Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00000845

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00000845EvidencePerson_evidenceWBPerson170
SMapS_parentSequenceC02C2
IdentityVersion1
NameCGC_namecup-4Person_evidenceWBPerson170
Sequence_nameC02C2.3
Molecular_nameC02C2.3
C02C2.3.1
CE30416
Other_nameCELE_C02C2.3Accession_evidenceNDBBX284603
Public_namecup-4
DB_infoDatabaseAceViewgene3I957
WormQTLgeneWBGene00000845
WormFluxgeneWBGene00000845
NDBlocus_tagCELE_C02C2.3
PanthergeneCAEEL|WormBase=WBGene00000845|UniProtKB=P34271
familyPTHR18945
NCBIgene176104
RefSeqproteinNM_066309.6
SwissProtUniProtAccP34271
UniProt_GCRPUniProtAccP34271
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcup
AlleleWBVar00000260
WBVar02034232
WBVar00841465
WBVar00841466
WBVar00841467
WBVar00841468
WBVar01500260
WBVar02148234
WBVar00841469
WBVar00841470
WBVar00841471
WBVar00841472
WBVar00841473
WBVar00841474
WBVar00269877
WBVar01645561
WBVar01645562
WBVar01645563
WBVar02073258
WBVar01499774
WBVar00099754
WBVar00099755
WBVar00249810
WBVar01446912
WBVar00092115
WBVar01479980
WBVar00402325
WBVar00402326
WBVar00402327
WBVar02003359
WBVar00402328
WBVar00402329
WBVar00402330
WBVar00402331
StrainWBStrain00031661
RNASeq_FPKM (74)
GO_annotation (31)
Ortholog (29)
Paralog (100)
Structured_descriptionConcise_descriptioncup-4 encodes a non-alpha ligand-gated ion channel with similarity to the nicotinic acetylcholine receptors; cup-4 is required cell autonomously for efficient fluid endocytosis in coelomocytes; cup-4 mutant animals display reduced levels of plasma membrane phosphatidylinositol 4,5-bisphosphate, suggesting that CUP-4 may regulate endocytosis via regulation of phospholipase C activity; in addition, cup-4 mutants display disorganized clathrin and RME-1 at the coelomocyte plasma membrane; CUP-4::GFP is expressed in coelomocytes where it localizes to the cytoplasm, primarily to cytoplasmic vesicles.Paper_evidenceWBPaper00004883
WBPaper00006324
WBPaper00025238
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated01 Sep 2010 00:00:00
Automated_descriptionPredicted to enable neurotransmitter receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and response to caloric restriction. Located in cytoplasmic vesicle membrane.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC02C2.3
Corresponding_transcriptC02C2.3.1
Other_sequenceJO468316.1
JI169898.1
Oden_isotig23439
Associated_featureWBsf645364
WBsf225290
Experimental_infoRNAi_result (14)
Expr_patternExpr3280
Expr16469
Expr1011461
Expr1030524
Expr1143520
Expr1200314
Expr2010596
Expr2028836
Drives_constructWBCnstr00005671
WBCnstr00005672
WBCnstr00011282
WBCnstr00037250
Construct_productWBCnstr00007433
WBCnstr00011282
WBCnstr00037250
Microarray_results (20)
Expression_clusterWBPaper00024505:pharyngeal_enriched
WBPaper00033065:clk-1(qm30)_upregulated
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:coelomocytes_CoreEnriched
WBPaper00037950:coelomocytes_embryo_enriched
WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:coelomocytes_larva_enriched
WBPaper00037950:coelomocytes_larva_SelectivelyEnriched
WBPaper00044426:rotenone_5day_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00046121:mesoderm_unique
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00050015:ifg-1(RNAi)_downregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050163:let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056290:mdt-15(mg584)_upregulated
WBPaper00056826:hmc_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058678:DAF-12_upregulated_PVD
WBPaper00059027:neuron-synapses_depleted
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(overexpression)_upregulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00060909:atfs-1(et18)_downregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:Coelomocyte
WBPaper00061340:hmc_and_homolog
WBPaper00061341:28C_24h_upregulated
WBPaper00061527:cup-4_19385-ZC116.3_20579
WBPaper00061651:Coelomocyte_enriched
WBPaper00061692:acivicin_upregulated
WBPaper00061823:mex-3(spr9)_downregulated
WBPaper00062095:unc-4(e120)_upregulated_VA-neuron
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062590:Aging_downregulated_neuron
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065623:31
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:3_0
WBPaper00065841:12_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
cgc4386_cluster_6_6
cgc4489_group_4
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00030985:Photorhabdus_luminescens_downregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00032062:age_regulated_genes
WBPaper00034757:up_by_oxidative_stress
WBPaper00036286:Pattern_I
WBPaper00038462:aging_downregulated
WBPaper00041002:HQ_3d_2.0mM_Down
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00045960:L4-lethargus_downregulated
WBPaper00048989:N2_rapamycin_upregulated
InteractionWBInteraction000051699
WBInteraction000390325
WBInteraction000421321
WBInteraction000585701
Map_infoMapIIIPosition-0.533135Error0.003482
PositivePositive_cloneC02C2Inferred_automaticallyFrom sequence, transcript, pseudogene data
pJF148Person_evidenceWBPerson170
Mapping_dataMulti_point3952
5055
Reference (13)
RemarkpJF148 is identified as positive via stable transformation rescue, ar494 mutation, RNAiPerson_evidenceWBPerson170
MethodGene