WormBase Tree Display for Gene: WBGene00001680
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| WBGene00001680 | SMap | S_parent | Sequence | F52A8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gpb-2 | Person_evidence | WBPerson625 | |||||
| Sequence_name | F52A8.2 | ||||||||
| Molecular_name | F52A8.2a | ||||||||
| F52A8.2a.1 | |||||||||
| CE50400 | |||||||||
| F52A8.2b | |||||||||
| Other_name | eat-11 | ||||||||
| gbp-2 | Paper_evidence | WBPaper00033094 | |||||||
| CELE_F52A8.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | gpb-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 15 Dec 2010 15:28:40 | WBPerson2970 | Event | Acquires_merge | WBGene00001524 | ||||
| Name_change | Other_name | gbp-2 | |||||||
| Acquires_merge | WBGene00001524 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gpb | ||||||||
| Allele (47) | |||||||||
| Legacy_information | [Leon Avery] Weak Eat: slippery corpus. Slightly long. Movement slightly loopy (i.e. bends are deeper than normal). Hypersensitive to arecoline: will not grown at concentrations >= 1 mM. | ||||||||
| See also ad541 | |||||||||
| [C.elegansII] ad541 : weak Eat: slippery corpus. Slightly long. Movement slightly loopy (i.e. bends are deeper than normal). Hypersensitive to arecoline (cholinergic agonist): will not grown at concentrations >= 1 mM. Synthetic lethal with eat-6; suppressed by egl-30(gf), exp-2(gf). NA1. [Avery 1993; DA; JT] | |||||||||
| [M Robatzek] eat-11 is allelic to gpb-2 (Robatzek et al. Current Biology 2001, 11:288-293) | |||||||||
| Strain | WBStrain00028988 | ||||||||
| WBStrain00029004 | |||||||||
| WBStrain00022804 | |||||||||
| WBStrain00028986 | |||||||||
| WBStrain00037676 | |||||||||
| WBStrain00005480 | |||||||||
| WBStrain00005517 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00001679 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | gpb-2 encodes an ortholog of Gbeta(5), that is dispensable for viability, but required for normal egg-laying, locomotion, and pharyngeal pumping; GBP-2 may regulate the interaction between the GOA-1 and EGL-30 signaling pathways based on genetic analysis; gpb-2 is expressed throughout development in the nervous system and in muscle, and expression is dependent upon expression of both EAT-16 and EGL-10. | Paper_evidence | WBPaper00002466 | |||||
| WBPaper00004406 | |||||||||
| WBPaper00004687 | |||||||||
| WBPaper00004713 | |||||||||
| WBPaper00004714 | |||||||||
| WBPaper00014715 | |||||||||
| WBPaper00015075 | |||||||||
| WBPaper00015719 | |||||||||
| WBPaper00016788 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable signaling receptor complex adaptor activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of egg-laying behavior; and regulation of pharyngeal pumping. Located in neuronal cell body. Expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in intellectual developmental disorder with cardiac arrhythmia. Is an ortholog of human GNB5 (G protein subunit beta 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0081008 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4401) | ||||
| Molecular_info | Corresponding_CDS | F52A8.2a | |||||||
| Corresponding_CDS_history | F52A8.2:wp246 | ||||||||
| Corresponding_transcript | F52A8.2b | ||||||||
| F52A8.2a.1 | |||||||||
| Other_sequence (82) | |||||||||
| Associated_feature | WBsf984145 | ||||||||
| WBsf984146 | |||||||||
| WBsf1010061 | |||||||||
| WBsf1010062 | |||||||||
| WBsf219742 | |||||||||
| WBsf219743 | |||||||||
| WBsf219744 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00047906 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00089830 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032572 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116830 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063514 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090194 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089876 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090035 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1344 | ||||||||
| Expr1360 | |||||||||
| Expr1020669 | |||||||||
| Expr1031001 | |||||||||
| Expr1151735 | |||||||||
| Expr2012200 | |||||||||
| Expr2030436 | |||||||||
| Drives_construct | WBCnstr00000572 | ||||||||
| WBCnstr00001696 | |||||||||
| WBCnstr00001704 | |||||||||
| WBCnstr00022812 | |||||||||
| WBCnstr00036776 | |||||||||
| Construct_product | WBCnstr00001696 | ||||||||
| WBCnstr00036776 | |||||||||
| Antibody | WBAntibody00000370 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (64) | |||||||||
| Map_info | Map | I | Position | 1.91015 | Error | 0.005018 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F52A8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| R02H7 | |||||||||
| Negative | Negative_clone | F07A5 | |||||||
| Mapping_data | 2_point | 6193 | |||||||
| Multi_point | 2456 | ||||||||
| 2457 | |||||||||
| 2458 | |||||||||
| 2459 | |||||||||
| 2460 | |||||||||
| 3034 | |||||||||
| 3946 | |||||||||
| 3947 | |||||||||
| 4489 | |||||||||
| 4710 | |||||||||
| Pos_neg_data | 7086 | ||||||||
| 7087 | |||||||||
| 7088 | |||||||||
| Reference (70) | |||||||||
| Remark | Interacting_genes '[Leon Avery] eat-6: Lethal or subviable in double mutants with eat-6. | ||||||||
| Interacting_genes '[Leon Avery] egl-30: Suppressed by egl-30(gf) mutations. | |||||||||
| Method | Gene |
