WormBase Tree Display for Gene: WBGene00000831

WBGene00000831 SMap: S_parent: Sequence: Y54G11A
  Identity: Version: 1
    Name: CGC_name: ctl-2 Person_evidence: WBPerson95
      Sequence_name: Y54G11A.5
      Molecular_name: Y54G11A.5
        Y54G11A.5.1
        CE22476
      Other_name: cat1 Accession_evidence: EMBL Y14065
        CAT Accession_evidence: EMBL X82175
        CELE_Y54G11A.5 Accession_evidence: NDB BX284602
      Public_name: ctl-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ctl
    Allele (61)
    Strain: WBStrain00024103
      WBStrain00036038
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (37)
    Paralog: WBGene00000830 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00013220 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: ctl-2 encodes one of three C. elegans catalases; CTL-2 exhibits catalase and peroxidase activity in vitro, and thus likely functions in vivo as an antioxidant enzyme that protects cells from reactive oxygen species; ctl-2 activity is required for normal lifespan as well as for the extended lifespan seen in daf-2 mutant animals; in addition, ctl-2 is required for normal egg-laying capacity and for normal peroxisomal morphology; immunoelectron microscopy indicates that CTL-2 is found mainly in the peroxisomes of intestinal epithelial cells; ctl-2 expression is negatively regulated by DAF-2-mediated insulin signaling. Paper_evidence: WBPaper00003973
            WBPaper00005976
            WBPaper00006515
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 22 May 2006 00:00:00
      Automated_description: Enables catalase activity. Involved in determination of adult lifespan and peroxisome organization. Located in peroxisome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Is an ortholog of human CAT (catalase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (48)
  Molecular_info: Corresponding_CDS: Y54G11A.5
    Corresponding_CDS_history: Y54G11A.5a:wp144
      Y54G11A.5b:wp144
    Corresponding_transcript: Y54G11A.5.1
    Other_sequence: X82175
      EX553408.1
      FC541902.1
    Associated_feature: WBsf019144
      WBsf224257
      WBsf224258
      WBsf224259
      WBsf224260
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr1319
      Expr1321
      Expr1021293
      Expr1030513
      Expr1160866
      Expr2010576
      Expr2028816
    Drives_construct: WBCnstr00005460
      WBCnstr00019137
      WBCnstr00037259
    Construct_product: WBCnstr00005460
      WBCnstr00010216
      WBCnstr00037259
      WBCnstr00042621
    Microarray_results (22)
    Expression_cluster (203)
    Interaction (119)
    WBProcess: WBbiopr:00000039
      WBbiopr:00000096
      WBbiopr:00000121
  Map_info: Map: II Position: 22.9014 Error: 0.000566
    Positive: Positive_clone: Y54G11A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4938
        4241
    Pseudo_map_position
  Reference: WBPaper00003527
    WBPaper00003620
    WBPaper00003872
    WBPaper00003973
    WBPaper00005647
    WBPaper00005690
    WBPaper00005976
    WBPaper00006437
    WBPaper00006452
    WBPaper00006515
    WBPaper00006516
    WBPaper00011154
    WBPaper00011955
    WBPaper00015084
    WBPaper00015894
    WBPaper00016821
    WBPaper00018164
    WBPaper00018237
    WBPaper00019107
    WBPaper00021644
    WBPaper00022922
    WBPaper00022992
    WBPaper00025114
    WBPaper00028282
    WBPaper00028782
    WBPaper00028980
    WBPaper00029355
    WBPaper00029409
    WBPaper00030825
    WBPaper00031039
    WBPaper00031124
    WBPaper00031533
    WBPaper00031981
    WBPaper00033133
    WBPaper00035663
    WBPaper00038491
    WBPaper00038506
    WBPaper00039090
    WBPaper00039791
    WBPaper00040849
    WBPaper00041156
    WBPaper00041377
    WBPaper00041408
    WBPaper00041478
    WBPaper00041581
    WBPaper00042367
    WBPaper00043133
    WBPaper00045770
    WBPaper00046368
    WBPaper00047619
    WBPaper00048403
    WBPaper00049481
    WBPaper00049520
    WBPaper00049557
    WBPaper00049828
    WBPaper00050571
    WBPaper00051041
    WBPaper00051166
    WBPaper00051233
    WBPaper00051440
    WBPaper00053004
    WBPaper00053265
    WBPaper00053613
    WBPaper00053670
    WBPaper00053693
    WBPaper00054418
    WBPaper00054769
    WBPaper00055017
    WBPaper00055090
    WBPaper00055104
    WBPaper00055415
    WBPaper00055430
    WBPaper00055760
    WBPaper00055798
    WBPaper00056240
    WBPaper00057005
    WBPaper00057215
    WBPaper00059149
    WBPaper00059354
    WBPaper00059553
    WBPaper00059800
    WBPaper00059983
    WBPaper00060058
    WBPaper00060133
    WBPaper00060156
    WBPaper00060246
    WBPaper00060452
    WBPaper00060558
    WBPaper00060669
    WBPaper00060698
    WBPaper00060895
    WBPaper00060996
    WBPaper00061547
    WBPaper00061764
    WBPaper00061852
    WBPaper00062011
    WBPaper00062024
    WBPaper00062129
    WBPaper00062215
    WBPaper00062405
    WBPaper00063967
    WBPaper00064255
    WBPaper00064442
    WBPaper00064479
    WBPaper00064552
    WBPaper00064639
    WBPaper00064716
    WBPaper00064983
    WBPaper00065090
    WBPaper00065207
    WBPaper00065316
    WBPaper00065694
    WBPaper00065728
    WBPaper00066295
    WBPaper00066329
    WBPaper00066359
  Remark: Sequence connection from Eleanor Whitfield [020610 krb]
    Please note that although this gene has also been described as 'cat-1', the official (CGC approved) cat-1 is a completely different gene [030120 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene