| WBGene00001679 | SMap | S_parent | Sequence | CHROMOSOME_II |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | gpb-1 | Person_evidence | WBPerson625 |
| | | Sequence_name | F13D12.7 |
| | | Molecular_name | F13D12.7a |
| | | | F13D12.7a.1 |
| | | | CE02186 |
| | | | F13D12.7b |
| | | | CE44352 |
| | | | F13D12.7b.1 |
| | | | F13D12.7b.2 |
| | | | F13D12.7b.3 |
| | | | F13D12.7b.4 |
| | | | F13D12.7b.5 |
| | | Other_name | CELE_F13D12.7 | Accession_evidence | NDB | BX284602 |
| | | Public_name | gpb-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 02 Mar 2018 10:40:21 | WBPerson4025 | Event | Split_into | WBGene00303054 |
| | | Split_into | WBGene00303054 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | gpb |
| | Allele (125) |
| | Legacy_information | [C.elegansII] pk13. Tc1 insertion, also excision derivatives pk44: recessive lethal, arrests at L1 stage with very little body wall or pharyngeal muscle activity. In absence of maternal rescue, probably arrests as early embryonic lethal. [NL; JA] |
| | Strain | WBStrain00028901 |
| | | WBStrain00028903 |
| | | WBStrain00036648 |
| | RNASeq_FPKM (74) |
| | GO_annotation (13) |
| | Ortholog (52) |
| | Paralog | WBGene00001680 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | gpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline. | Paper_evidence | WBPaper00002525 |
| | | | | | WBPaper00004576 |
| | | | | | WBPaper00005878 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable signaling receptor complex adaptor activity. Involved in several processes, including establishment of mitotic spindle orientation; negative regulation of locomotion; and regulation of egg-laying behavior. Predicted to be located in cytoplasm. Predicted to be part of heterotrimeric G-protein complex. Expressed in several structures, including body wall musculature; germ line; intestine; pharynx; and vulval cell. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease dominant intermediate F; artery disease (multiple); and hematologic cancer (multiple). Is an ortholog of human GNB1 (G protein subunit beta 1) and GNB4 (G protein subunit beta 4). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (13) |
| Molecular_info | Corresponding_CDS | F13D12.7a |
| | | F13D12.7b |
| | Corresponding_CDS_history | F13D12.7c:wp264 |
| | Corresponding_transcript | F13D12.7a.1 |
| | | F13D12.7b.1 |
| | | F13D12.7b.2 |
| | | F13D12.7b.3 |
| | | F13D12.7b.4 |
| | | F13D12.7b.5 |
| | Other_sequence (133) |
| | Associated_feature (38) |
| Experimental_info | RNAi_result (25) |
| | Expr_pattern | Expr2747 |
| | | Expr1028276 |
| | | Expr1031000 |
| | | Expr1148454 |
| | | Expr2012199 |
| | | Expr2030435 |
| | Drives_construct | WBCnstr00001682 |
| | | WBCnstr00036777 |
| | Construct_product | WBCnstr00001677 |
| | | WBCnstr00001682 |
| | | WBCnstr00016189 |
| | | WBCnstr00021505 |
| | | WBCnstr00036777 |
| | Antibody | WBAntibody00000117 |
| | | WBAntibody00001067 |
| | | WBAntibody00002914 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00032425:up_in_zfp-1 |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033208:STI-1_interacting |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00038118:stress_upregulated_N2 |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00041072:UTX-1_interacting_protein |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044034:LEC-1_associated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052987:UV_upregulated_xpc-1;csb-1 |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053810:sod-2(ok1030)_upregulated |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_protein |
| | | WBPaper00058691:CFP-1_interacting_protein |
| | | WBPaper00058725:sftb-1(cer39)_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059174:PGL-1_interacting |
| | | WBPaper00059194:KLF-1_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:MYRF-2_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:gpb-1_3783-C48A7.2_22459 |
| | | WBPaper00061527:hlh-30_18579-unc-43_21739 |
| | | WBPaper00061651:AVG_enriched |
| | | WBPaper00061651:AWC_OFF_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064494:postdauer_upregulated_AWA |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | cgc4386_cluster_6_5 |
| | | cgc4489_group_20 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00037611:GLD-2-associated |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041906:I-4317_vs_OP50_10d |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | Interaction (165) |
| | WBProcess | WBbiopr:00000120 |
| Map_info | Map | II | Position | 4.02815 | Error | 0.004498 |
| | Well_ordered |
| | Positive | Positive_clone | F13D12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | RP#BL3 |
| | Mapping_data | Multi_point | 4224 |
| | | | 4453 |
| Reference (75) |
| Method | Gene |
