WormBase Tree Display for Gene: WBGene00000831
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| WBGene00000831 | SMap | S_parent | Sequence | Y54G11A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ctl-2 | Person_evidence | WBPerson95 | |||||
| Sequence_name | Y54G11A.5 | ||||||||
| Molecular_name | Y54G11A.5 | ||||||||
| Y54G11A.5.1 | |||||||||
| CE22476 | |||||||||
| Other_name | cat1 | Accession_evidence | EMBL | Y14065 | |||||
| CAT | Accession_evidence | EMBL | X82175 | ||||||
| CELE_Y54G11A.5 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | ctl-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ctl | ||||||||
| Allele (61) | |||||||||
| Strain | WBStrain00024103 | ||||||||
| WBStrain00036038 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000830 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00013220 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ctl-2 encodes one of three C. elegans catalases; CTL-2 exhibits catalase and peroxidase activity in vitro, and thus likely functions in vivo as an antioxidant enzyme that protects cells from reactive oxygen species; ctl-2 activity is required for normal lifespan as well as for the extended lifespan seen in daf-2 mutant animals; in addition, ctl-2 is required for normal egg-laying capacity and for normal peroxisomal morphology; immunoelectron microscopy indicates that CTL-2 is found mainly in the peroxisomes of intestinal epithelial cells; ctl-2 expression is negatively regulated by DAF-2-mediated insulin signaling. | Paper_evidence | WBPaper00003973 | |||||
| WBPaper00005976 | |||||||||
| WBPaper00006515 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 22 May 2006 00:00:00 | ||||||||
| Automated_description | Enables catalase activity. Involved in determination of adult lifespan and peroxisome organization. Located in peroxisome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Is an ortholog of human CAT (catalase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (48) | ||||||||
| Molecular_info | Corresponding_CDS | Y54G11A.5 | |||||||
| Corresponding_CDS_history | Y54G11A.5a:wp144 | ||||||||
| Y54G11A.5b:wp144 | |||||||||
| Corresponding_transcript | Y54G11A.5.1 | ||||||||
| Other_sequence | X82175 | ||||||||
| EX553408.1 | |||||||||
| FC541902.1 | |||||||||
| Associated_feature | WBsf019144 | ||||||||
| WBsf224257 | |||||||||
| WBsf224258 | |||||||||
| WBsf224259 | |||||||||
| WBsf224260 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1319 | ||||||||
| Expr1321 | |||||||||
| Expr1021293 | |||||||||
| Expr1030513 | |||||||||
| Expr1160866 | |||||||||
| Expr2010576 | |||||||||
| Expr2028816 | |||||||||
| Drives_construct | WBCnstr00005460 | ||||||||
| WBCnstr00019137 | |||||||||
| WBCnstr00037259 | |||||||||
| Construct_product | WBCnstr00005460 | ||||||||
| WBCnstr00010216 | |||||||||
| WBCnstr00037259 | |||||||||
| WBCnstr00042621 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (203) | |||||||||
| Interaction (119) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| WBbiopr:00000096 | |||||||||
| WBbiopr:00000121 | |||||||||
| Map_info | Map | II | Position | 22.9014 | Error | 0.000566 | |||
| Positive | Positive_clone | Y54G11A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4938 | |||||||
| 4241 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (116) | |||||||||
| Remark | Sequence connection from Eleanor Whitfield [020610 krb] | ||||||||
| Please note that although this gene has also been described as 'cat-1', the official (CGC approved) cat-1 is a completely different gene [030120 ck1] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
