgc5976]:class_1 |
| | Interaction (92) |
| | WBProcess | WBbiopr:00000050 |
| Map_info (4) |
| Reference (121) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
