| WBGene00001401 | SMap | S_parent | Sequence | H12I13 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | fbf-1 | Person_evidence | WBPerson320 |
| | | Sequence_name | H12I13.4 |
| | | Molecular_name | H12I13.4 |
| | | | H12I13.4.1 |
| | | | CE20960 |
| | | Other_name | FBF | Paper_evidence | WBPaper00053101 |
| | | | | | WBPaper00053705 |
| | | | CELE_H12I13.4 | Accession_evidence | NDB | BX284602 |
| | | Public_name | fbf-1 |
| | DB_info | Database | AceView | gene | 2G370 |
| | | | WormQTL | gene | WBGene00001401 |
| | | | WormFlux | gene | WBGene00001401 |
| | | | NDB | locus_tag | CELE_H12I13.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001401|UniProtKB=Q9N5M6 |
| | | | | family | PTHR12537 |
| | | | NCBI | gene | 174016 |
| | | | RefSeq | protein | NM_062815.8 |
| | | | SwissProt | UniProtAcc | Q9N5M6 |
| | | | TREEFAM | TREEFAM_ID | TF318622 |
| | | | UniProt_GCRP | UniProtAcc | Q9N5M6 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | fbf |
| | Allele (53) |
| | Legacy_information | [Gallegos M, Zhang B] fbf-1(RNAi) animals produce excess sperm and no oocytes (Mog phenotype). Encodes fem-3 PME RNA binding protein, 91% identical to FBF-2 |
| | Strain | WBStrain00022602 |
| | | WBStrain00022603 |
| | | WBStrain00022612 |
| | | WBStrain00022628 |
| | | WBStrain00022640 |
| | | WBStrain00022344 |
| | | WBStrain00022346 |
| | | WBStrain00022396 |
| | | WBStrain00022400 |
| | RNASeq_FPKM (74) |
| | GO_annotation (27) |
| | Ortholog (33) |
| | Paralog | WBGene00004239 | Caenorhabditis elegans | From_analysis | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001402 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00022257 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004241 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004243 | Caenorhabditis elegans | From_analysis | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004242 | Caenorhabditis elegans | From_analysis | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004240 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | WBGene00004244 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004245 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | fbf-1 encodes an RNA-binding protein that is one of 12 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-1 is nearly identical to FBF-2 with which it is largely redundant in regulating two aspects of germline development: 1) maintenance of stem cell proliferation, and 2) the hermaphroditic switch between spermatogenesis and oogenesis; FBF-1 also plays a role in regulating adaptation in the AWC chemosensory neuron by binding and enhancing translation of the egl-4 mRNA; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. | Paper_evidence | WBPaper00002949 |
| | | | | | WBPaper00004396 |
| | | | | | WBPaper00005265 |
| | | | | | WBPaper00005566 |
| | | | | | WBPaper00006369 |
| | | | | | WBPaper00032496 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Feb 2009 00:00:00 |
| | | Automated_description | Enables mRNA 3'-UTR binding activity. Involved in several processes, including germline cell cycle switching, mitotic to meiotic cell cycle; olfactory learning; and regulation of gene expression. Located in germ cell nucleus and perinuclear region of cytoplasm. Expressed in germ line. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | H12I13.4 |
| | Corresponding_transcript | H12I13.4.1 |
| | Associated_feature | WBsf650110 |
| | | WBsf1012315 |
| | | WBsf223128 |
| | Gene_product_binds | WBsf027922 |
| | | WBsf034330 |
| | Transcription_factor | WBTranscriptionFactor000123 |
| | | WBTranscriptionFactor000103 |
| Experimental_info | RNAi_result (58) |
| | Expr_pattern | Expr1450 |
| | | Expr1452 |
| | | Expr1892 |
| | | Expr3517 |
| | | Expr3519 |
| | | Expr3796 |
| | | Expr13083 |
| | | Expr14531 |
| | | Expr14596 |
| | | Expr15895 |
| | | Expr1030839 |
| | | Expr1153116 |
| | | Expr2011443 |
| | | Expr2029681 |
| | Drives_construct | WBCnstr00005287 |
| | | WBCnstr00036969 |
| | Construct_product | WBCnstr00000086 |
| | | WBCnstr00005234 |
| | | WBCnstr00036969 |
| | | WBCnstr00040358 |
| | | WBCnstr00042579 |
| | Regulate_expr_cluster | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00045618:fbf-1_downregulated |
| | | WBPaper00045618:fbf-1_upregulated |
| | | WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched |
| | | WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched |
| | Antibody | WBAntibody00000156 |
| | | WBAntibody00000784 |
| | | WBAntibody00000964 |
| | | WBAntibody00001086 |
| | | WBAntibody00002142 |
| | | WBAntibody00002385 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045618:fbf-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h |
| | | WBPaper00048611:MnCl2_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_8 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049954:BPS_downregulated |
| | | WBPaper00050080:rbr-2(tm3141)_downregulated |
| | | WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo |
| | | WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1 |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051310:LIN-41_interacting |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053295:lin-22(icb38)_downregulated |
| | | WBPaper00053321:lin-15B(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056165:mina-1(ok1521)_upregulated_transcript |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057006:DietaryRestriction_downregulated |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058725:sftb-1(cer39)_downregulated |
| | | WBPaper00059566:wdr-23(mac32)_downregulated |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061203:let-418(n3536)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:Germline |
| | | WBPaper00061340:Neuroblast_HSN_PHB |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:pgl-1-wago-2 |
| | | WBPaper00062056:lin-37(n758)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062497:xpf-1(tm2842)_downregulated |
| | | WBPaper00062587:lsl-1(ljm1)_downregulated |
| | | WBPaper00062587:lsl-1(tm4769)_downregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065749:Heat-Shock_upregulated_N2 |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065984:pals-17(syb3980)_upregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | cgc4489_group_2 |
| | | WBPaper00025032:cluster_4 |
| | | WBPaper00026629:L4_hermaphrodite_enriched |
| | | WBPaper00032165:A_to_C_transit_decreased |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_5 |
| | | WBPaper00032948:FedUp |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00036429:glp-1(oz112)_upregulated |
| | | WBPaper00038060:SUMO-1_upregulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_0.2mM_Down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-4317_vs_OP50_10d |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00046548:dafachronic-acid_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(66_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | Interaction (89) |
| Map_info | Map | II | Position | -0.571982 | Error | 0.010563 |
| | Positive | Positive_clone | H12I13 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | Y56A9 |
| | Mapping_data | Multi_point | 4304 |
| | | | 4305 |
| | | | 5274 |
| | Pseudo_map_position |
| Reference (142) |
| Picture | WBPicture0000013095 |
| Remark | Data extracted from Zhang et al. (1997) |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
