WormBase Tree Display for Gene: WBGene00001169

WBGene00001169 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: eef-1A.2 Person_evidence: WBPerson1787
            WBPerson10190
      Sequence_name: R03G5.1
      Molecular_name: R03G5.1
        R03G5.1.1
        CE01270
        R03G5.1.2
        R03G5.1.3
      Other_name: eln-2
        eft-4
        C54D2.a Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        R03G5.a Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        R03G5.b Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_R03G5.1 Accession_evidence: NDB BX284606
      Public_name: eef-1A.2
    DB_info: Database: AceView gene XI443
        WormQTL gene WBGene00001169
        WormFlux gene WBGene00001169
        NDB locus_tag CELE_R03G5.1
        NCBI gene 181044
        RefSeq protein NM_076922.5
        SwissProt UniProtAcc P53013
        UniProt_GCRP UniProtAcc P53013
        OMIM gene 602959
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 03 Aug 2010 09:32:43 WBPerson2970 Name_change: CGC_name: eef-1A-2
                Other_name: eft-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: eef
    Allele (48)
    Legacy_information: [C.elegansII] NMK. Encodes EF1 alpha protein, aa sequence identical to eft-3. [FK]
    RNASeq_FPKM (74)
    GO_annotation: 00108369
      00108370
      00108371
      00108372
    Ortholog (50)
    Paralog (17)
    Structured_description: Concise_description: eef-1A.2 encodes a translation elongation factor 1-alpha homolog that is required for embryonic viability, fertility, and a normal postembryonic growth rate; eef-1A.2 encodes at least one alternatively spliced coding sequence identical to that of eef-1A.1. Paper_evidence: WBPaper00004313
            WBPaper00004540
            WBPaper00005654
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson567
          Date_last_updated: 03 Dec 2014 00:00:00
      Automated_description: Predicted to enable GTP binding activity; GTPase activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Is an ortholog of human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1); EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5); and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3192)
      DOID:0070068 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3192)
      DOID:0080463 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3192)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3192)
  Molecular_info: Corresponding_CDS: R03G5.1
    Corresponding_CDS_history: R03G5.1b:wp272
      R03G5.1c:wp272
      R03G5.1d:wp162
      R03G5.1d:wp272
    Corresponding_transcript: R03G5.1.1
      R03G5.1.2
      R03G5.1.3
    Other_sequence (769)
    Associated_feature (21)
  Experimental_info: RNAi_result (30)
    Expr_pattern: Expr1030746
      Expr1154893
      Expr2011178
      Expr2029414
    Drives_construct (11)
    Construct_product: WBCnstr00037980
    Microarray_results (34)
    Expression_cluster: WBPaper00024704:Soluble_protein
      WBPaper00030894:daf-2(e1370ts)_downregulated
      WBPaper00030922:glycosylated_protein
      WBPaper00032009:nhr-40(ok667)_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00036662:oxidative_modification
      WBPaper00037109:cyclophilin-inhibitor_regulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038289:oocyte_protein
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00042215:wdr-23(tm1817)_downregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00043951:Nascent-polypeptide-associated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045861:set-2(ok952)_upregulated
      WBPaper00046303:P.aeruginosa_upregulated_protein
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048644:germline_enriched
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049594:osm-9(ok1677)_upregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050514:CEBP-1_interacting
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051538:micro-gavity_upregulated_protein
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055013:HMG-4_interacting_protein
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056826:SGP_biased
      WBPaper00056900:ERH-2_interacting
      WBPaper00056900:PID-3_interacting
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056900:TOST-1_interacting
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_upregulated
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059194:KLF-1_interacting
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00060908:TEBP-1_interacting
      WBPaper00060908:TEBP-2_interacting
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061040:FW1256_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:mc3
      WBPaper00061340:pm7
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4748)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061527:tars-1-AFFX-r2-3026-5_at
      WBPaper00061651:CAN_enriched
      WBPaper00061651:I4_enriched
      WBPaper00061651:MI_enriched
      WBPaper00061651:NSM_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061651:VB_enriched
      WBPaper00062002:L3_secretome
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00063976:micu-1(bon20)_downregulated
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064163:ZNFX-1_interacting_young-adult
      WBPaper00064201:SNA-1_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064735:bet-1(RNAi)_vs_N2_upregulated
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065005:sams-3(RNAi)_downregulated
      WBPaper00065086:N2_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065158:AFD_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_3_4
      cgc4489_group_8
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00025032:cluster_10
      WBPaper00025099:NI_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027111:rde-3(r459)_upregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00032165:A_to_C_transit_increased
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00034739:N2lessDR1350
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040821:Au-NP_regulated
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00045865:biofilm_downregulated_B
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(53_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
    Interaction (307)
  Map_info: Map: X Position: -1.12456
    Positive: Positive_clone: R03G5 Inferred_automatically: From sequence, transcript, pseudogene data
        YO#EFG5
    Pseudo_map_position
  Reference: WBPaper00024924
    WBPaper00025088
    WBPaper00027281
    WBPaper00037777
    WBPaper00038491
    WBPaper00049828
    WBPaper00055090
    WBPaper00065634
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene