| WBGene00000832 | SMap | S_parent | Sequence | Y23H5A |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | ctn-1 | Person_evidence | WBPerson481 |
| | | Sequence_name | Y23H5A.5 |
| | | Molecular_name (12) |
| | | Other_name | Y23H5A.c | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | CELE_Y23H5A.5 | Accession_evidence | NDB | BX284601 |
| | | Public_name | ctn-1 |
| | DB_info | Database | AceView | gene | 1D185 |
| | | | WormQTL | gene | WBGene00000832 |
| | | | WormFlux | gene | WBGene00000832 |
| | | | OMIM | disease | 310200 |
| | | | NDB | locus_tag | CELE_Y23H5A.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000832|UniProtKB=H2L011 |
| | | | | family | PTHR46342 |
| | | | NCBI | gene | 171818 |
| | | | RefSeq | protein | NM_001377804.1 |
| | | | | | NM_170830.6 |
| | | | | | NR_131363.1 |
| | | | | | NM_001393087.1 |
| | | | TREEFAM | TREEFAM_ID | TF313686 |
| | | | TrEMBL | UniProtAcc | Q8T3U1 |
| | | | | | G8JYB2 |
| | | | | | H2L011 |
| | | | UniProt_GCRP | UniProtAcc | H2L011 |
| | | | RNAcentral | URSid | URS000076D7F0 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ctn |
| | Allele (245) |
| | Strain | WBStrain00037343 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00021143 |
| | | 00021144 |
| | | 00021145 |
| | | 00021146 |
| | | 00021147 |
| | | 00021148 |
| | | 00107861 |
| | | 00107862 |
| | | 00107863 |
| | | 00107864 |
| | Ortholog (35) |
| | Paralog | WBGene00000942 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | | WBGene00001978 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | ctn-1 encodes a protein that belongs to the alpha-catulin family of catenin-like proteins; CTN-1 physically interacts in vivo with DYB-1/dystrobrevin; a ctn-1::GFP fusion is expressed in body wall, vulval, and anal muscles; in body wall muscles, CTN-1::GFP localizes to the plasma membranes near dense bodies. | Paper_evidence | WBPaper00011358 |
| | | | | | WBPaper00041089 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 02 Aug 2012 00:00:00 |
| | | Automated_description | Predicted to enable actin filament binding activity and cadherin binding activity. Involved in regulation of locomotion. Located in plasma membrane and striated muscle dense body. Expressed in body wall musculature; non-striated muscle; and somatic nervous system. Used to study Duchenne muscular dystrophy. Is an ortholog of human CTNNAL1 (catenin alpha like 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:11723 | Homo sapiens | Paper_evidence | WBPaper00037625 |
| | | | | Accession_evidence | OMIM | 310200 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 22 May 2017 00:00:00 |
| | Disease_relevance | Mutations in human dystrophin are associated with the Duchenne and Becker types of muscular dystrophy, that affect skeletal muscles used for movement, and heart (cardiac) muscle; a number of transmembrane and peripheral membrane proteins interact with dystrophin to form the dystrophin-associated protein complex (DAPC); defects in components of the DAPC are associated with a variety of pathological conditions, including muscular dystrophy, cardiomyopathy, myoclonic dystonia, and vasospasm; in C. elegans, the DAPC localizes near dense bodies, structures that are analogous to muscle costameres; ctn-1, an ortholog of alpha catulin (catenin-like protein), interacts with dyb-1/dystrobrevin, and this interaction is required for the normal localization of the DAPC as well as for the slo-1 voltage- and calcium-activated potassium (BK) channel, in C. elegans muscle; in the dystrophic mdx mice, there is compensatory increase of alpha-catulin expression in the skeletal muscle where the DAPC is disassembled, and the mechanical link between the muscle costamere and the sarcolemma is lost. | Homo sapiens | Paper_evidence | WBPaper00037625 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 22 May 2017 00:00:00 |
| Models_disease_asserted | WBDOannot00000293 |
| Molecular_info | Corresponding_CDS | Y23H5A.5a |
| | | Y23H5A.5c |
| | | Y23H5A.5d |
| | Corresponding_CDS_history | Y23H5A.5a:wp274 |
| | | Y23H5A.5b:wp274 |
| | | Y23H5A.5c:wp228 |
| | | Y23H5A.5d:wp210 |
| | | Y23H5A.5d:wp228 |
| | Corresponding_transcript | Y23H5A.5e |
| | | Y23H5A.5a.1 |
| | | Y23H5A.5c.1 |
| | | Y23H5A.5d.1 |
| | | Y23H5A.5d.2 |
| | | Y23H5A.5d.3 |
| | Other_sequence (47) |
| | Associated_feature | WBsf982915 |
| | | WBsf982916 |
| | | WBsf1009363 |
| | | WBsf217315 |
| | | WBsf217316 |
| Experimental_info | RNAi_result | WBRNAi00002350 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00055702 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00055701 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00116607 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00004565 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00022472 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00036720 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00008299 |
| | | WBCnstr00008300 |
| | | WBCnstr00013721 |
| | | WBCnstr00013723 |
| | | WBCnstr00018330 |
| | | WBCnstr00037258 |
| | Construct_product | WBCnstr00008299 |
| | | WBCnstr00008300 |
| | | WBCnstr00008301 |
| | | WBCnstr00008302 |
| | | WBCnstr00013723 |
| | | WBCnstr00013724 |
| | | WBCnstr00018330 |
| | | WBCnstr00020433 |
| | | WBCnstr00037258 |
| | Microarray_results (51) |
| | Expression_cluster | WBPaper00032425:up_in_zfp-1 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_larva_enriched |
| | | WBPaper00037950:hypodermis_larva_SelectivelyEnriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:alovudine_72h_regulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055386:eat-2(ad465)_downregulated |
| | | WBPaper00055386:eat-2(ad465)_upregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056218:daf-16(mu86)_upregulated_Day7 |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061527:pkn-1_20439-tbc-12_11015 |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:I3_enriched |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_downregulated_protein |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:20_2 |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:46_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | cgc4386_cluster_6_4 |
| | | cgc4386_cluster_6_5 |
| | | cgc4489_group_19 |
| | | cgc4489_group_21 |
| | | WBPaper00005475:Aging-regulated |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_25 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027342:alpha-Synuclein(A53T)_downregulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00037113:Diazinon_16C_regulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00039851:HK_C_albicans_vs_HK_OP50 |
| | | WBPaper00039851:Live_C_albicans_vs_HK_OP50 |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_downregulated |
| | | WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_A |
| | Interaction (29) |
| Map_info | Map | I | Position | -8.18787 | Error | 0.026165 |
| | Positive | Positive_clone | Y23H5A | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00011358 |
| | WBPaper00036762 |
| | WBPaper00037625 |
| | WBPaper00038491 |
| | WBPaper00039233 |
| | WBPaper00041089 |
| | WBPaper00043421 |
| | WBPaper00046703 |
| | WBPaper00055090 |
| | WBPaper00065040 |
| Remark | Sequence connection from [Broadbent ID], 02/06/12 krb. |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
